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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Vibrio vulnificus (strain CMCP6)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei620ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciVVUL216895:G1GJ4-274-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:VV1_0272
OrganismiVibrio vulnificus (strain CMCP6)
Taxonomic identifieri216895 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001521151 – 857Leucine--tRNA ligaseAdd BLAST857

Proteomic databases

PRIDEiQ8DFE2

Structurei

3D structure databases

ProteinModelPortaliQ8DFE2
SMRiQ8DFE2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 52"HIGH" regionAdd BLAST11
Motifi617 – 621"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 3 hits
PF13603 tRNA-synt_1_2, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q8DFE2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQEQYNPQDI EQKVQQHWDN NKTFVVTEDP TKEKFYCLSM FPYPSGRLHM
60 70 80 90 100
GHVRNYTIGD VVSRFQRLQG KNVMQPIGWD AFGLPAENAA VKNNTAPAPW
110 120 130 140 150
TYENIEYMKN QLKLLGFGYD WNREFATCTP EYYRWEQEFF TKLYEKGLVY
160 170 180 190 200
KKTSSVNWCP NDQTVLANEQ VEDGCCWRCD TPVEQKEIPQ WFIKITEYAQ
210 220 230 240 250
ELLDDLDKLE GWPEMVKTMQ RNWIGRSEGV ELKFEVKGQQ DLEVYTTRPD
260 270 280 290 300
TLMGVTYVGI AAGHPLAKIA AENNPELAAF IEECKNTKVA EAELATMEKK
310 320 330 340 350
GMATGLTAIH PLNGREVPVY VANFVLMDYG TGAVMAVPAH DQRDFEFATK
360 370 380 390 400
YGLDIIPVIK PIDGSELDIS EAAYTEKGVL FDSGEFDGLE FQAAFDAIAA
410 420 430 440 450
KLEAEGKGTK TVNFRLRDWG VSRQRYWGAP IPMVTTEDGQ VHPVPADQLP
460 470 480 490 500
VILPEDVVMD GVTSPIKADK EWAKTTFNGE PALRETDTFD TFMESSWYYA
510 520 530 540 550
RYCSPQADDI LDPEKANYWL PVDQYIGGIE HACMHLLYSR FFHKLLRDAG
560 570 580 590 600
YVTSDEPFKQ LLCQGMVLAD AFYYTNDKGG KEWVSPTEVK VERDGKGRIT
610 620 630 640 650
SAVDNEGRNV EHSGMIKMSK SKNNGIDPQE MVDKYGADTV RLFMMFASPA
660 670 680 690 700
DMTLEWQESG VEGANRFLKR VWKLVNEHTS KGAAEAVDAA ALSGDQKALR
710 720 730 740 750
RDVHKTIAKV TDDVARRQTF NTAIAAVMEL MNKLAKAPQE SAQDRAILDE
760 770 780 790 800
ALKAVVAMLY PITPHICFEM WTALGQQDID NASWPTYDEQ ALVEDEKLIV
810 820 830 840 850
VQVNGKVRGK ITVAADATKE QVEEIGLNEE NVSKHLDGVT IRKVIYVPGK

LLSIVAN
Length:857
Mass (Da):96,677
Last modified:March 1, 2003 - v1
Checksum:iDD9EAFE51BA20E77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016795 Genomic DNA Translation: AAO08806.1
RefSeqiWP_011078381.1, NC_004459.3

Genome annotation databases

EnsemblBacteriaiAAO08806; AAO08806; VV1_0272
KEGGivvu:VV1_0272

Similar proteinsi

Entry informationi

Entry nameiSYL_VIBVU
AccessioniPrimary (citable) accession number: Q8DFE2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

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