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Q8DEI1

- CPDA_VIBVU

UniProt

Q8DEI1 - CPDA_VIBVU

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Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Vibrio vulnificus (strain CMCP6)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (Probable).1 Publication

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

Binds 2 metal cations per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi21 – 211Metal cation 1UniRule annotation
Metal bindingi23 – 231Metal cation 1UniRule annotation
Binding sitei23 – 231cAMPUniRule annotation
Metal bindingi63 – 631Metal cation 1UniRule annotation
Metal bindingi63 – 631Metal cation 2UniRule annotation
Binding sitei63 – 631cAMPUniRule annotation
Metal bindingi93 – 931Metal cation 2UniRule annotation
Metal bindingi163 – 1631Metal cation 2UniRule annotation
Metal bindingi202 – 2021Metal cation 2UniRule annotation
Metal bindingi204 – 2041Metal cation 1UniRule annotation
Binding sitei204 – 2041cAMPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi93 – 942cAMPUniRule annotation

GO - Molecular functioni

  1. 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-HAMAP
  3. nucleotide binding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciVVUL216895:GIYM-565-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.17UniRule annotation)
Short name:
3',5'-cyclic AMP phosphodiesteraseUniRule annotation
Short name:
cAMP phosphodiesteraseUniRule annotation
Gene namesi
Name:cpdAUniRule annotation
Ordered Locus Names:VV1_0608
OrganismiVibrio vulnificus (strain CMCP6)
Taxonomic identifieri216895 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000002275: Chromosome 1

Pathology & Biotechi

Disruption phenotypei

Mutants show increased levels of cellular cAMP.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2742743',5'-cyclic adenosine monophosphate phosphodiesterase CpdAPRO_0000413383Add
BLAST

Expressioni

Inductioni

Positively regulated by the cAMP-CRP complex.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi216895.VV1_0608.

Structurei

3D structure databases

ProteinModelPortaliQ8DEI1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1409.
HOGENOMiHOG000238351.
KOiK03651.
OMAiWREIELH.
OrthoDBiEOG6QG8GQ.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA.
InterProiIPR013622. Calcineurin-like_phos_C.
IPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
ProDomiPD587589. Calcineurin-like_phos_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8DEI1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQHTSSDTLS ENSIKLLQIT DTHLFASDEG SLLSVKTLQS FQAVVEQVMA
60 70 80 90 100
RHVEFDYLLA TGDISQDHSA ASYQRFADGI APLEKACFWL PGNHDYKPNM
110 120 130 140 150
SSVLPSPQIT TPEQVELNAH WQLILLDSQV VGVPHGRLSD QQLLMLEHHL
160 170 180 190 200
QASPEKNTLI LLHHHPLLVG SAWLDQHTLK DAEAFWQIVE RFPMVKGIVC
210 220 230 240 250
GHVHQDMNVM HKGIRVMATP STCVQFKPKS DDFALDTVSP GWRELTLHAN
260 270
GEITTQVQRL ASGSFLPDFT SSGY
Length:274
Mass (Da):30,578
Last modified:March 1, 2003 - v1
Checksum:i742F2E48490227E7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016795 Genomic DNA. Translation: AAO09123.1.
RefSeqiNP_759596.1. NC_004459.3.

Genome annotation databases

EnsemblBacteriaiAAO09123; AAO09123; VV1_0608.
GeneIDi1177558.
KEGGivvu:VV1_0608.
PATRICi20158034. VBIVibVul94426_0588.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016795 Genomic DNA. Translation: AAO09123.1 .
RefSeqi NP_759596.1. NC_004459.3.

3D structure databases

ProteinModelPortali Q8DEI1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 216895.VV1_0608.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO09123 ; AAO09123 ; VV1_0608 .
GeneIDi 1177558.
KEGGi vvu:VV1_0608.
PATRICi 20158034. VBIVibVul94426_0588.

Phylogenomic databases

eggNOGi COG1409.
HOGENOMi HOG000238351.
KOi K03651.
OMAi WREIELH.
OrthoDBi EOG6QG8GQ.

Enzyme and pathway databases

BioCyci VVUL216895:GIYM-565-MONOMER.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
HAMAPi MF_00905. cAMP_phophodiest_CpdA.
InterProi IPR013622. Calcineurin-like_phos_C.
IPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
ProDomi PD587589. Calcineurin-like_phos_C. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF56300. SSF56300. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete genome sequence of Vibrio vulnificus CMCP6."
    Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E.
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CMCP6.
  2. "Expression of the cpdA gene, encoding a 3',5'-cyclic AMP (cAMP) phosphodiesterase, is positively regulated by the cAMP-cAMP receptor protein complex."
    Kim H.S., Kim S.M., Lee H.J., Park S.J., Lee K.H.
    J. Bacteriol. 191:922-930(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION, DISRUPTION PHENOTYPE.
    Strain: ATCC 29307 / CDC A8694.

Entry informationi

Entry nameiCPDA_VIBVU
AccessioniPrimary (citable) accession number: Q8DEI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: March 1, 2003
Last modified: October 1, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3