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Protein

Glycerol-3-phosphate acyltransferase

Gene

plsB

Organism
Vibrio vulnificus (strain CMCP6)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate.UniRule annotation

Pathwayi: CDP-diacylglycerol biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glycerol-3-phosphate acyltransferase (plsB)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyciVVUL216895:GIYM-1055-MONOMER.
UniPathwayiUPA00557; UER00612.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate acyltransferaseUniRule annotation (EC:2.3.1.15UniRule annotation)
Short name:
GPATUniRule annotation
Gene namesi
Name:plsBUniRule annotation
Ordered Locus Names:VV1_1165
OrganismiVibrio vulnificus (strain CMCP6)
Taxonomic identifieri216895 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 809809Glycerol-3-phosphate acyltransferasePRO_0000195237Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi216895.VV1_1165.

Structurei

3D structure databases

ProteinModelPortaliQ8DD48.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi306 – 3116HXXXXD motif

Domaini

The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.UniRule annotation

Sequence similaritiesi

Belongs to the GPAT/DAPAT family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E55. Bacteria.
COG2937. LUCA.
HOGENOMiHOG000218231.
KOiK00631.
OMAiEVIYVPC.
OrthoDBiEOG6B625B.

Family and domain databases

HAMAPiMF_00393. Glyc3P_acyltrans.
InterProiIPR022284. GPAT/DHAPAT.
IPR028354. GPAT_PlsB.
IPR002123. Plipid/glycerol_acylTrfase.
[Graphical view]
PANTHERiPTHR12563. PTHR12563. 2 hits.
PfamiPF01553. Acyltransferase. 1 hit.
[Graphical view]
PIRSFiPIRSF500064. GPAT. 1 hit.
PIRSF000437. GPAT_DHAPAT. 1 hit.
SMARTiSM00563. PlsC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03703. plsB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8DD48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSGQSFSHS LLKLPLSALV KGTAIPSNPI DDHHIDINKP IVYALPFRSA
60 70 80 90 100
VDLLTLQKHA LELGLPDPLS PLEIHGKSLK RYVFIASRPT LVQSDNDVPS
110 120 130 140 150
DSIALFSDLL ALHAEDSELD VQVIPATVLW GRKPGKEGNN KPYLQAMNGL
160 170 180 190 200
QKAKAVITAG RDCLVRFSPV VSLRYMAQSH GTDSSIAHKL ARVARIHFSR
210 220 230 240 250
QKLAASGPDL PSRQVLFARL MKSPAIEQAI EEEAKNKNIS MEKARKEAQD
260 270 280 290 300
IMDEIAADFS YSLVKQGDRL LGWLWNKLYQ GLNINNAATV RRLAQDGHEI
310 320 330 340 350
VYVPCHRSHM DYLLLSYVLY HEGMVPPHIA AGINLNFFPA GPIFRRGGAF
360 370 380 390 400
FIRRSFKGNR LYSTIFREYL AELFAKGYSV EYFSEGGRSR TGRLLPAKTG
410 420 430 440 450
MLAMTIQAML RGLNRPVTLV PVYIGYEHVM EVATYAKELR GKRKEKENAG
460 470 480 490 500
LVLRTLRKLR NFGLGYVNFG EPIPLNQYLN EHAPEWTKDI DPMGASRPQW
510 520 530 540 550
INPVVNQLAN KMMTHINDAA AANALTLCAT ALLASRQRAL SKDSLIHQIE
560 570 580 590 600
CYLQLLKNVP YSKTYTVPSE SAEALVEHAI SLDKFVIETD TMGDIISLDR
610 620 630 640 650
NQSILMTYYR NNIIHLFALP SLIAQMIIRQ ENLTVSQIQQ QVAEIYPFLK
660 670 680 690 700
AELFLSHKEE ELDELVVKVL NELVSQDLIS LKEDKVAKNQ ANTLTLVLLG
710 720 730 740 750
RTISETLQRY SIAFNLLVSN PELAKADLEQ KSQDIAQRLT RLHGINAPEY
760 770 780 790 800
FDKGVFASLF STLKQQGYLD SDGNCDGEKT AQFATLLYAL LYPEVKLTIE

ESVFQLKSA
Length:809
Mass (Da):90,596
Last modified:March 1, 2003 - v1
Checksum:i0E04FF0B4980DCDC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016795 Genomic DNA. Translation: AAO09636.1.
RefSeqiWP_011079175.1. NC_004459.3.

Genome annotation databases

EnsemblBacteriaiAAO09636; AAO09636; VV1_1165.
KEGGivvu:VV1_1165.
PATRICi20159135. VBIVibVul94426_1106.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016795 Genomic DNA. Translation: AAO09636.1.
RefSeqiWP_011079175.1. NC_004459.3.

3D structure databases

ProteinModelPortaliQ8DD48.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi216895.VV1_1165.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO09636; AAO09636; VV1_1165.
KEGGivvu:VV1_1165.
PATRICi20159135. VBIVibVul94426_1106.

Phylogenomic databases

eggNOGiENOG4105E55. Bacteria.
COG2937. LUCA.
HOGENOMiHOG000218231.
KOiK00631.
OMAiEVIYVPC.
OrthoDBiEOG6B625B.

Enzyme and pathway databases

UniPathwayiUPA00557; UER00612.
BioCyciVVUL216895:GIYM-1055-MONOMER.

Family and domain databases

HAMAPiMF_00393. Glyc3P_acyltrans.
InterProiIPR022284. GPAT/DHAPAT.
IPR028354. GPAT_PlsB.
IPR002123. Plipid/glycerol_acylTrfase.
[Graphical view]
PANTHERiPTHR12563. PTHR12563. 2 hits.
PfamiPF01553. Acyltransferase. 1 hit.
[Graphical view]
PIRSFiPIRSF500064. GPAT. 1 hit.
PIRSF000437. GPAT_DHAPAT. 1 hit.
SMARTiSM00563. PlsC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03703. plsB. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Vibrio vulnificus CMCP6."
    Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E.
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CMCP6.

Entry informationi

Entry nameiPLSB_VIBVU
AccessioniPrimary (citable) accession number: Q8DD48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2003
Last sequence update: March 1, 2003
Last modified: November 11, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.