Q8DEF5 (MTLD_VIBVU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mannitol-1-phosphate 5-dehydrogenase
EC=1.1.1.17

Gene names

Name:	mtlD
Ordered Locus Names:	VV1_0639

Organism

Vibrio vulnificus [Complete proteome] [HAMAP]

Taxonomic identifier

672 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length	382 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH. HAMAP MF_00196
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 382	382	Mannitol-1-phosphate 5-dehydrogenase HAMAP MF_00196		PRO_0000170731
Regions
	Nucleotide binding	4 – 15	12	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8DEF5 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: F031ADCEF350DDCA	FASTA	382	41,966
	10 20 30 40 50 60 MKNAVHFGAG NIGRGFIGKL LADANVAVTF ADVDAPLVDQ LSHKQEYKVK VVGSECQIDT 70 80 90 100 110 120 VTHVTAVNSA SEEVIDRIVQ TDLVTTAVGP NVLDIIAKTI AQGIAKRFAA GNLAPLNIIA 130 140 150 160 170 180 CENMVRGTTH LKGEVYKHLD ASLHAQADEL VGFVDSAVDR IVPPAEAAND DPLEVTVESF 190 200 210 220 230 240 SEWIVDEQQF KGEVPSIAGM EKTHNLMAFV ERKLFTLNTG HCITAYLGCL QGHRTIREAI 250 260 270 280 290 300 ENPAIRDQVK QAMMESGEVL IRRYGFDREM HQAYIEKILA RFANPFLVDE VDRVGRQPIR 310 320 330 340 350 360 KLGMNDRLIK PLLGTIEFGT ANQHLLKGIA AALKYQNDSD PQAVELQRSL QQVGVKKTLA 370 380 KYTSLAEDSV EVAKIETLYN QL

References

[1]	"Complete genome sequence of Vibrio vulnificus CMCP6." Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E. Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CMCP6.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016795 Genomic DNA. Translation: AAO09152.1.
RefSeq	NP_759625.1. NC_004459.3.
3D structure databases
ProteinModelPortal	Q8DEF5.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1177588.
GenomeReviews	Gene locus VV1_0639 in contig AE016795_GR.
KEGG	vvu:VV1_0639.
PATRIC	20158100. VBIVibVul94426_0620.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG568825.
OMA	FANTAVD.
ProtClustDB	PRK02318.
Enzyme and pathway databases
BioCyc	VVUL216895:VV1_0639-MONOMER.
Family and domain databases
HAMAP	MF_00196. Mannitol_dehydrog. [Tree]
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR013328. DH_multihelical. IPR023028. Mannitol_1_phos_5_DH. IPR000669. Mannitol_DH. IPR013118. Mannitol_DH_C. IPR023027. Mannitol_DH_CS. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KO	K00009.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
PROSITE	PS00974. MANNITOL_DHGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_VIBVU

Accession

Primary (citable) accession number: Q8DEF5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 23, 2003
Last sequence update:	March 1, 2003
Last modified:	January 25, 2012
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program