Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q8DGU6 (HEMH_THEEB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:tlr2216
OrganismThermosynechococcus elongatus (strain BP-1)
Taxonomic identifier197221 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Chroococcales › Thermosynechococcus

Protein attributes

Sequence length388 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Sequence caution

The sequence BAC09768.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 388388Ferrochelatase HAMAP MF_00323
PRO_0000175215

Sites

Metal binding1971Iron By similarity
Metal binding2781Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8DGU6 [UniParc].

Last modified April 4, 2003. Version 2.
Checksum: 31D821310E4329A9

FASTA38843,876
        10         20         30         40         50         60 
MASQTGVLLL NLGGPDRPED VRPFLYNLFS DPEIIRLPFR WLQKPLAWFI STSRARRSQA 

        70         80         90        100        110        120 
NYAQIGGGSP LRRITEQQAR ALKDALEGIG IEANLYIGMR YWHPFTEEAI AQIKADQIRE 

       130        140        150        160        170        180 
LVILPLYPQF SISTSGSSFR LLESLWNQDP ELQKIRYTLI PSWYNHPGYV AAMADLIRQE 

       190        200        210        220        230        240 
LDRCPNPDEA VIFFSAHGVP KSYVTEAGDP YQEEIEACVR LIMAALNRPN AHVLAYQSRV 

       250        260        270        280        290        300 
GPVEWLQPYT EDVILELAAQ GVKTLVVVPI SFVSEHIETL QEIDIEYREI AAEAGIEVFR 

       310        320        330        340        350        360 
RVPALNDHNG FISALAQLVK EALAAPPRTF AEVNQSRKRV KLYPQERWEW GMTSAAERWN 

       370        380 
GRLAMLGFLA LMIELISGQG PLHMLGLL

« Hide

References

[1]"Complete genome structure of the thermophilic cyanobacterium Thermosynechococcus elongatus BP-1."
Nakamura Y., Kaneko T., Sato S., Ikeuchi M., Katoh H., Sasamoto S., Watanabe A., Iriguchi M., Kawashima K., Kimura T., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Nakazaki N., Shimpo S., Sugimoto M. expand/collapse author list , Takeuchi C., Yamada M., Tabata S.
DNA Res. 9:123-130(2002) [PubMed: 12240834] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BP-1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000039 Genomic DNA. Translation: BAC09768.1. Different initiation.
RefSeqNP_683006.1. NC_004113.1.

3D structure databases

ProteinModelPortalQ8DGU6.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8DGU6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1010757.
GenomeReviewsGene locus tlr2216 in contig BA000039_GR.
KEGGtel:tlr2216.
NMPDRfig|197221.1.peg.2215.
PATRIC23929878. VBITheElo119873_2324.

Phylogenomic databases

eggNOGCOG0276.
HOGENOMHBG697135.
OMALQKPLAW.
ProtClustDBPRK00035.

Enzyme and pathway databases

BioCycTELO197221:TLR2216-MONOMER.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR023329. Chlorophyll_a/b-bd_dom.
IPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
SUPFAMSSF103511. SSF103511. 1 hit.
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_THEEB
AccessionPrimary (citable) accession number: Q8DGU6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2003
Last sequence update: April 4, 2003
Last modified: January 25, 2012
This is version 61 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents