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Q8DH61

- SYL_THEEB

UniProt

Q8DH61 - SYL_THEEB

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Thermosynechococcus elongatus (strain BP-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei618 – 6181ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:tll2098
OrganismiThermosynechococcus elongatus (strain BP-1)
Taxonomic identifieri197221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesThermosynechococcus
ProteomesiUP000000440: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 857857Leucine--tRNA ligasePRO_0000152102Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi197221.tll2098.

Structurei

3D structure databases

ProteinModelPortaliQ8DH61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi615 – 6195"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8DH61-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDDRYDPQVI EAKWQQEWAA RQLDRTDTDP QKPKFYALSM FPYPSGNLHM
60 70 80 90 100
GHVRNYTITD VIARCRRMQG YRVLHPMGWD AFGLPAENAA IERGIHPRVW
110 120 130 140 150
TQQNIGQMRQ ELQRLGLSYD WEREVTTCHP DYYRWTQWLF LEFFEAGLAY
160 170 180 190 200
QKEAAVNWDP VDQTVLANEQ VDSEGRSWRS GALVERRLLK QWFLKITAYA
210 220 230 240 250
EELLNDLEQL TGWPERVKLM QANWIGQSRG AYLEFPIVGS DEKIGVFTTR
260 270 280 290 300
PDTVYGVTYV VLAPEHPLTL KVTTSRRRKT VEAFIASVQQ ESELERTAGD
310 320 330 340 350
RPKRGVATGG KALNPFTGEE IPIWIANYVL YEYGTGAVMG VPAHDERDFQ
360 370 380 390 400
FAKAHRLPIR QVIIPPDGKA STRLRAAYTE PGKLINSGQF DGMDSTAAKV
410 420 430 440 450
AITEYATAQG WGREHVQYRL RDWLISRQRY WGVPIPIIHC PQCGPVPVPR
460 470 480 490 500
SELPVLLPEE VEFTGRGPSP LAKLAAWRDV PCPKCGGPAQ RETDTMDTFI
510 520 530 540 550
DSSWYYFRYA DARNSEAPFD PAAIKDWLPV DQYVGGIEHA ILHLLYSRFF
560 570 580 590 600
TKVLRDRQLV HVSEPFQRLL TQGMVQGRTY KNPRTGKYVI PSRIADLNQP
610 620 630 640 650
TDPDTGEALE VVYEKMSKSK YNGVAPGDVI QQYGADTARM FILFKAPPEK
660 670 680 690 700
DLEWDDADVE GQFRFLNRVW RLVQTFKAKG GRLGQPLPAT LTKAEKDLRR
710 720 730 740 750
AIHTAIKEIS EDIEGDYQLN TAVAELMKLS NALSSADCYT SGVYSEGIQT
760 770 780 790 800
LLTLLAPFAP HISEELWHQL GGTDSIHRQP WPKADPTALV ADEITLVIQV
810 820 830 840 850
MGKTRGAIQV PATASQAELE EAAQHSEIGQ RYLAGKTIKK IIVVPGKLVN

FVLESSR
Length:857
Mass (Da):97,076
Last modified:March 1, 2003 - v1
Checksum:iA28EA8AFF7FEEAC6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000039 Genomic DNA. Translation: BAC09650.1.
RefSeqiNP_682888.1. NC_004113.1.

Genome annotation databases

EnsemblBacteriaiBAC09650; BAC09650; BAC09650.
GeneIDi1011511.
KEGGitel:tll2098.
PATRICi23929620. VBITheElo119873_2196.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000039 Genomic DNA. Translation: BAC09650.1 .
RefSeqi NP_682888.1. NC_004113.1.

3D structure databases

ProteinModelPortali Q8DH61.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 197221.tll2098.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC09650 ; BAC09650 ; BAC09650 .
GeneIDi 1011511.
KEGGi tel:tll2098.
PATRICi 23929620. VBITheElo119873_2196.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BP-1.

Entry informationi

Entry nameiSYL_THEEB
AccessioniPrimary (citable) accession number: Q8DH61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 1, 2003
Last modified: November 26, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3