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Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Vibrio vulnificus (strain CMCP6)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (Probable).1 Publication

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

a metal cationUniRule annotationNote: Binds 2 metal cations per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi21Metal cation 1UniRule annotation1
Metal bindingi23Metal cation 1UniRule annotation1
Binding sitei23cAMPUniRule annotation1
Metal bindingi63Metal cation 1UniRule annotation1
Metal bindingi63Metal cation 2UniRule annotation1
Binding sitei63cAMPUniRule annotation1
Metal bindingi93Metal cation 2UniRule annotation1
Metal bindingi163Metal cation 2UniRule annotation1
Metal bindingi202Metal cation 2UniRule annotation1
Metal bindingi204Metal cation 1UniRule annotation1
Binding sitei204cAMPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi93 – 94cAMPUniRule annotation2

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.53UniRule annotation)
Short name:
3',5'-cyclic AMP phosphodiesteraseUniRule annotation
Short name:
cAMP phosphodiesteraseUniRule annotation
Gene namesi
Name:cpdAUniRule annotation
Ordered Locus Names:VV1_0608
OrganismiVibrio vulnificus (strain CMCP6)
Taxonomic identifieri216895 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Pathology & Biotechi

Disruption phenotypei

Mutants show increased levels of cellular cAMP.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004133831 – 2743',5'-cyclic adenosine monophosphate phosphodiesterase CpdAAdd BLAST274

Expressioni

Inductioni

Positively regulated by the cAMP-CRP complex.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi216895.VV1_0608.

Structurei

3D structure databases

ProteinModelPortaliQ8DEI1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41070EG. Bacteria.
COG1409. LUCA.
HOGENOMiHOG000238351.
KOiK03651.
OMAiDPHLFKD.
OrthoDBiPOG091H05L5.

Family and domain databases

CDDicd07402. MPP_GpdQ. 1 hit.
Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR013622. CpdA_C.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PANTHERiPTHR12905:SF7. PTHR12905:SF7. 2 hits.
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
ProDomiPD587589. Calcineurin-like_phos_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8DEI1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQHTSSDTLS ENSIKLLQIT DTHLFASDEG SLLSVKTLQS FQAVVEQVMA
60 70 80 90 100
RHVEFDYLLA TGDISQDHSA ASYQRFADGI APLEKACFWL PGNHDYKPNM
110 120 130 140 150
SSVLPSPQIT TPEQVELNAH WQLILLDSQV VGVPHGRLSD QQLLMLEHHL
160 170 180 190 200
QASPEKNTLI LLHHHPLLVG SAWLDQHTLK DAEAFWQIVE RFPMVKGIVC
210 220 230 240 250
GHVHQDMNVM HKGIRVMATP STCVQFKPKS DDFALDTVSP GWRELTLHAN
260 270
GEITTQVQRL ASGSFLPDFT SSGY
Length:274
Mass (Da):30,578
Last modified:March 1, 2003 - v1
Checksum:i742F2E48490227E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016795 Genomic DNA. Translation: AAO09123.1.
RefSeqiWP_011078692.1. NC_004459.3.

Genome annotation databases

EnsemblBacteriaiAAO09123; AAO09123; VV1_0608.
KEGGivvu:VV1_0608.
PATRICi20158034. VBIVibVul94426_0588.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016795 Genomic DNA. Translation: AAO09123.1.
RefSeqiWP_011078692.1. NC_004459.3.

3D structure databases

ProteinModelPortaliQ8DEI1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi216895.VV1_0608.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO09123; AAO09123; VV1_0608.
KEGGivvu:VV1_0608.
PATRICi20158034. VBIVibVul94426_0588.

Phylogenomic databases

eggNOGiENOG41070EG. Bacteria.
COG1409. LUCA.
HOGENOMiHOG000238351.
KOiK03651.
OMAiDPHLFKD.
OrthoDBiPOG091H05L5.

Family and domain databases

CDDicd07402. MPP_GpdQ. 1 hit.
Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR013622. CpdA_C.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PANTHERiPTHR12905:SF7. PTHR12905:SF7. 2 hits.
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
ProDomiPD587589. Calcineurin-like_phos_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF56300. SSF56300. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCPDA_VIBVU
AccessioniPrimary (citable) accession number: Q8DEI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.