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Q8DED3

- PDXA_VIBVU

UniProt

Q8DED3 - PDXA_VIBVU

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Protein

4-hydroxythreonine-4-phosphate dehydrogenase

Gene
pdxA, VV1_0662
Organism
Vibrio vulnificus (strain CMCP6)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) By similarity.UniRule annotation

Catalytic activityi

4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH.UniRule annotation

Cofactori

Binds 1 divalent metal cation per subunit. Can use ions such as zinc, magnesium or cobalt By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei134 – 1341Substrate By similarity
Binding sitei135 – 1351Substrate By similarity
Metal bindingi164 – 1641Divalent metal cation; shared with dimeric partner By similarity
Metal bindingi209 – 2091Divalent metal cation; shared with dimeric partner By similarity
Metal bindingi265 – 2651Divalent metal cation; shared with dimeric partner By similarity
Binding sitei273 – 2731Substrate By similarity
Binding sitei282 – 2821Substrate By similarity
Binding sitei291 – 2911Substrate By similarity

GO - Molecular functioni

  1. 4-hydroxythreonine-4-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
  2. cobalt ion binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. NAD binding Source: InterPro
  5. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. pyridoxal phosphate biosynthetic process Source: UniProtKB-HAMAP
  2. pyridoxine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyridoxine biosynthesis

Keywords - Ligandi

Cobalt, Magnesium, Metal-binding, NAD, NADP, Zinc

Enzyme and pathway databases

BioCyciVVUL216895:GIYM-615-MONOMER.
UniPathwayiUPA00244; UER00312.

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxythreonine-4-phosphate dehydrogenase (EC:1.1.1.262)
Alternative name(s):
4-(phosphohydroxy)-L-threonine dehydrogenase
Gene namesi
Name:pdxA
Ordered Locus Names:VV1_0662
OrganismiVibrio vulnificus (strain CMCP6)
Taxonomic identifieri216895 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000002275: Chromosome 1

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3283284-hydroxythreonine-4-phosphate dehydrogenaseUniRule annotationPRO_0000188835Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi216895.VV1_0662.

Structurei

3D structure databases

ProteinModelPortaliQ8DED3.
SMRiQ8DED3. Positions 3-328.

Family & Domainsi

Sequence similaritiesi

Belongs to the PdxA family.

Phylogenomic databases

eggNOGiCOG1995.
HOGENOMiHOG000221592.
KOiK00097.
OMAiDTLFQDK.
OrthoDBiEOG6GN6ZC.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
HAMAPiMF_00536. PdxA.
InterProiIPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view]
PfamiPF04166. PdxA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00557. pdxA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8DED3-1 [UniParc]FASTAAdd to Basket

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MVKRLVVTAG EPAGIGPDLV LALSKEHWPH QLVVCADKKM LAQRAEQLGI    50
NVTLLDYDAS TAPSPQQAGT LVVEHIDMPS TCVAGQLNEE NGHYVLKTLE 100
RAALGCMKSE FDAIVTGPVH KGVINRAGVA FSGHTEFFAE LSNTPLVVMM 150
LATEGLRVAL VTTHIPLAYV SKAVTAERLL KIIDILHRDL VEKFAIAEPK 200
IYVCGLNPHA GEDGCLGREE IETITPTLEK IRQEKGIHLL GPLPADTIFN 250
EKYLNDADAV LGMYHDQVLP VLKYKGFGQS VNITLGLPFI RTSVDHGTAL 300
DLAGTGQADT GSFRTALQHA IELVEKKQ 328
Length:328
Mass (Da):35,492
Last modified:March 1, 2003 - v1
Checksum:i05BC20D5561C9211
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016795 Genomic DNA. Translation: AAO09174.1.
RefSeqiNP_759647.1. NC_004459.3.

Genome annotation databases

EnsemblBacteriaiAAO09174; AAO09174; VV1_0662.
GeneIDi1177610.
KEGGivvu:VV1_0662.
PATRICi20158146. VBIVibVul94426_0643.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016795 Genomic DNA. Translation: AAO09174.1 .
RefSeqi NP_759647.1. NC_004459.3.

3D structure databases

ProteinModelPortali Q8DED3.
SMRi Q8DED3. Positions 3-328.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 216895.VV1_0662.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO09174 ; AAO09174 ; VV1_0662 .
GeneIDi 1177610.
KEGGi vvu:VV1_0662.
PATRICi 20158146. VBIVibVul94426_0643.

Phylogenomic databases

eggNOGi COG1995.
HOGENOMi HOG000221592.
KOi K00097.
OMAi DTLFQDK.
OrthoDBi EOG6GN6ZC.

Enzyme and pathway databases

UniPathwayi UPA00244 ; UER00312 .
BioCyci VVUL216895:GIYM-615-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
HAMAPi MF_00536. PdxA.
InterProi IPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view ]
Pfami PF04166. PdxA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00557. pdxA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Vibrio vulnificus CMCP6."
    Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E.
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CMCP6.

Entry informationi

Entry nameiPDXA_VIBVU
AccessioniPrimary (citable) accession number: Q8DED3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2003
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The active site is located at the dimer interface By similarity.

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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