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Q8DG73

- PANCY_THEEB

UniProt

Q8DG73 - PANCY_THEEB

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Protein

Bifunctional pantoate ligase/cytidylate kinase

Gene

panC/cmk

Organism
Thermosynechococcus elongatus (strain BP-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.
ATP + (d)CMP = ADP + (d)CDP.

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi295 – 3039ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. cytidylate kinase activity Source: UniProtKB-HAMAP
  3. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
  2. pyrimidine nucleotide metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Ligase, Transferase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional pantoate ligase/cytidylate kinase
Including the following 2 domains:
Pantoate--beta-alanine ligase (EC:6.3.2.1)
Alternative name(s):
Pantoate-activating enzyme
Pantothenate synthetase
Cytidylate kinase (EC:2.7.4.14)
Short name:
CK
Alternative name(s):
Cytidine monophosphate kinase
Short name:
CMP kinase
Gene namesi
Name:panC/cmk
Ordered Locus Names:tll2450
OrganismiThermosynechococcus elongatus (strain BP-1)
Taxonomic identifieri197221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesThermosynechococcus
ProteomesiUP000000440: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 513513Bifunctional pantoate ligase/cytidylate kinasePRO_0000239794Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi197221.tll2450.

Structurei

3D structure databases

ProteinModelPortaliQ8DG73.
SMRiQ8DG73. Positions 7-284.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 282282Pantoate--beta-alanine ligaseAdd
BLAST
Regioni283 – 513231Cytidylate kinaseAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the pantothenate synthetase family.Curated
In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily.Curated

Phylogenomic databases

eggNOGiCOG0283.
HOGENOMiHOG000233355.
KOiK13799.
OMAiLGEKDWQ.
OrthoDBiEOG6Z6FZ4.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
MF_00238. Cytidyl_kinase_type1.
MF_01349. PanCY.
InterProiIPR004821. Cyt_trans-like.
IPR003136. Cytidylate_kin.
IPR011994. Cytidylate_kinase_dom.
IPR027417. P-loop_NTPase.
IPR003721. Pantoate_ligase.
IPR024894. Pantoate_ligase/cytidylate_kin.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF2. PTHR21299:SF2. 1 hit.
PfamiPF02224. Cytidylate_kin. 1 hit.
PF02569. Pantoate_ligase. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00017. cmk. 1 hit.
TIGR00125. cyt_tran_rel. 1 hit.
TIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8DG73-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGTFHRLTTT AGLQTALGTF SPATTVGFVP TMGALHGGHA ALIRRARQEC
60 70 80 90 100
DVVVVSIFVN PLQFGPQEDL ERYPRALEAD TALCQQLGVD LLFVPSVAEL
110 120 130 140 150
YPTGMKHLTV VEPPRELTEH LCGRSRPGHF RGVATIVLKL LHLVQPDRAY
160 170 180 190 200
FGQKDAQQLA IIRRCVADLN LDVEIIGCPI VRDADGLALS SRNQYLSAEE
210 220 230 240 250
RATALALSQS LEVAQAAFRQ GCWDASLLLA QVQDHLRQFP QLRLDYAELV
260 270 280 290 300
HPQTLVPLER IETVGLLAIA GWVGQTRLID NCLLDRRRPI LAVDGPAGAG
310 320 330 340 350
KSTVTRLAAQ ALGLRYLDTG AMYRAVTWWC LENNLDLHDE PAIVEAIAHC
360 370 380 390 400
RLHLESPDPH QPTRVWINDR EVSQAIRSLE VTQRVSQIAA LRGVRRLMVQ
410 420 430 440 450
QQRAIGAHGG IAAEGRDIGT HVFPEAGLKI FLTASPEERA QRRWQELQQQ
460 470 480 490 500
GHCDLSYEEL LAQITARDTA DQQRPYAPFR KAADAIEVCT DNLGIDEVVS
510
KIVHLYRSRF PQP
Length:513
Mass (Da):56,833
Last modified:March 1, 2003 - v1
Checksum:i259DDF0476613222
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000039 Genomic DNA. Translation: BAC10002.1.
RefSeqiNP_683240.1. NC_004113.1.

Genome annotation databases

EnsemblBacteriaiBAC10002; BAC10002; BAC10002.
GeneIDi1010535.
KEGGitel:tll2450.
PATRICi23930392. VBITheElo119873_2574.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000039 Genomic DNA. Translation: BAC10002.1 .
RefSeqi NP_683240.1. NC_004113.1.

3D structure databases

ProteinModelPortali Q8DG73.
SMRi Q8DG73. Positions 7-284.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 197221.tll2450.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC10002 ; BAC10002 ; BAC10002 .
GeneIDi 1010535.
KEGGi tel:tll2450.
PATRICi 23930392. VBITheElo119873_2574.

Phylogenomic databases

eggNOGi COG0283.
HOGENOMi HOG000233355.
KOi K13799.
OMAi LGEKDWQ.
OrthoDBi EOG6Z6FZ4.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
MF_00238. Cytidyl_kinase_type1.
MF_01349. PanCY.
InterProi IPR004821. Cyt_trans-like.
IPR003136. Cytidylate_kin.
IPR011994. Cytidylate_kinase_dom.
IPR027417. P-loop_NTPase.
IPR003721. Pantoate_ligase.
IPR024894. Pantoate_ligase/cytidylate_kin.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR21299:SF2. PTHR21299:SF2. 1 hit.
Pfami PF02224. Cytidylate_kin. 1 hit.
PF02569. Pantoate_ligase. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00017. cmk. 1 hit.
TIGR00125. cyt_tran_rel. 1 hit.
TIGR00018. panC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BP-1.

Entry informationi

Entry nameiPANCY_THEEB
AccessioniPrimary (citable) accession number: Q8DG73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3