Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8DH61

- SYL_THEEB

UniProt

Q8DH61 - SYL_THEEB

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Thermosynechococcus elongatus (strain BP-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei618 – 6181ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:tll2098
    OrganismiThermosynechococcus elongatus (strain BP-1)
    Taxonomic identifieri197221 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesThermosynechococcus
    ProteomesiUP000000440: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 857857Leucine--tRNA ligasePRO_0000152102Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi197221.tll2098.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8DH61.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi615 – 6195"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8DH61-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDDRYDPQVI EAKWQQEWAA RQLDRTDTDP QKPKFYALSM FPYPSGNLHM    50
    GHVRNYTITD VIARCRRMQG YRVLHPMGWD AFGLPAENAA IERGIHPRVW 100
    TQQNIGQMRQ ELQRLGLSYD WEREVTTCHP DYYRWTQWLF LEFFEAGLAY 150
    QKEAAVNWDP VDQTVLANEQ VDSEGRSWRS GALVERRLLK QWFLKITAYA 200
    EELLNDLEQL TGWPERVKLM QANWIGQSRG AYLEFPIVGS DEKIGVFTTR 250
    PDTVYGVTYV VLAPEHPLTL KVTTSRRRKT VEAFIASVQQ ESELERTAGD 300
    RPKRGVATGG KALNPFTGEE IPIWIANYVL YEYGTGAVMG VPAHDERDFQ 350
    FAKAHRLPIR QVIIPPDGKA STRLRAAYTE PGKLINSGQF DGMDSTAAKV 400
    AITEYATAQG WGREHVQYRL RDWLISRQRY WGVPIPIIHC PQCGPVPVPR 450
    SELPVLLPEE VEFTGRGPSP LAKLAAWRDV PCPKCGGPAQ RETDTMDTFI 500
    DSSWYYFRYA DARNSEAPFD PAAIKDWLPV DQYVGGIEHA ILHLLYSRFF 550
    TKVLRDRQLV HVSEPFQRLL TQGMVQGRTY KNPRTGKYVI PSRIADLNQP 600
    TDPDTGEALE VVYEKMSKSK YNGVAPGDVI QQYGADTARM FILFKAPPEK 650
    DLEWDDADVE GQFRFLNRVW RLVQTFKAKG GRLGQPLPAT LTKAEKDLRR 700
    AIHTAIKEIS EDIEGDYQLN TAVAELMKLS NALSSADCYT SGVYSEGIQT 750
    LLTLLAPFAP HISEELWHQL GGTDSIHRQP WPKADPTALV ADEITLVIQV 800
    MGKTRGAIQV PATASQAELE EAAQHSEIGQ RYLAGKTIKK IIVVPGKLVN 850
    FVLESSR 857
    Length:857
    Mass (Da):97,076
    Last modified:March 1, 2003 - v1
    Checksum:iA28EA8AFF7FEEAC6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000039 Genomic DNA. Translation: BAC09650.1.
    RefSeqiNP_682888.1. NC_004113.1.

    Genome annotation databases

    EnsemblBacteriaiBAC09650; BAC09650; BAC09650.
    GeneIDi1011511.
    KEGGitel:tll2098.
    PATRICi23929620. VBITheElo119873_2196.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000039 Genomic DNA. Translation: BAC09650.1 .
    RefSeqi NP_682888.1. NC_004113.1.

    3D structure databases

    ProteinModelPortali Q8DH61.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 197221.tll2098.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC09650 ; BAC09650 ; BAC09650 .
    GeneIDi 1011511.
    KEGGi tel:tll2098.
    PATRICi 23929620. VBITheElo119873_2196.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BP-1.

    Entry informationi

    Entry nameiSYL_THEEB
    AccessioniPrimary (citable) accession number: Q8DH61
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 25, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3