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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Vibrio vulnificus (strain CMCP6)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Nucleophile; for GATase activityUniRule annotation1
Active sitei605For Fru-6P isomerization activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase

Enzyme and pathway databases

BioCyciVVUL216895:G1GJ4-626-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:VV1_0641
OrganismiVibrio vulnificus (strain CMCP6)
Taxonomic identifieri216895 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation
ChainiPRO_00001354112 – 610Glutamine--fructose-6-phosphate aminotransferase [isomerizing]Add BLAST609

Proteomic databases

PRIDEiQ8DEF3

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ8DEF3
SMRiQ8DEF3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 218Glutamine amidotransferase type-2UniRule annotationAdd BLAST217
Domaini286 – 426SIS 1UniRule annotationAdd BLAST141
Domaini459 – 600SIS 2UniRule annotationAdd BLAST142

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiENOG4105C46 Bacteria
COG0449 LUCA
HOGENOMiHOG000258896
KOiK00820
OMAiASEYRYA
OrthoDBiPOG091H0061

Family and domain databases

CDDicd05008 SIS_GlmS_GlmD_1, 1 hit
cd05009 SIS_GlmS_GlmD_2, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00164 GlmS, 1 hit
InterProiView protein in InterPro
IPR017932 GATase_2_dom
IPR035466 GlmS/AgaS_SIS
IPR035490 GlmS/FrlB_SIS
IPR005855 GlmS_trans
IPR029055 Ntn_hydrolases_N
IPR001347 SIS
PANTHERiPTHR10937:SF0 PTHR10937:SF0, 1 hit
PfamiView protein in Pfam
PF01380 SIS, 2 hits
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR01135 glmS, 1 hit
PROSITEiView protein in PROSITE
PS51278 GATASE_TYPE_2, 1 hit
PS51464 SIS, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8DEF3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGIVGAVAQ RDVAEILVEG LRRLEYRGYD SAGVAVVDSQ SNLTRIRRLG
60 70 80 90 100
KVQELADAVD QAEVVGGTGI AHTRWATHGE PSEINAHPHQ SGDISVVHNG
110 120 130 140 150
IIENHETLRE LLQSRGYVFE SQTDTEVIAH LVEWELRTAA SLLEAVQKTV
160 170 180 190 200
KQLEGAYGTV VLDRNDPSRI VVARSGSPIV IGFGVGENFL ASDQLALLNV
210 220 230 240 250
TRRFMYLEEG DVAEITRREV AVYDASGERV EREIAESNAE HDAGDKGQYR
260 270 280 290 300
HFMQKEIYEQ PTALINTMEG RITADSVVTE AIGVNAAEIL SKVEHVQIVA
310 320 330 340 350
CGTSYNAGMT ARYWFEDIAG VSCDVEIASE FRYRKFVTRP NSLLITLSQS
360 370 380 390 400
GETADTLAAL RLAKEKGYMA AMTICNVAGS SLVRESDFAF MTRAGVEIGV
410 420 430 440 450
ASTKAFTTQL AALLMLVTAL GKQQGRISKE KEKEIVEALH ALPKQINAAL
460 470 480 490 500
SFEKDIEALA TDFADKHHTL FLGRGEFYPI AMEASLKLKE ISYIHAEAYA
510 520 530 540 550
AGELKHGPLA LIDADMPVVV VAPSNDLLEK LKSNVEEVRA RGGLLYVFAD
560 570 580 590 600
ADAGFEGDET MKIITMPHVS EITAAIYYTI PMQLLSYYVA LIKGTDVDQP
610
RNLAKAVTVE
Length:610
Mass (Da):66,636
Last modified:January 23, 2007 - v3
Checksum:iE5F18FF5A533C1EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016795 Genomic DNA Translation: AAO09154.1
RefSeqiWP_011078721.1, NC_004459.3

Genome annotation databases

EnsemblBacteriaiAAO09154; AAO09154; VV1_0641
KEGGivvu:VV1_0641

Entry informationi

Entry nameiGLMS_VIBVU
AccessioniPrimary (citable) accession number: Q8DEF3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2003
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 100 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

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