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Q8DHB4

- PDXA_THEEB

UniProt

Q8DHB4 - PDXA_THEEB

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Protein
4-hydroxythreonine-4-phosphate dehydrogenase
Gene
pdxA, tll2045
Organism
Thermosynechococcus elongatus (strain BP-1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) By similarity.UniRule annotation

Catalytic activityi

4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH.UniRule annotation

Cofactori

Binds 1 divalent metal cation per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei126 – 1261Substrate By similarity
Metal bindingi161 – 1611Divalent metal cation; shared with dimeric partner By similarity
Metal bindingi206 – 2061Divalent metal cation; shared with dimeric partner By similarity
Metal bindingi272 – 2721Divalent metal cation; shared with dimeric partner By similarity
Binding sitei280 – 2801Substrate By similarity
Binding sitei289 – 2891Substrate By similarity
Binding sitei298 – 2981Substrate By similarity

GO - Molecular functioni

  1. 4-hydroxythreonine-4-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. metal ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. pyridoxal phosphate biosynthetic process Source: UniProtKB-HAMAP
  2. pyridoxine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyridoxine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, NADP

Enzyme and pathway databases

UniPathwayiUPA00244; UER00312.

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxythreonine-4-phosphate dehydrogenase (EC:1.1.1.262)
Alternative name(s):
4-(phosphohydroxy)-L-threonine dehydrogenase
Gene namesi
Name:pdxA
Ordered Locus Names:tll2045
OrganismiThermosynechococcus elongatus (strain BP-1)
Taxonomic identifieri197221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesThermosynechococcus
ProteomesiUP000000440: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3413414-hydroxythreonine-4-phosphate dehydrogenaseUniRule annotation
PRO_0000188831Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi197221.tll2045.

Structurei

3D structure databases

ProteinModelPortaliQ8DHB4.

Family & Domainsi

Sequence similaritiesi

Belongs to the PdxA family.

Phylogenomic databases

eggNOGiCOG1995.
HOGENOMiHOG000221591.
KOiK00097.
OMAiDTLFQDK.
OrthoDBiEOG6GN6ZC.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
HAMAPiMF_00536. PdxA.
InterProiIPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view]
PfamiPF04166. PdxA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00557. pdxA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8DHB4-1 [UniParc]FASTAAdd to Basket

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MSLALTLGDP AGIGPEILLK ALAHLPSELL GQFFIAGTGQ VLEETYARLC    50
QQGQVAIDPA QLQLWEHPLD EVIVPGRPSV ASGTASFAYL KTAIQRAIAG 100
EVAGIVTAPI SKACWQAAGY SFPGQTEVLA HLTGTAHVGM LFLGRSPVTH 150
WVLTTLLATT HIPLQAVPRA LTPEGLNEKL ALLIQFLRER RHLERPRIAI 200
AGLNPHSGEQ GHLGQEEVTW LIPWLAAAQQ QYPEVELIGP VPPDTLWIGA 250
ADAWWGRPAP ATAYDAYLAL YHDQGLIPVK MLAFREAVNT TIGLPFIRTS 300
PDHGTAFDIA GTGVADPQSF LAAIAWAQTL SKGSVFPLTL A 341
Length:341
Mass (Da):36,500
Last modified:March 1, 2003 - v1
Checksum:i66DAC85253DE0D23
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000039 Genomic DNA. Translation: BAC09597.1.
RefSeqiNP_682835.1. NC_004113.1.

Genome annotation databases

EnsemblBacteriaiBAC09597; BAC09597; BAC09597.
GeneIDi1011601.
KEGGitel:tll2045.
PATRICi23929506. VBITheElo119873_2140.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000039 Genomic DNA. Translation: BAC09597.1 .
RefSeqi NP_682835.1. NC_004113.1.

3D structure databases

ProteinModelPortali Q8DHB4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 197221.tll2045.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC09597 ; BAC09597 ; BAC09597 .
GeneIDi 1011601.
KEGGi tel:tll2045.
PATRICi 23929506. VBITheElo119873_2140.

Phylogenomic databases

eggNOGi COG1995.
HOGENOMi HOG000221591.
KOi K00097.
OMAi DTLFQDK.
OrthoDBi EOG6GN6ZC.

Enzyme and pathway databases

UniPathwayi UPA00244 ; UER00312 .

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
HAMAPi MF_00536. PdxA.
InterProi IPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view ]
Pfami PF04166. PdxA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00557. pdxA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BP-1.

Entry informationi

Entry nameiPDXA_THEEB
AccessioniPrimary (citable) accession number: Q8DHB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2003
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The active site is located at the dimer interface By similarity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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