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Q8DH61

- SYL_THEEB

UniProt

Q8DH61 - SYL_THEEB

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Protein

Leucine--tRNA ligase

Gene
leuS, tll2098
Organism
Thermosynechococcus elongatus (strain BP-1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei618 – 6181ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:tll2098
OrganismiThermosynechococcus elongatus (strain BP-1)
Taxonomic identifieri197221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesThermosynechococcus
ProteomesiUP000000440: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 857857Leucine--tRNA ligaseUniRule annotationPRO_0000152102Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi197221.tll2098.

Structurei

3D structure databases

ProteinModelPortaliQ8DH61.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotationAdd
BLAST
Motifi615 – 6195"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8DH61-1 [UniParc]FASTAAdd to Basket

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MDDRYDPQVI EAKWQQEWAA RQLDRTDTDP QKPKFYALSM FPYPSGNLHM    50
GHVRNYTITD VIARCRRMQG YRVLHPMGWD AFGLPAENAA IERGIHPRVW 100
TQQNIGQMRQ ELQRLGLSYD WEREVTTCHP DYYRWTQWLF LEFFEAGLAY 150
QKEAAVNWDP VDQTVLANEQ VDSEGRSWRS GALVERRLLK QWFLKITAYA 200
EELLNDLEQL TGWPERVKLM QANWIGQSRG AYLEFPIVGS DEKIGVFTTR 250
PDTVYGVTYV VLAPEHPLTL KVTTSRRRKT VEAFIASVQQ ESELERTAGD 300
RPKRGVATGG KALNPFTGEE IPIWIANYVL YEYGTGAVMG VPAHDERDFQ 350
FAKAHRLPIR QVIIPPDGKA STRLRAAYTE PGKLINSGQF DGMDSTAAKV 400
AITEYATAQG WGREHVQYRL RDWLISRQRY WGVPIPIIHC PQCGPVPVPR 450
SELPVLLPEE VEFTGRGPSP LAKLAAWRDV PCPKCGGPAQ RETDTMDTFI 500
DSSWYYFRYA DARNSEAPFD PAAIKDWLPV DQYVGGIEHA ILHLLYSRFF 550
TKVLRDRQLV HVSEPFQRLL TQGMVQGRTY KNPRTGKYVI PSRIADLNQP 600
TDPDTGEALE VVYEKMSKSK YNGVAPGDVI QQYGADTARM FILFKAPPEK 650
DLEWDDADVE GQFRFLNRVW RLVQTFKAKG GRLGQPLPAT LTKAEKDLRR 700
AIHTAIKEIS EDIEGDYQLN TAVAELMKLS NALSSADCYT SGVYSEGIQT 750
LLTLLAPFAP HISEELWHQL GGTDSIHRQP WPKADPTALV ADEITLVIQV 800
MGKTRGAIQV PATASQAELE EAAQHSEIGQ RYLAGKTIKK IIVVPGKLVN 850
FVLESSR 857
Length:857
Mass (Da):97,076
Last modified:March 1, 2003 - v1
Checksum:iA28EA8AFF7FEEAC6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000039 Genomic DNA. Translation: BAC09650.1.
RefSeqiNP_682888.1. NC_004113.1.

Genome annotation databases

EnsemblBacteriaiBAC09650; BAC09650; BAC09650.
GeneIDi1011511.
KEGGitel:tll2098.
PATRICi23929620. VBITheElo119873_2196.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000039 Genomic DNA. Translation: BAC09650.1 .
RefSeqi NP_682888.1. NC_004113.1.

3D structure databases

ProteinModelPortali Q8DH61.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 197221.tll2098.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC09650 ; BAC09650 ; BAC09650 .
GeneIDi 1011511.
KEGGi tel:tll2098.
PATRICi 23929620. VBITheElo119873_2196.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BP-1.

Entry informationi

Entry nameiSYL_THEEB
AccessioniPrimary (citable) accession number: Q8DH61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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