Q8DHH2 (DAPB_THEEB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dihydrodipicolinate reductase
Short name=DHPR
EC=1.3.1.26

Gene names

Name:	dapB
Ordered Locus Names:	tll1987

Organism

Thermosynechococcus elongatus (strain BP-1)

Taxonomic identifier

197221 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Thermosynechococcus

Protein attributes

Sequence length	276 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-2,3,4,5-tetrahydrodipicolinate + NAD(P)+ = (S)-2,3-dihydrodipicolinate + NAD(P)H. HAMAP MF_00102
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4. HAMAP MF_00102
Subcellular location	Cytoplasm By similarity HAMAP MF_00102.
Sequence similarities	Belongs to the dihydrodipicolinate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NADPH binding Inferred from electronic annotation. Source: InterPro dihydrodipicolinate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 276	276	Dihydrodipicolinate reductase HAMAP MF_00102		PRO_0000141499

Sequences

	Sequence		Length	Mass (Da)
	Q8DHH2 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: EA959F31F42624E8	FASTA	276	29,899
	10 20 30 40 50 60 MSELCMSTPI SVIVVGALGK MGREVVKAVH QAPDTALYAA VDRKQVGEDI GEALGLGTLE 70 80 90 100 110 120 IPISGSLQEV CVAAAQEKQP VVMVDFTHPQ AVYENVRMAI AYGVYPVVGT TGLSPEQIEE 130 140 150 160 170 180 LAEFADKADM GAVIAPNFSI GMVLLQEAAI RASQYFDHVE IIELHHNQKA DAPSGTALQT 190 200 210 220 230 240 AQRLAELGKT FNPPQVQESE HLRGARGAFA AAEIRIHSVR LPGLIAHQEV IFGAPGQIYT 250 260 270 LRHDTSDRQC YMPGVLLAIR KVRQLKRLIY GLEKLL

References

[1]

"Complete genome structure of the thermophilic cyanobacterium Thermosynechococcus elongatus BP-1." Nakamura Y., Kaneko T., Sato S., Ikeuchi M., Katoh H., Sasamoto S., Watanabe A., Iriguchi M., Kawashima K., Kimura T., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Nakazaki N., Shimpo S., Sugimoto M. , Takeuchi C., Yamada M., Tabata S. DNA Res. 9:123-130(2002) [PubMed: 12240834] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: BP-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000039 Genomic DNA. Translation: BAC09539.1.
RefSeq	NP_682777.1. NC_004113.1.
3D structure databases
ProteinModelPortal	Q8DHH2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8DHH2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1012443.
GenomeReviews	Gene locus tll1987 in contig BA000039_GR.
KEGG	tel:tll1987.
NMPDR	fig|197221.1.peg.1986.
PATRIC	23929380. VBITheElo119873_2077.
Phylogenomic databases
eggNOG	COG0289.
HOGENOM	HBG594002.
OMA	DRASFMP.
ProtClustDB	PRK00048.
Enzyme and pathway databases
BioCyc	TELO197221:TLL1987-MONOMER.
Family and domain databases
HAMAP	MF_00102. DapB. [Tree]
InterPro	IPR022663. DapB_C. IPR000846. DapB_N. IPR022664. DapB_N_CS. IPR011770. Dihydrodipicolinate_Rdtase. IPR023940. Dihydrodipicolinate_Rdtase_bac. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00215.
PANTHER	PTHR20836. DapB_bac/pln. 1 hit.
Pfam	PF05173. DapB_C. 1 hit. PF01113. DapB_N. 1 hit. [Graphical view]
PIRSF	PIRSF000161. DHPR. 1 hit.
TIGRFAMs	TIGR00036. DapB. 1 hit.
PROSITE	PS01298. DAPB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DAPB_THEEB

Accession

Primary (citable) accession number: Q8DHH2

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 22, 2003
Last sequence update:	March 1, 2003
Last modified:	January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program