ID   MTLD_VIBVU              Reviewed;         382 AA.
AC   Q8DEF5;
DT   23-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   16-JUN-2009, entry version 33.
DE   RecName: Full=Mannitol-1-phosphate 5-dehydrogenase;
DE            EC=1.1.1.17;
GN   Name=mtlD; OrderedLocusNames=VV1_0639;
OS   Vibrio vulnificus.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales;
OC   Vibrionaceae; Vibrio.
OX   NCBI_TaxID=672;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CMCP6;
RA   Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H.,
RA   Choy H.E.;
RT   "Complete genome sequence of Vibrio vulnificus CMCP6.";
RL   Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: D-mannitol 1-phosphate + NAD(+) = D-fructose
CC       6-phosphate + NADH.
CC   -!- SIMILARITY: Belongs to the mannitol dehydrogenase family.
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DR   EMBL; AE016795; AAO09152.1; -; Genomic_DNA.
DR   RefSeq; NP_759625.1; -.
DR   GeneID; 1177588; -.
DR   GenomeReviews; AE016795_GR; VV1_0639.
DR   KEGG; vvu:VV1_0639; -.
DR   HOGENOM; Q8DEF5; -.
DR   OMA; Q8DEF5; VDRIVPN.
DR   BioCyc; VVUL216895:VV1_0639-MON; -.
DR   BRENDA; 1.1.1.17; 277169.
DR   GO; GO:0050662; F:coenzyme binding; IEA:InterPro.
DR   GO; GO:0008926; F:mannitol-1-phosphate 5-dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00196; -; 1.
DR   InterPro; IPR013328; DH_multihelical.
DR   InterPro; IPR013118; Mannitol_DH_C.
DR   InterPro; IPR000669; Mannitol_DH_core.
DR   InterPro; IPR013131; Mannitol_DH_N.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Gene3D; G3DSA:1.10.1040.10; Opine_DH; 1.
DR   Pfam; PF01232; Mannitol_dh; 1.
DR   Pfam; PF08125; Mannitol_dh_C; 1.
DR   PRINTS; PR00084; MTLDHDRGNASE.
DR   PROSITE; PS00974; MANNITOL_DHGENASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome; NAD; Oxidoreductase.
FT   CHAIN         1    382       Mannitol-1-phosphate 5-dehydrogenase.
FT                                /FTId=PRO_0000170731.
FT   NP_BIND       4     15       NAD (By similarity).
SQ   SEQUENCE   382 AA;  41966 MW;  F031ADCEF350DDCA CRC64;
     MKNAVHFGAG NIGRGFIGKL LADANVAVTF ADVDAPLVDQ LSHKQEYKVK VVGSECQIDT
     VTHVTAVNSA SEEVIDRIVQ TDLVTTAVGP NVLDIIAKTI AQGIAKRFAA GNLAPLNIIA
     CENMVRGTTH LKGEVYKHLD ASLHAQADEL VGFVDSAVDR IVPPAEAAND DPLEVTVESF
     SEWIVDEQQF KGEVPSIAGM EKTHNLMAFV ERKLFTLNTG HCITAYLGCL QGHRTIREAI
     ENPAIRDQVK QAMMESGEVL IRRYGFDREM HQAYIEKILA RFANPFLVDE VDRVGRQPIR
     KLGMNDRLIK PLLGTIEFGT ANQHLLKGIA AALKYQNDSD PQAVELQRSL QQVGVKKTLA
     KYTSLAEDSV EVAKIETLYN QL
//