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Protein

Inorganic pyrophosphatase

Gene

ppa

Organism
Thermosynechococcus elongatus (strain BP-1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.

Catalytic activityi

Diphosphate + H2O = 2 phosphate.

Cofactori

Mg2+

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei30Substrate1
Binding sitei44Substrate1
Binding sitei56Substrate1
Metal bindingi66Magnesium 11
Metal bindingi71Magnesium 11
Metal bindingi71Magnesium 21
Metal bindingi103Magnesium 11
Binding sitei140Substrate1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Inorganic pyrophosphatase (EC:3.6.1.1)
Alternative name(s):
Pyrophosphate phospho-hydrolase
Short name:
PPase
Gene namesi
Name:ppa
Ordered Locus Names:tll1883
OrganismiThermosynechococcus elongatus (strain BP-1)
Taxonomic identifieri197221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesSynechococcaceaeThermosynechococcus
Proteomesi
  • UP000000440 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001375331 – 172Inorganic pyrophosphataseAdd BLAST172

Interactioni

Subunit structurei

Homohexamer.

Protein-protein interaction databases

STRINGi197221.tll1883.

Structurei

3D structure databases

ProteinModelPortaliQ8DHR2.
SMRiQ8DHR2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPase family.

Phylogenomic databases

eggNOGiENOG4105F0N. Bacteria.
COG0221. LUCA.
HOGENOMiHOG000236472.
KOiK01507.
OMAiDEPTFPG.
OrthoDBiPOG091H05Q5.

Family and domain databases

CDDicd00412. pyrophosphatase. 1 hit.
Gene3Di3.90.80.10. 1 hit.
HAMAPiMF_00209. Inorganic_PPase. 1 hit.
InterProiView protein in InterPro
IPR008162. Pyrophosphatase.
IPR036649. Pyrophosphatase_sf.
PANTHERiPTHR10286. PTHR10286. 1 hit.
PfamiView protein in Pfam
PF00719. Pyrophosphatase. 1 hit.
SUPFAMiSSF50324. SSF50324. 1 hit.
PROSITEiView protein in PROSITE
PS00387. PPASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8DHR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIDLSRIPA QPKPGVVNVL VEIAGGSRNK YEFDKEMKVF ALDRVLYSAV
60 70 80 90 100
VYPYDYGFIP NTLADDGDPL DGLVMMDEPT FPGCVIPARP IGMLEMIDSG
110 120 130 140 150
DRDEKILCVP VDDPRYAEVK SLKDIAPHRL EEIAEFFRTY KNLQKKVTEI
160 170
LGWQDVDAVQ PLVEKCIKAY KG
Length:172
Mass (Da):19,340
Last modified:April 11, 2003 - v2
Checksum:iBE2577FB1E6AB50E
GO

Sequence cautioni

The sequence BAC09435 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000039 Genomic DNA. Translation: BAC09435.1. Different initiation.
RefSeqiNP_682673.1. NC_004113.1.

Genome annotation databases

EnsemblBacteriaiBAC09435; BAC09435; BAC09435.
GeneIDi1010820.
KEGGitel:tll1883.
PATRICifig|197221.4.peg.1967.

Similar proteinsi

Entry informationi

Entry nameiIPYR_THEEB
AccessioniPrimary (citable) accession number: Q8DHR2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: April 11, 2003
Last modified: November 22, 2017
This is version 92 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families