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Q8DEI1

- CPDA_VIBVU

UniProt

Q8DEI1 - CPDA_VIBVU

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Protein
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA
Gene
cpdA, VV1_0608
Organism
Vibrio vulnificus (strain CMCP6)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes Inferred.1 Publication

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

Binds 2 metal cations per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi21 – 211Metal cation 1 By similarity
Metal bindingi23 – 231Metal cation 1 By similarity
Binding sitei23 – 231cAMP By similarity
Metal bindingi63 – 631Metal cation 1 By similarity
Metal bindingi63 – 631Metal cation 2 By similarity
Binding sitei63 – 631cAMP By similarity
Metal bindingi93 – 931Metal cation 2 By similarity
Metal bindingi163 – 1631Metal cation 2 By similarity
Metal bindingi202 – 2021Metal cation 2 By similarity
Metal bindingi204 – 2041Metal cation 1 By similarity
Binding sitei204 – 2041cAMP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi93 – 942cAMP By similarity

GO - Molecular functioni

  1. 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-HAMAP
  3. nucleotide binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    cAMP, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciVVUL216895:GIYM-565-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA (EC:3.1.4.17)
    Short name:
    3',5'-cyclic AMP phosphodiesterase
    Short name:
    cAMP phosphodiesterase
    Gene namesi
    Name:cpdA
    Ordered Locus Names:VV1_0608
    OrganismiVibrio vulnificus (strain CMCP6)
    Taxonomic identifieri216895 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000002275: Chromosome 1

    Pathology & Biotechi

    Disruption phenotypei

    Mutants show increased levels of cellular cAMP.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2742743',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation
    PRO_0000413383Add
    BLAST

    Expressioni

    Inductioni

    Positively regulated by the cAMP-CRP complex.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi216895.VV1_0608.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8DEI1.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1409.
    HOGENOMiHOG000238351.
    KOiK03651.
    OMAiWREIELH.
    OrthoDBiEOG6QG8GQ.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    HAMAPiMF_00905. cAMP_phophodiest_CpdA.
    InterProiIPR013622. Calcineurin-like_phos_C.
    IPR004843. Calcineurin-like_PHP_apaH.
    IPR026575. cAMP_Pdiest_CpdA.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    ProDomiPD587589. Calcineurin-like_phos_C. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF56300. SSF56300. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8DEI1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQHTSSDTLS ENSIKLLQIT DTHLFASDEG SLLSVKTLQS FQAVVEQVMA    50
    RHVEFDYLLA TGDISQDHSA ASYQRFADGI APLEKACFWL PGNHDYKPNM 100
    SSVLPSPQIT TPEQVELNAH WQLILLDSQV VGVPHGRLSD QQLLMLEHHL 150
    QASPEKNTLI LLHHHPLLVG SAWLDQHTLK DAEAFWQIVE RFPMVKGIVC 200
    GHVHQDMNVM HKGIRVMATP STCVQFKPKS DDFALDTVSP GWRELTLHAN 250
    GEITTQVQRL ASGSFLPDFT SSGY 274
    Length:274
    Mass (Da):30,578
    Last modified:March 1, 2003 - v1
    Checksum:i742F2E48490227E7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016795 Genomic DNA. Translation: AAO09123.1.
    RefSeqiNP_759596.1. NC_004459.3.

    Genome annotation databases

    EnsemblBacteriaiAAO09123; AAO09123; VV1_0608.
    GeneIDi1177558.
    KEGGivvu:VV1_0608.
    PATRICi20158034. VBIVibVul94426_0588.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016795 Genomic DNA. Translation: AAO09123.1 .
    RefSeqi NP_759596.1. NC_004459.3.

    3D structure databases

    ProteinModelPortali Q8DEI1.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 216895.VV1_0608.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO09123 ; AAO09123 ; VV1_0608 .
    GeneIDi 1177558.
    KEGGi vvu:VV1_0608.
    PATRICi 20158034. VBIVibVul94426_0588.

    Phylogenomic databases

    eggNOGi COG1409.
    HOGENOMi HOG000238351.
    KOi K03651.
    OMAi WREIELH.
    OrthoDBi EOG6QG8GQ.

    Enzyme and pathway databases

    BioCyci VVUL216895:GIYM-565-MONOMER.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    HAMAPi MF_00905. cAMP_phophodiest_CpdA.
    InterProi IPR013622. Calcineurin-like_phos_C.
    IPR004843. Calcineurin-like_PHP_apaH.
    IPR026575. cAMP_Pdiest_CpdA.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    ProDomi PD587589. Calcineurin-like_phos_C. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "Complete genome sequence of Vibrio vulnificus CMCP6."
      Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E.
      Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CMCP6.
    2. "Expression of the cpdA gene, encoding a 3',5'-cyclic AMP (cAMP) phosphodiesterase, is positively regulated by the cAMP-cAMP receptor protein complex."
      Kim H.S., Kim S.M., Lee H.J., Park S.J., Lee K.H.
      J. Bacteriol. 191:922-930(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION, DISRUPTION PHENOTYPE.
      Strain: ATCC 29307 / CDC A8694.

    Entry informationi

    Entry nameiCPDA_VIBVU
    AccessioniPrimary (citable) accession number: Q8DEI1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2011
    Last sequence update: March 1, 2003
    Last modified: June 11, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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