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Q8DG73 (PANCY_THEEB) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional pantoate ligase/cytidylate kinase

Including the following 2 domains:

  1. Pantoate--beta-alanine ligase
    EC=6.3.2.1
    Alternative name(s):
    Pantoate-activating enzyme
    Pantothenate synthetase
  2. Cytidylate kinase
    Short name=CK
    EC=2.7.4.14
    Alternative name(s):
    Cytidine monophosphate kinase
    Short name=CMP kinase
Gene names
Name:panC/cmk
Ordered Locus Names:tll2450
OrganismThermosynechococcus elongatus (strain BP-1) [Reference proteome] [HAMAP]
Taxonomic identifier197221 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesThermosynechococcus

Protein attributes

Sequence length513 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate. HAMAP-Rule MF_00158

ATP + (d)CMP = ADP + (d)CDP. HAMAP-Rule MF_00158

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1. HAMAP-Rule MF_00158

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00158.

Sequence similarities

In the N-terminal section; belongs to the pantothenate synthetase family.

In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 513513Bifunctional pantoate ligase/cytidylate kinase HAMAP-Rule MF_00158
PRO_0000239794

Regions

Nucleotide binding295 – 3039ATP By similarity
Region1 – 282282Pantoate--beta-alanine ligase HAMAP-Rule MF_00158
Region283 – 513231Cytidylate kinase HAMAP-Rule MF_00158

Sequences

Sequence LengthMass (Da)Tools
Q8DG73 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 259DDF0476613222

FASTA51356,833
        10         20         30         40         50         60 
MGTFHRLTTT AGLQTALGTF SPATTVGFVP TMGALHGGHA ALIRRARQEC DVVVVSIFVN 

        70         80         90        100        110        120 
PLQFGPQEDL ERYPRALEAD TALCQQLGVD LLFVPSVAEL YPTGMKHLTV VEPPRELTEH 

       130        140        150        160        170        180 
LCGRSRPGHF RGVATIVLKL LHLVQPDRAY FGQKDAQQLA IIRRCVADLN LDVEIIGCPI 

       190        200        210        220        230        240 
VRDADGLALS SRNQYLSAEE RATALALSQS LEVAQAAFRQ GCWDASLLLA QVQDHLRQFP 

       250        260        270        280        290        300 
QLRLDYAELV HPQTLVPLER IETVGLLAIA GWVGQTRLID NCLLDRRRPI LAVDGPAGAG 

       310        320        330        340        350        360 
KSTVTRLAAQ ALGLRYLDTG AMYRAVTWWC LENNLDLHDE PAIVEAIAHC RLHLESPDPH 

       370        380        390        400        410        420 
QPTRVWINDR EVSQAIRSLE VTQRVSQIAA LRGVRRLMVQ QQRAIGAHGG IAAEGRDIGT 

       430        440        450        460        470        480 
HVFPEAGLKI FLTASPEERA QRRWQELQQQ GHCDLSYEEL LAQITARDTA DQQRPYAPFR 

       490        500        510 
KAADAIEVCT DNLGIDEVVS KIVHLYRSRF PQP 

« Hide

References

[1]"Complete genome structure of the thermophilic cyanobacterium Thermosynechococcus elongatus BP-1."
Nakamura Y., Kaneko T., Sato S., Ikeuchi M., Katoh H., Sasamoto S., Watanabe A., Iriguchi M., Kawashima K., Kimura T., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Nakazaki N., Shimpo S., Sugimoto M. expand/collapse author list , Takeuchi C., Yamada M., Tabata S.
DNA Res. 9:123-130(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BP-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000039 Genomic DNA. Translation: BAC10002.1.
RefSeqNP_683240.1. NC_004113.1.

3D structure databases

ProteinModelPortalQ8DG73.
SMRQ8DG73. Positions 7-284.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING197221.tll2450.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC10002; BAC10002; BAC10002.
GeneID1010535.
KEGGtel:tll2450.
PATRIC23930392. VBITheElo119873_2574.

Phylogenomic databases

eggNOGCOG0283.
HOGENOMHOG000233355.
KOK13799.
OMALGEKDWQ.
OrthoDBEOG6Z6FZ4.

Enzyme and pathway databases

UniPathwayUPA00028; UER00005.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00158. PanC.
MF_00238. Cytidyl_kinase_type1.
MF_01349. PanCY.
InterProIPR004821. Cyt_trans-like.
IPR003136. Cytidylate_kin.
IPR011994. Cytidylate_kinase_dom.
IPR027417. P-loop_NTPase.
IPR003721. Pantoate_ligase.
IPR024894. Pantoate_ligase/cytidylate_kin.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERPTHR21299:SF2. PTHR21299:SF2. 1 hit.
PfamPF02224. Cytidylate_kin. 1 hit.
PF02569. Pantoate_ligase. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00017. cmk. 1 hit.
TIGR00125. cyt_tran_rel. 1 hit.
TIGR00018. panC. 1 hit.
ProtoNetSearch...

Entry information

Entry namePANCY_THEEB
AccessionPrimary (citable) accession number: Q8DG73
Entry history
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: March 1, 2003
Last modified: June 11, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways