Reviewed, UniProtKB/Swiss-Prot Q8DDD7 (PUR6_VIBVU)

Names and origin

Protein names

Recommended name:
    Phosphoribosylaminoimidazole carboxylase catalytic subunit
    EC=4.1.1.21
Alternative name(s):
    AIR carboxylase
      Short name=AIRC

Gene names

Name:	purE
Ordered Locus Names:	VV1_1054

Organism

Vibrio vulnificus [Complete proteome] [HAMAP]

Taxonomic identifier

672 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length	161 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	This subunit can alone transform AIR to CAIR, but in association with purK, which possesses an ATPase activity, an enzyme complex is produced which is capable of converting AIR to CAIR efficiently under physiological condition By similarity.
Catalytic activity	5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2.
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.
Subunit structure	Homooctamer By similarity.
Sequence similarities	Belongs to the AIR carboxylase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	phosphoribosylaminoimidazole carboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 161	161	Phosphoribosylaminoimidazole carboxylase catalytic subunit		PRO_0000074984
Sites
	Binding site	9	1	Substrate By similarity
	Binding site	12	1	Substrate By similarity
	Binding site	39	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8DDD7-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 17C09D4D44350A01	FASTA	161	16,696
	10 20 30 40 50 60 MKVGIIMGSK SDWPTMKLAA EMLDRFGVEY ETKVVSAHRT PHLLAEYAST AKERGLKVII 70 80 90 100 110 120 AGAGGAAHLP GMAAAFTSLP VLGVPVQSRA LSGLDSLYSI VQMPKGIAVG TLAIGEAGAA 130 140 150 160 NAGLLAAQIL GTHDENIMAK VEAFRSEQTE SVLANPNPAE D

References

[1]	"Complete genome sequence of Vibrio vulnificus CMCP6." Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E. Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CMCP6.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE016795 Genomic DNA. Translation: AAO09541.1.
RefSeq	NP_760014.1.
3D structure databases
HSSP	HSSP built from PDB template 1QCZ based on UniProtKB P09028.
ModBase	Search...
Genome annotation databases
GeneID	1177987.
GenomeReviews	Gene locus VV1_1054 in contig AE016795_GR.
KEGG	vvu:VV1_1054.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8DDD7.
OMA	GVVMGSS.
Enzyme and pathway databases
BioCyc	VVUL216895:VV1_1054-MON.
BRENDA	4.1.1.21. 277169.
Family and domain databases
InterPro	IPR000031. AIR_COase_core. [Graphical view]
Gene3D	G3DSA:3.40.50.7700. AIR_carboxyl. 1 hit.
PANTHER	PTHR23046. AIR_carboxyl. 1 hit.
Pfam	PF00731. AIRC. 1 hit. [Graphical view]
ProDom	PD002193. AIR_carboxyl. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01162. purE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PUR6_VIBVU

Accession

Primary (citable) accession number: Q8DDD7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2005
Last sequence update:	March 1, 2003
Last modified:	November 3, 2009
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)