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Q8DDD8

- PURK_VIBVU

UniProt

Q8DDD8 - PURK_VIBVU

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Protein

N5-carboxyaminoimidazole ribonucleotide synthase

Gene

purK

Organism
Vibrio vulnificus (strain CMCP6)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO3- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).UniRule annotation

Catalytic activityi

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO3- = ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei93 – 931ATPUniRule annotation
Binding sitei133 – 1331ATPUniRule annotation
Binding sitei183 – 1831ATPUniRule annotation
Binding sitei206 – 2061ATPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi138 – 1447ATPUniRule annotation
Nucleotide bindingi175 – 1784ATPUniRule annotation
Nucleotide bindingi257 – 2582ATPUniRule annotation

GO - Molecular functioni

  1. 5-(carboxyamino)imidazole ribonucleotide synthase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW
  3. metal ion binding Source: InterPro
  4. phosphoribosylaminoimidazole carboxylase activity Source: InterPro

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciVVUL216895:GIYM-966-MONOMER.
UniPathwayiUPA00074; UER00942.

Names & Taxonomyi

Protein namesi
Recommended name:
N5-carboxyaminoimidazole ribonucleotide synthaseUniRule annotation (EC:6.3.4.18UniRule annotation)
Short name:
N5-CAIR synthaseUniRule annotation
Alternative name(s):
5-(carboxyamino)imidazole ribonucleotide synthetaseUniRule annotation
Gene namesi
Name:purKUniRule annotation
Ordered Locus Names:VV1_1053
OrganismiVibrio vulnificus (strain CMCP6)
Taxonomic identifieri216895 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000002275: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 377377N5-carboxyaminoimidazole ribonucleotide synthasePRO_0000075018Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi216895.VV1_1053.

Structurei

3D structure databases

ProteinModelPortaliQ8DDD8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini97 – 287191ATP-graspUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the PurK/PurT family.UniRule annotation
Contains 1 ATP-grasp domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0026.
HOGENOMiHOG000034026.
KOiK01589.
OMAiALQTWMP.
OrthoDBiEOG6QZMX7.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPiMF_01928. PurK.
InterProiIPR005875. AIR_COase_ATPase-su.
IPR011761. ATP-grasp.
IPR003135. ATP-grasp_carboxylate-amine.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamiPF02222. ATP-grasp. 1 hit.
[Graphical view]
SUPFAMiSSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01161. purK. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8DDD8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHVLVLGAGQ LARMMSLAGA PLNIQISAYD VTTGDVVHPL TLHLLGHGLE
60 70 80 90 100
QAIEYVDVIT AEFEHIPHDV LAICQASGKF LPSSEAIKAG GDRRLEKALL
110 120 130 140 150
DHAGVRNANY YVIETREDFN KAIEHVGIPM VLKSALGGYD GKGQWRLKDA
160 170 180 190 200
AQIETLWQEM AACIAATPTQ AIVAEEFVPF QREVSLIGAR GKEGQIEVYP
210 220 230 240 250
LAENIHVNGV LSLSTAIDSP DLQEQAKHMF TAVAETLNYV GVLALEFFDV
260 270 280 290 300
DGQLLVNEIA PRVHNSGHWT QQGAETCQFE NHLRAVCGLP LGSTKLVRET
310 320 330 340 350
SMINILGEDT LPASVMAMDG CHIHWYGKEK RAGRKMGHIN VCGDYSGELQ
360 370
RRLCALANVL DEKAFPAVHE FAKKWQA
Length:377
Mass (Da):41,231
Last modified:March 1, 2003 - v1
Checksum:i6533CC9932BA21C0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016795 Genomic DNA. Translation: AAO09540.1.
RefSeqiNP_760013.1. NC_004459.3.

Genome annotation databases

EnsemblBacteriaiAAO09540; AAO09540; VV1_1053.
GeneIDi1177986.
KEGGivvu:VV1_1053.
PATRICi20158919. VBIVibVul94426_1010.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016795 Genomic DNA. Translation: AAO09540.1 .
RefSeqi NP_760013.1. NC_004459.3.

3D structure databases

ProteinModelPortali Q8DDD8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 216895.VV1_1053.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO09540 ; AAO09540 ; VV1_1053 .
GeneIDi 1177986.
KEGGi vvu:VV1_1053.
PATRICi 20158919. VBIVibVul94426_1010.

Phylogenomic databases

eggNOGi COG0026.
HOGENOMi HOG000034026.
KOi K01589.
OMAi ALQTWMP.
OrthoDBi EOG6QZMX7.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00942 .
BioCyci VVUL216895:GIYM-966-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPi MF_01928. PurK.
InterProi IPR005875. AIR_COase_ATPase-su.
IPR011761. ATP-grasp.
IPR003135. ATP-grasp_carboxylate-amine.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
[Graphical view ]
Pfami PF02222. ATP-grasp. 1 hit.
[Graphical view ]
SUPFAMi SSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsi TIGR01161. purK. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Vibrio vulnificus CMCP6."
    Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E.
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CMCP6.

Entry informationi

Entry nameiPURK_VIBVU
AccessioniPrimary (citable) accession number: Q8DDD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3