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Q8DDD8

- PURK_VIBVU

UniProt

Q8DDD8 - PURK_VIBVU

Protein

N5-carboxyaminoimidazole ribonucleotide synthase

Gene

purK

Organism
Vibrio vulnificus (strain CMCP6)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO3- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).By similarity

    Catalytic activityi

    ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO3- = ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei93 – 931ATPBy similarity
    Binding sitei133 – 1331ATPBy similarity
    Binding sitei144 – 1441ATPBy similarity
    Binding sitei183 – 1831ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi175 – 1784ATPPROSITE-ProRule annotation
    Nucleotide bindingi257 – 2582ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. 5-(carboxyamino)imidazole ribonucleotide synthase activity Source: UniProtKB-EC
    2. ATP binding Source: UniProtKB-KW
    3. metal ion binding Source: InterPro
    4. phosphoribosylaminoimidazole carboxylase activity Source: InterPro

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciVVUL216895:GIYM-966-MONOMER.
    UniPathwayiUPA00074; UER00942.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N5-carboxyaminoimidazole ribonucleotide synthase (EC:6.3.4.18)
    Short name:
    N5-CAIR synthase
    Alternative name(s):
    5-(carboxyamino)imidazole ribonucleotide synthetase
    Gene namesi
    Name:purK
    Ordered Locus Names:VV1_1053
    OrganismiVibrio vulnificus (strain CMCP6)
    Taxonomic identifieri216895 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000002275: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 377377N5-carboxyaminoimidazole ribonucleotide synthasePRO_0000075018Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi216895.VV1_1053.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8DDD8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini97 – 287191ATP-graspPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PurK/PurT family.Curated
    Contains 1 ATP-grasp domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0026.
    HOGENOMiHOG000034026.
    KOiK01589.
    OMAiALQTWMP.
    OrthoDBiEOG6QZMX7.

    Family and domain databases

    Gene3Di3.30.1490.20. 1 hit.
    3.30.470.20. 1 hit.
    3.40.50.20. 1 hit.
    InterProiIPR005875. AIR_COase_ATPase-su.
    IPR011761. ATP-grasp.
    IPR003135. ATP-grasp_carboxylate-amine.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR016185. PreATP-grasp_dom.
    IPR011054. Rudment_hybrid_motif.
    [Graphical view]
    PfamiPF02222. ATP-grasp. 1 hit.
    [Graphical view]
    SUPFAMiSSF51246. SSF51246. 1 hit.
    SSF52440. SSF52440. 1 hit.
    TIGRFAMsiTIGR01161. purK. 1 hit.
    PROSITEiPS50975. ATP_GRASP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8DDD8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHVLVLGAGQ LARMMSLAGA PLNIQISAYD VTTGDVVHPL TLHLLGHGLE    50
    QAIEYVDVIT AEFEHIPHDV LAICQASGKF LPSSEAIKAG GDRRLEKALL 100
    DHAGVRNANY YVIETREDFN KAIEHVGIPM VLKSALGGYD GKGQWRLKDA 150
    AQIETLWQEM AACIAATPTQ AIVAEEFVPF QREVSLIGAR GKEGQIEVYP 200
    LAENIHVNGV LSLSTAIDSP DLQEQAKHMF TAVAETLNYV GVLALEFFDV 250
    DGQLLVNEIA PRVHNSGHWT QQGAETCQFE NHLRAVCGLP LGSTKLVRET 300
    SMINILGEDT LPASVMAMDG CHIHWYGKEK RAGRKMGHIN VCGDYSGELQ 350
    RRLCALANVL DEKAFPAVHE FAKKWQA 377
    Length:377
    Mass (Da):41,231
    Last modified:March 1, 2003 - v1
    Checksum:i6533CC9932BA21C0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016795 Genomic DNA. Translation: AAO09540.1.
    RefSeqiNP_760013.1. NC_004459.3.

    Genome annotation databases

    EnsemblBacteriaiAAO09540; AAO09540; VV1_1053.
    GeneIDi1177986.
    KEGGivvu:VV1_1053.
    PATRICi20158919. VBIVibVul94426_1010.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016795 Genomic DNA. Translation: AAO09540.1 .
    RefSeqi NP_760013.1. NC_004459.3.

    3D structure databases

    ProteinModelPortali Q8DDD8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 216895.VV1_1053.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO09540 ; AAO09540 ; VV1_1053 .
    GeneIDi 1177986.
    KEGGi vvu:VV1_1053.
    PATRICi 20158919. VBIVibVul94426_1010.

    Phylogenomic databases

    eggNOGi COG0026.
    HOGENOMi HOG000034026.
    KOi K01589.
    OMAi ALQTWMP.
    OrthoDBi EOG6QZMX7.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00942 .
    BioCyci VVUL216895:GIYM-966-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1490.20. 1 hit.
    3.30.470.20. 1 hit.
    3.40.50.20. 1 hit.
    InterProi IPR005875. AIR_COase_ATPase-su.
    IPR011761. ATP-grasp.
    IPR003135. ATP-grasp_carboxylate-amine.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR016185. PreATP-grasp_dom.
    IPR011054. Rudment_hybrid_motif.
    [Graphical view ]
    Pfami PF02222. ATP-grasp. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51246. SSF51246. 1 hit.
    SSF52440. SSF52440. 1 hit.
    TIGRFAMsi TIGR01161. purK. 1 hit.
    PROSITEi PS50975. ATP_GRASP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Vibrio vulnificus CMCP6."
      Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E.
      Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CMCP6.

    Entry informationi

    Entry nameiPURK_VIBVU
    AccessioniPrimary (citable) accession number: Q8DDD8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2005
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3