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Q8DDD8 (PURK_VIBVU) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
N5-carboxyaminoimidazole ribonucleotide synthase

Short name=N5-CAIR synthase
EC=6.3.4.18
Alternative name(s):
5-(carboxyamino)imidazole ribonucleotide synthetase
Gene names
Name:purK
Ordered Locus Names:VV1_1053
OrganismVibrio vulnificus (strain CMCP6) [Complete proteome] [HAMAP]
Taxonomic identifier216895 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length377 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO3- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) By similarity.

Catalytic activity

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO3- = ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole.

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the PurK/PurT family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 377377N5-carboxyaminoimidazole ribonucleotide synthase
PRO_0000075018

Regions

Domain97 – 287191ATP-grasp
Nucleotide binding175 – 1784ATP By similarity
Nucleotide binding257 – 2582ATP By similarity

Sites

Binding site931ATP By similarity
Binding site1331ATP By similarity
Binding site1441ATP By similarity
Binding site1831ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8DDD8 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 6533CC9932BA21C0

FASTA37741,231
        10         20         30         40         50         60 
MHVLVLGAGQ LARMMSLAGA PLNIQISAYD VTTGDVVHPL TLHLLGHGLE QAIEYVDVIT 

        70         80         90        100        110        120 
AEFEHIPHDV LAICQASGKF LPSSEAIKAG GDRRLEKALL DHAGVRNANY YVIETREDFN 

       130        140        150        160        170        180 
KAIEHVGIPM VLKSALGGYD GKGQWRLKDA AQIETLWQEM AACIAATPTQ AIVAEEFVPF 

       190        200        210        220        230        240 
QREVSLIGAR GKEGQIEVYP LAENIHVNGV LSLSTAIDSP DLQEQAKHMF TAVAETLNYV 

       250        260        270        280        290        300 
GVLALEFFDV DGQLLVNEIA PRVHNSGHWT QQGAETCQFE NHLRAVCGLP LGSTKLVRET 

       310        320        330        340        350        360 
SMINILGEDT LPASVMAMDG CHIHWYGKEK RAGRKMGHIN VCGDYSGELQ RRLCALANVL 

       370 
DEKAFPAVHE FAKKWQA 

« Hide

References

[1]"Complete genome sequence of Vibrio vulnificus CMCP6."
Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E.
Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CMCP6.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016795 Genomic DNA. Translation: AAO09540.1.
RefSeqNP_760013.1. NC_004459.3.

3D structure databases

ProteinModelPortalQ8DDD8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING216895.VV1_1053.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO09540; AAO09540; VV1_1053.
GeneID1177986.
KEGGvvu:VV1_1053.
PATRIC20158919. VBIVibVul94426_1010.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0026.
HOGENOMHOG000034026.
KOK01589.
OMAHWYEKEV.
OrthoDBEOG6QZMX7.
ProtClustDBPRK06019.

Enzyme and pathway databases

BioCycVVUL216895:GIYM-966-MONOMER.
UniPathwayUPA00074; UER00942.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProIPR005875. AIR_COase_ATPase-su.
IPR011761. ATP-grasp.
IPR003135. ATP-grasp_carboxylate-amine.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamPF02222. ATP-grasp. 1 hit.
[Graphical view]
SUPFAMSSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01161. purK. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePURK_VIBVU
AccessionPrimary (citable) accession number: Q8DDD8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: March 1, 2003
Last modified: November 13, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways