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Q8DH61 (SYL_THEEB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:tll2098
OrganismThermosynechococcus elongatus (strain BP-1) [Reference proteome] [HAMAP]
Taxonomic identifier197221 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesThermosynechococcus

Protein attributes

Sequence length857 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 857857Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_0000152102

Regions

Motif42 – 5211"HIGH" region HAMAP-Rule MF_00049
Motif615 – 6195"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site6181ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8DH61 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: A28EA8AFF7FEEAC6

FASTA85797,076
        10         20         30         40         50         60 
MDDRYDPQVI EAKWQQEWAA RQLDRTDTDP QKPKFYALSM FPYPSGNLHM GHVRNYTITD 

        70         80         90        100        110        120 
VIARCRRMQG YRVLHPMGWD AFGLPAENAA IERGIHPRVW TQQNIGQMRQ ELQRLGLSYD 

       130        140        150        160        170        180 
WEREVTTCHP DYYRWTQWLF LEFFEAGLAY QKEAAVNWDP VDQTVLANEQ VDSEGRSWRS 

       190        200        210        220        230        240 
GALVERRLLK QWFLKITAYA EELLNDLEQL TGWPERVKLM QANWIGQSRG AYLEFPIVGS 

       250        260        270        280        290        300 
DEKIGVFTTR PDTVYGVTYV VLAPEHPLTL KVTTSRRRKT VEAFIASVQQ ESELERTAGD 

       310        320        330        340        350        360 
RPKRGVATGG KALNPFTGEE IPIWIANYVL YEYGTGAVMG VPAHDERDFQ FAKAHRLPIR 

       370        380        390        400        410        420 
QVIIPPDGKA STRLRAAYTE PGKLINSGQF DGMDSTAAKV AITEYATAQG WGREHVQYRL 

       430        440        450        460        470        480 
RDWLISRQRY WGVPIPIIHC PQCGPVPVPR SELPVLLPEE VEFTGRGPSP LAKLAAWRDV 

       490        500        510        520        530        540 
PCPKCGGPAQ RETDTMDTFI DSSWYYFRYA DARNSEAPFD PAAIKDWLPV DQYVGGIEHA 

       550        560        570        580        590        600 
ILHLLYSRFF TKVLRDRQLV HVSEPFQRLL TQGMVQGRTY KNPRTGKYVI PSRIADLNQP 

       610        620        630        640        650        660 
TDPDTGEALE VVYEKMSKSK YNGVAPGDVI QQYGADTARM FILFKAPPEK DLEWDDADVE 

       670        680        690        700        710        720 
GQFRFLNRVW RLVQTFKAKG GRLGQPLPAT LTKAEKDLRR AIHTAIKEIS EDIEGDYQLN 

       730        740        750        760        770        780 
TAVAELMKLS NALSSADCYT SGVYSEGIQT LLTLLAPFAP HISEELWHQL GGTDSIHRQP 

       790        800        810        820        830        840 
WPKADPTALV ADEITLVIQV MGKTRGAIQV PATASQAELE EAAQHSEIGQ RYLAGKTIKK 

       850 
IIVVPGKLVN FVLESSR 

« Hide

References

[1]"Complete genome structure of the thermophilic cyanobacterium Thermosynechococcus elongatus BP-1."
Nakamura Y., Kaneko T., Sato S., Ikeuchi M., Katoh H., Sasamoto S., Watanabe A., Iriguchi M., Kawashima K., Kimura T., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Nakazaki N., Shimpo S., Sugimoto M. expand/collapse author list , Takeuchi C., Yamada M., Tabata S.
DNA Res. 9:123-130(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BP-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000039 Genomic DNA. Translation: BAC09650.1.
RefSeqNP_682888.1. NC_004113.1.

3D structure databases

ProteinModelPortalQ8DH61.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING197221.tll2098.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC09650; BAC09650; BAC09650.
GeneID1011511.
KEGGtel:tll2098.
PATRIC23929620. VBITheElo119873_2196.

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200747.
KOK01869.
OMAHISHELW.
OrthoDBEOG63Z74X.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_THEEB
AccessionPrimary (citable) accession number: Q8DH61
Entry history
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries