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Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene

gppA

Organism
Vibrio vulnificus (strain CMCP6)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.UniRule annotation

Catalytic activityi

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

Pathwayi: ppGpp biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes ppGpp from GTP.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (gppA)
This subpathway is part of the pathway ppGpp biosynthesis, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes ppGpp from GTP, the pathway ppGpp biosynthesis and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

UniPathwayiUPA00908; UER00885

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation (EC:3.6.1.40UniRule annotation)
Alternative name(s):
Guanosine pentaphosphate phosphohydrolaseUniRule annotation
pppGpp-5'-phosphohydrolaseUniRule annotation
Gene namesi
Name:gppAUniRule annotation
Ordered Locus Names:VV1_0940
OrganismiVibrio vulnificus (strain CMCP6)
Taxonomic identifieri216895 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001942951 – 497Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseAdd BLAST497

Proteomic databases

PRIDEiQ8DDN5

Structurei

3D structure databases

ProteinModelPortaliQ8DDN5
SMRiQ8DDN5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GppA/Ppx family. GppA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C9X Bacteria
COG0248 LUCA
HOGENOMiHOG000258672
KOiK01524
OMAiWQICVGA
OrthoDBiPOG091H00D6

Family and domain databases

HAMAPiMF_01550 GppA, 1 hit
InterProiView protein in InterPro
IPR023709 Guo-5TP_3DP_PyrP
IPR003695 Ppx_GppA
IPR030673 PyroPPase_GppA_Ppx
PfamiView protein in Pfam
PF02541 Ppx-GppA, 1 hit
PIRSFiPIRSF001267 Pyrophosphatase_GppA_Ppx, 1 hit

Sequencei

Sequence statusi: Complete.

Q8DDN5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQAGNSPLY AAIDLGSNSF HMLVVRHIDG SVQTMAKIKR KVRLAAGLDE
60 70 80 90 100
HNALSKEAMQ RGWDCLSLFA ERLQDIPAEH IRIVGTATLR TATNVDLFLQ
110 120 130 140 150
KANQILGHPI EVISGEEEAA TIYKGVAHTS GGSGRRLVVD IGGASTELII
160 170 180 190 200
GEGFEAKALT SLKMGCVTWL ENFFKDRQLS ARNFEAAIEG AKQTLLPILE
210 220 230 240 250
QYKSLGWDVC VGASGTVQAL QEIMLAQGMD EVITHAKLKR LQKQAMLADH
260 270 280 290 300
LEELEIEGLT LERALVFPSG LSILIAIFEL LEIDAMTLAG GALREGLAYE
310 320 330 340 350
MMSELRQDDI RARTIGSIQS RYQLDSQYGQ QVANLALKLL QQVGDVMWIP
360 370 380 390 400
EPQGAMLLET TAKLHEIGLT IDFKKGGEHS AYLMQHLDLP GFTRAQKFLM
410 420 430 440 450
GEIARRYREG LTSLPEQHAL SGNSGKRLLR LLRLAVILSH RRQPSLEPEV
460 470 480 490
TLSAEGDKLT LAIDAQWLEN NPLTAAELEL EANRQTDIGW PLVIESR
Length:497
Mass (Da):54,755
Last modified:March 1, 2003 - v1
Checksum:iA4EB735219F4792C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016795 Genomic DNA Translation: AAO09437.1
RefSeqiWP_011078989.1, NC_004459.3

Genome annotation databases

EnsemblBacteriaiAAO09437; AAO09437; VV1_0940
GeneIDi2626055
KEGGivvu:VV1_0940

Similar proteinsi

Entry informationi

Entry nameiGPPA_VIBVU
AccessioniPrimary (citable) accession number: Q8DDN5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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