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Q8DHB4

- PDXA_THEEB

UniProt

Q8DHB4 - PDXA_THEEB

Protein

4-hydroxythreonine-4-phosphate dehydrogenase

Gene

pdxA

Organism
Thermosynechococcus elongatus (strain BP-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).UniRule annotation

    Catalytic activityi

    4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH.

    Cofactori

    Binds 1 divalent metal cation per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei126 – 1261SubstrateUniRule annotation
    Metal bindingi161 – 1611Divalent metal cation; shared with dimeric partnerUniRule annotation
    Metal bindingi206 – 2061Divalent metal cation; shared with dimeric partnerUniRule annotation
    Metal bindingi272 – 2721Divalent metal cation; shared with dimeric partnerUniRule annotation
    Binding sitei280 – 2801SubstrateUniRule annotation
    Binding sitei289 – 2891SubstrateUniRule annotation
    Binding sitei298 – 2981SubstrateUniRule annotation

    GO - Molecular functioni

    1. 4-hydroxythreonine-4-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. pyridoxal phosphate biosynthetic process Source: UniProtKB-HAMAP
    2. pyridoxine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Pyridoxine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, NADP

    Enzyme and pathway databases

    UniPathwayiUPA00244; UER00312.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    4-hydroxythreonine-4-phosphate dehydrogenaseUniRule annotation (EC:1.1.1.262UniRule annotation)
    Alternative name(s):
    4-(phosphohydroxy)-L-threonine dehydrogenaseUniRule annotation
    Gene namesi
    Name:pdxAUniRule annotation
    Ordered Locus Names:tll2045
    OrganismiThermosynechococcus elongatus (strain BP-1)
    Taxonomic identifieri197221 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesThermosynechococcus
    ProteomesiUP000000440: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3413414-hydroxythreonine-4-phosphate dehydrogenasePRO_0000188831Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi197221.tll2045.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8DHB4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PdxA family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1995.
    HOGENOMiHOG000221591.
    KOiK00097.
    OMAiDTLFQDK.
    OrthoDBiEOG6GN6ZC.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    HAMAPiMF_00536. PdxA.
    InterProiIPR024084. IsoPropMal-DH-like_dom.
    IPR005255. PdxA.
    [Graphical view]
    PfamiPF04166. PdxA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00557. pdxA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8DHB4-1 [UniParc]FASTAAdd to Basket

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    MSLALTLGDP AGIGPEILLK ALAHLPSELL GQFFIAGTGQ VLEETYARLC    50
    QQGQVAIDPA QLQLWEHPLD EVIVPGRPSV ASGTASFAYL KTAIQRAIAG 100
    EVAGIVTAPI SKACWQAAGY SFPGQTEVLA HLTGTAHVGM LFLGRSPVTH 150
    WVLTTLLATT HIPLQAVPRA LTPEGLNEKL ALLIQFLRER RHLERPRIAI 200
    AGLNPHSGEQ GHLGQEEVTW LIPWLAAAQQ QYPEVELIGP VPPDTLWIGA 250
    ADAWWGRPAP ATAYDAYLAL YHDQGLIPVK MLAFREAVNT TIGLPFIRTS 300
    PDHGTAFDIA GTGVADPQSF LAAIAWAQTL SKGSVFPLTL A 341
    Length:341
    Mass (Da):36,500
    Last modified:March 1, 2003 - v1
    Checksum:i66DAC85253DE0D23
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000039 Genomic DNA. Translation: BAC09597.1.
    RefSeqiNP_682835.1. NC_004113.1.

    Genome annotation databases

    EnsemblBacteriaiBAC09597; BAC09597; BAC09597.
    GeneIDi1011601.
    KEGGitel:tll2045.
    PATRICi23929506. VBITheElo119873_2140.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000039 Genomic DNA. Translation: BAC09597.1 .
    RefSeqi NP_682835.1. NC_004113.1.

    3D structure databases

    ProteinModelPortali Q8DHB4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 197221.tll2045.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC09597 ; BAC09597 ; BAC09597 .
    GeneIDi 1011601.
    KEGGi tel:tll2045.
    PATRICi 23929506. VBITheElo119873_2140.

    Phylogenomic databases

    eggNOGi COG1995.
    HOGENOMi HOG000221591.
    KOi K00097.
    OMAi DTLFQDK.
    OrthoDBi EOG6GN6ZC.

    Enzyme and pathway databases

    UniPathwayi UPA00244 ; UER00312 .

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    HAMAPi MF_00536. PdxA.
    InterProi IPR024084. IsoPropMal-DH-like_dom.
    IPR005255. PdxA.
    [Graphical view ]
    Pfami PF04166. PdxA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00557. pdxA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BP-1.

    Entry informationi

    Entry nameiPDXA_THEEB
    AccessioniPrimary (citable) accession number: Q8DHB4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The active site is located at the dimer interface.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3