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Q8DGR2

- HISX_THEEB

UniProt

Q8DGR2 - HISX_THEEB

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Thermosynechococcus elongatus (strain BP-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei130 – 1301NADUniRule annotation
    Binding sitei192 – 1921NADUniRule annotation
    Binding sitei215 – 2151NADUniRule annotation
    Binding sitei238 – 2381SubstrateUniRule annotation
    Metal bindingi260 – 2601ZincUniRule annotation
    Binding sitei260 – 2601SubstrateUniRule annotation
    Metal bindingi263 – 2631ZincUniRule annotation
    Binding sitei263 – 2631SubstrateUniRule annotation
    Active sitei328 – 3281Proton acceptorUniRule annotation
    Active sitei329 – 3291Proton acceptorUniRule annotation
    Binding sitei329 – 3291SubstrateUniRule annotation
    Metal bindingi362 – 3621ZincUniRule annotation
    Binding sitei362 – 3621SubstrateUniRule annotation
    Binding sitei416 – 4161SubstrateUniRule annotation
    Metal bindingi421 – 4211ZincUniRule annotation
    Binding sitei421 – 4211SubstrateUniRule annotation

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
    Short name:
    HDHUniRule annotation
    Gene namesi
    Name:hisDUniRule annotation
    Ordered Locus Names:tll2252
    OrganismiThermosynechococcus elongatus (strain BP-1)
    Taxonomic identifieri197221 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesThermosynechococcus
    ProteomesiUP000000440: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 431431Histidinol dehydrogenasePRO_0000135862Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi197221.tll2252.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8DGR2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiYAAKLCG.
    OrthoDBiEOG6CVVCR.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8DGR2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLRIITQLTD LRAELRRICD RTDSGEMSEQ QATVEAILRR VAKDGDRALI    50
    EYTAQFDHID LTPETLRVKG DELDAAYQQV SKELLDAIRL AKQQIEAFHR 100
    QRVPKSWVQF GEDGVVLGKR YTAVDAAGLY VPGGRAAYPS TVLMNAIPAQ 150
    VAGVQRIVMV TPPGQGKGIN PAVLVAAQEA GIQEIYRVGG AQAIAALAYG 200
    TETIPRVDVI TGPGNLYVML AKKQVYGRVG IDSLAGPSEV LIIADEAAHP 250
    AQIAADLLAQ AEHDPLAAAI LLTPSLSLAK AVVTAVNEQL ADHPRRVLTE 300
    KAIAHYGLIG IVETLEQAVE LSNSFAPEHL ELEVEDPWSL VEQVRHAGAI 350
    FLGYSTPEAV GDYLAGPNHT LPTSGAARYA SALGVETFLK HSSIIQYTPA 400
    ALRKQGGAVM TLAETEGLIS HRDSVRLRLQ P 431
    Length:431
    Mass (Da):46,340
    Last modified:March 1, 2003 - v1
    Checksum:iE94C15E8A677677A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000039 Genomic DNA. Translation: BAC09804.1.
    RefSeqiNP_683042.1. NC_004113.1.
    WP_011058085.1. NC_004113.1.

    Genome annotation databases

    EnsemblBacteriaiBAC09804; BAC09804; BAC09804.
    GeneIDi1012296.
    KEGGitel:tll2252.
    PATRICi23929958. VBITheElo119873_2360.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000039 Genomic DNA. Translation: BAC09804.1 .
    RefSeqi NP_683042.1. NC_004113.1.
    WP_011058085.1. NC_004113.1.

    3D structure databases

    ProteinModelPortali Q8DGR2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 197221.tll2252.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC09804 ; BAC09804 ; BAC09804 .
    GeneIDi 1012296.
    KEGGi tel:tll2252.
    PATRICi 23929958. VBITheElo119873_2360.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi YAAKLCG.
    OrthoDBi EOG6CVVCR.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BP-1.

    Entry informationi

    Entry nameiHISX_THEEB
    AccessioniPrimary (citable) accession number: Q8DGR2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 25, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3