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Protein

2-phytyl-1,4-naphtoquinone methyltransferase

Gene

menG

Organism
Thermosynechococcus elongatus (strain BP-1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Methyltransferase required for the conversion of 2-phytyl-1,4-beta-naphthoquinone to phylloquinone.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + demethylphylloquinone = S-adenosyl-L-homocysteine + phylloquinone.UniRule annotation

Pathwayi: phylloquinone biosynthesis

This protein is involved in the pathway phylloquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway phylloquinone biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00995.

Names & Taxonomyi

Protein namesi
Recommended name:
2-phytyl-1,4-naphtoquinone methyltransferaseUniRule annotation (EC:2.1.1.n12UniRule annotation)
Alternative name(s):
Demethylphylloquinone methyltransferaseUniRule annotation
Gene namesi
Name:menGUniRule annotation
Ordered Locus Names:tll2373
OrganismiThermosynechococcus elongatus (strain BP-1)
Taxonomic identifieri197221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesThermosynechococcus
Proteomesi
  • UP000000440 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2252252-phytyl-1,4-naphtoquinone methyltransferasePRO_0000193340Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi197221.tll2373.

Structurei

3D structure databases

ProteinModelPortaliQ8DGE4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107UA9. Bacteria.
COG2226. LUCA.
HOGENOMiHOG000249463.
KOiK03183.
OMAiAILDFHR.
OrthoDBiEOG6M6JSB.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01813. MenG_UbiE_methyltr.
MF_01982. MenG_phylloquinone_subfam.
InterProiIPR032904. MenG.
IPR029063. SAM-dependent_MTases.
IPR004033. UbiE/COQ5_MeTrFase.
IPR023576. UbiE/COQ5_MeTrFase_CS.
[Graphical view]
PfamiPF01209. Ubie_methyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR01934. MenG_MenH_UbiE. 1 hit.
PROSITEiPS51608. SAM_MT_UBIE. 1 hit.
PS01183. UBIE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8DGE4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNIQALFER IAPLYDRLND QLSFGLHHVW KQMAVDWLEL PQGATALDLC
60 70 80 90 100
CGTGDLTRLL ARRVGRQGRV VGLDFAAAPL AIARQRSDHY PQIEWLQGDA
110 120 130 140 150
LAVPFAPQTF QGITIGYGLR NVVDIPQALR EMFRLLVPGG RAAILDFSHP
160 170 180 190 200
QTSALEQFQQ WYLQQWVVPT ARHYGLAAEY DYLWPSIQAF PTPPTLCALI
210 220
QQAGFERVKH YPLLGGLMAI TVAQK
Length:225
Mass (Da):25,250
Last modified:March 1, 2003 - v1
Checksum:iE86BA421A93D2F15
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000039 Genomic DNA. Translation: BAC09925.1.
RefSeqiNP_683163.1. NC_004113.1.
WP_011058206.1. NC_004113.1.

Genome annotation databases

EnsemblBacteriaiBAC09925; BAC09925; BAC09925.
GeneIDi1010979.
KEGGitel:tll2373.
PATRICi23930224. VBITheElo119873_2490.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000039 Genomic DNA. Translation: BAC09925.1.
RefSeqiNP_683163.1. NC_004113.1.
WP_011058206.1. NC_004113.1.

3D structure databases

ProteinModelPortaliQ8DGE4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi197221.tll2373.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC09925; BAC09925; BAC09925.
GeneIDi1010979.
KEGGitel:tll2373.
PATRICi23930224. VBITheElo119873_2490.

Phylogenomic databases

eggNOGiENOG4107UA9. Bacteria.
COG2226. LUCA.
HOGENOMiHOG000249463.
KOiK03183.
OMAiAILDFHR.
OrthoDBiEOG6M6JSB.

Enzyme and pathway databases

UniPathwayiUPA00995.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01813. MenG_UbiE_methyltr.
MF_01982. MenG_phylloquinone_subfam.
InterProiIPR032904. MenG.
IPR029063. SAM-dependent_MTases.
IPR004033. UbiE/COQ5_MeTrFase.
IPR023576. UbiE/COQ5_MeTrFase_CS.
[Graphical view]
PfamiPF01209. Ubie_methyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR01934. MenG_MenH_UbiE. 1 hit.
PROSITEiPS51608. SAM_MT_UBIE. 1 hit.
PS01183. UBIE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BP-1.

Entry informationi

Entry nameiMENG_THEEB
AccessioniPrimary (citable) accession number: Q8DGE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: March 1, 2003
Last modified: March 16, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.