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Q8DDD8

- PURK_VIBVU

UniProt

Q8DDD8 - PURK_VIBVU

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Protein
N5-carboxyaminoimidazole ribonucleotide synthase
Gene
purK, VV1_1053
Organism
Vibrio vulnificus (strain CMCP6)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO3- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) By similarity.

Catalytic activityi

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO3- = ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei93 – 931ATP By similarity
Binding sitei133 – 1331ATP By similarity
Binding sitei144 – 1441ATP By similarity
Binding sitei183 – 1831ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi175 – 1784ATP By similarity
Nucleotide bindingi257 – 2582ATP By similarity

GO - Molecular functioni

  1. 5-(carboxyamino)imidazole ribonucleotide synthase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW
  3. metal ion binding Source: InterPro
  4. phosphoribosylaminoimidazole carboxylase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciVVUL216895:GIYM-966-MONOMER.
UniPathwayiUPA00074; UER00942.

Names & Taxonomyi

Protein namesi
Recommended name:
N5-carboxyaminoimidazole ribonucleotide synthase (EC:6.3.4.18)
Short name:
N5-CAIR synthase
Alternative name(s):
5-(carboxyamino)imidazole ribonucleotide synthetase
Gene namesi
Name:purK
Ordered Locus Names:VV1_1053
OrganismiVibrio vulnificus (strain CMCP6)
Taxonomic identifieri216895 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000002275: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 377377N5-carboxyaminoimidazole ribonucleotide synthase
PRO_0000075018Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi216895.VV1_1053.

Structurei

3D structure databases

ProteinModelPortaliQ8DDD8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini97 – 287191ATP-grasp
Add
BLAST

Sequence similaritiesi

Belongs to the PurK/PurT family.
Contains 1 ATP-grasp domain.

Phylogenomic databases

eggNOGiCOG0026.
HOGENOMiHOG000034026.
KOiK01589.
OMAiALQTWMP.
OrthoDBiEOG6QZMX7.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProiIPR005875. AIR_COase_ATPase-su.
IPR011761. ATP-grasp.
IPR003135. ATP-grasp_carboxylate-amine.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamiPF02222. ATP-grasp. 1 hit.
[Graphical view]
SUPFAMiSSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01161. purK. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8DDD8-1 [UniParc]FASTAAdd to Basket

« Hide

MHVLVLGAGQ LARMMSLAGA PLNIQISAYD VTTGDVVHPL TLHLLGHGLE    50
QAIEYVDVIT AEFEHIPHDV LAICQASGKF LPSSEAIKAG GDRRLEKALL 100
DHAGVRNANY YVIETREDFN KAIEHVGIPM VLKSALGGYD GKGQWRLKDA 150
AQIETLWQEM AACIAATPTQ AIVAEEFVPF QREVSLIGAR GKEGQIEVYP 200
LAENIHVNGV LSLSTAIDSP DLQEQAKHMF TAVAETLNYV GVLALEFFDV 250
DGQLLVNEIA PRVHNSGHWT QQGAETCQFE NHLRAVCGLP LGSTKLVRET 300
SMINILGEDT LPASVMAMDG CHIHWYGKEK RAGRKMGHIN VCGDYSGELQ 350
RRLCALANVL DEKAFPAVHE FAKKWQA 377
Length:377
Mass (Da):41,231
Last modified:March 1, 2003 - v1
Checksum:i6533CC9932BA21C0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016795 Genomic DNA. Translation: AAO09540.1.
RefSeqiNP_760013.1. NC_004459.3.

Genome annotation databases

EnsemblBacteriaiAAO09540; AAO09540; VV1_1053.
GeneIDi1177986.
KEGGivvu:VV1_1053.
PATRICi20158919. VBIVibVul94426_1010.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016795 Genomic DNA. Translation: AAO09540.1 .
RefSeqi NP_760013.1. NC_004459.3.

3D structure databases

ProteinModelPortali Q8DDD8.
ModBasei Search...

Protein-protein interaction databases

STRINGi 216895.VV1_1053.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO09540 ; AAO09540 ; VV1_1053 .
GeneIDi 1177986.
KEGGi vvu:VV1_1053.
PATRICi 20158919. VBIVibVul94426_1010.

Phylogenomic databases

eggNOGi COG0026.
HOGENOMi HOG000034026.
KOi K01589.
OMAi ALQTWMP.
OrthoDBi EOG6QZMX7.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00942 .
BioCyci VVUL216895:GIYM-966-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProi IPR005875. AIR_COase_ATPase-su.
IPR011761. ATP-grasp.
IPR003135. ATP-grasp_carboxylate-amine.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
[Graphical view ]
Pfami PF02222. ATP-grasp. 1 hit.
[Graphical view ]
SUPFAMi SSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsi TIGR01161. purK. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Vibrio vulnificus CMCP6."
    Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E.
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CMCP6.

Entry informationi

Entry nameiPURK_VIBVU
AccessioniPrimary (citable) accession number: Q8DDD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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