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Q8DHY6

- SPEA_THEEB

UniProt

Q8DHY6 - SPEA_THEEB

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Protein

Biosynthetic arginine decarboxylase

Gene

speA

Organism
Thermosynechococcus elongatus (strain BP-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the biosynthesis of agmatine from arginine.UniRule annotation

Catalytic activityi

L-arginine = agmatine + CO2.UniRule annotation

Cofactori

Magnesium.UniRule annotation
Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. arginine decarboxylase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. arginine catabolic process Source: InterPro
  2. spermidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Polyamine biosynthesis, Spermidine biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding, Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Biosynthetic arginine decarboxylaseUniRule annotation (EC:4.1.1.19UniRule annotation)
Short name:
ADCUniRule annotation
Gene namesi
Name:speAUniRule annotation
Ordered Locus Names:tll1807
OrganismiThermosynechococcus elongatus (strain BP-1)
Taxonomic identifieri197221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesThermosynechococcus
ProteomesiUP000000440: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 637637Biosynthetic arginine decarboxylasePRO_0000149979Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei107 – 1071N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi197221.tll1807.

Structurei

3D structure databases

ProteinModelPortaliQ8DHY6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni289 – 29911Substrate-bindingUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1166.
HOGENOMiHOG000029191.
KOiK01585.
OMAiIDHYVDG.
OrthoDBiEOG676Z0R.

Family and domain databases

Gene3Di2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPiMF_01417. SpeA.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSiPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01273. speA. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8DHY6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALTVTKTSN WTIEDSEQLY RIQGWGEPYF GINAAGHVTV SPKGDRGGSL
60 70 80 90 100
DLYELVQALQ QRNISLPLLL RFSDILEDRI ERLNACFARA IARYGYQGAY
110 120 130 140 150
KGVFPIKCNQ QRHIIEALVR FGQSHQFGLE AGSKPELLIA LAMLNTPGAL
160 170 180 190 200
LICNGYKDRS YIETAILARR LGHTSIIVLE QPEEVAEVIA VSQALGIEPI
210 220 230 240 250
VGVRAKLSTQ GVGRWGTSAG DRAKFGLTVP EILTAVEQLR AAGMLNALQL
260 270 280 290 300
LHFHIGSQIS AISVIKDAIR EAGQIYGELV RLGANMQYLD VGGGLGVDYD
310 320 330 340 350
GSKTNFHASK NYSMQNYASD VVAGIKDACR QRGIPDPTLI SESGRAIASH
360 370 380 390 400
QSVLIFNVLG VSEVPKITPE PATAEEHLII RNLYDTYQAI DENNYQEAYN
410 420 430 440 450
DALQFKGEAI SLFNFGYLSL PERARAESLF WACCAKILGI ARQQEYVPDD
460 470 480 490 500
LEDLEKIMAS IYYINLSVFQ SVPDSWAIDQ LFPIMPIHRL DEEPTERGIL
510 520 530 540 550
ADLTCDSDGK IDQFIDLRDV KSVLELHPFR PGEPYYLGLF LNGAYQEIMG
560 570 580 590 600
NLHNLFGDTN AVHIRLTPKG YEIEHLVRGD TMQEVLGYVQ YQGDALLEKI
610 620 630
RCRTEAALAE EQITLAEAQH LLENYERSLR SYTYLSS
Length:637
Mass (Da):70,856
Last modified:March 1, 2003 - v1
Checksum:iA924C72CB50F29C5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000039 Genomic DNA. Translation: BAC09359.1.
RefSeqiNP_682597.1. NC_004113.1.
WP_011057644.1. NC_004113.1.

Genome annotation databases

EnsemblBacteriaiBAC09359; BAC09359; BAC09359.
GeneIDi1012401.
KEGGitel:tll1807.
PATRICi23928998. VBITheElo119873_1889.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000039 Genomic DNA. Translation: BAC09359.1 .
RefSeqi NP_682597.1. NC_004113.1.
WP_011057644.1. NC_004113.1.

3D structure databases

ProteinModelPortali Q8DHY6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 197221.tll1807.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC09359 ; BAC09359 ; BAC09359 .
GeneIDi 1012401.
KEGGi tel:tll1807.
PATRICi 23928998. VBITheElo119873_1889.

Phylogenomic databases

eggNOGi COG1166.
HOGENOMi HOG000029191.
KOi K01585.
OMAi IDHYVDG.
OrthoDBi EOG676Z0R.

Family and domain databases

Gene3Di 2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPi MF_01417. SpeA.
InterProi IPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view ]
PIRSFi PIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSi PR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR01273. speA. 1 hit.
PROSITEi PS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BP-1.

Entry informationi

Entry nameiSPEA_THEEB
AccessioniPrimary (citable) accession number: Q8DHY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3