Reviewed, UniProtKB/Swiss-Prot Q8DD46 (STHA_VIBVU)

Names and origin

Protein names

Recommended name:
    Soluble pyridine nucleotide transhydrogenase
      Short name=STH
    EC=1.6.1.1
Alternative name(s):
    NAD(P)(+) transhydrogenase [B-specific]

Gene names

Name:	sthA
Ordered Locus Names:	VV1_1168

Organism

Vibrio vulnificus [Complete proteome] [HAMAP]

Taxonomic identifier

672 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length	466 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation By similarity.
Catalytic activity	NADPH + NAD+ = NADP+ + NADH. HAMAP MF_00247
Cofactor	Binds 1 FAD per subunit By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	FAD Flavoprotein NAD NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	NADP metabolic process Inferred from electronic annotation. Source: HAMAP cell redox homeostasis Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro NAD(P)+ transhydrogenase (B-specific) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 466	466	Soluble pyridine nucleotide transhydrogenase HAMAP MF_00247		PRO_0000068077
Regions
	Nucleotide binding	36 – 45	10	FAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8DD46-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: A4DD36396FA20C01	FASTA	466	50,955
	10 20 30 40 50 60 MAHANHFDVI VIGSGPGGEG AAMGLTKAGL KVAVVEKESS VGGGCTHWGT IPSKALRHAV 70 80 90 100 110 120 SRIIEFNSNP LFCKNNSSLH ATFSTILGHA KSVIDKQTRL RQGFYDRNQC QLIFGTARFT 130 140 150 160 170 180 DAHTISVTQN DGTEEVYTAD KFVIATGSRP YQPADVDFNH ERIYDSDSIL SLKHDPRHII 190 200 210 220 230 240 IYGAGVIGCE YASIFRGLGV KTDLINTRDR LLAFLDNEVS DALSYHFWNS GVVIRNDETY 250 260 270 280 290 300 ERIEGTEDGV IVHLQSGKKM KADCLLYANG RTGNTDKLNL PAVGLQGDSR GQLKVDGNYQ 310 320 330 340 350 360 TEVEHVYAVG DVIGYPSLAS AAYDQGRFVA QAITKGKADG YLIDDIPTGI YTIPEISSVG 370 380 390 400 410 420 KTEQELTAAK VPYEVGRSSF KHLARAQIAG KDIGSLKILF HRETKEILGI HCFGERAAEI 430 440 450 460 IHIGQAIMEQ KGEANTIEYF VNTTFNYPTM AEAYRVAALN GLNRLF

References

[1]	"Complete genome sequence of Vibrio vulnificus CMCP6." Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E. Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CMCP6.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE016795 Genomic DNA. Translation: AAO09639.1.
RefSeq	NP_760112.1.
3D structure databases
HSSP	HSSP built from PDB template 1LPF based on UniProtKB P14218.
ModBase	Search...
Genome annotation databases
GeneID	1178094.
GenomeReviews	Gene locus VV1_1168 in contig AE016795_GR.
KEGG	vvu:VV1_1168.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8DD46.
OMA	Q8DD46. GEGNTIE.
Enzyme and pathway databases
BioCyc	VVUL216895:VV1_1168-MON.
BRENDA	1.6.1.1. 277169.
Family and domain databases
HAMAP	MF_00247. [Tree]
InterPro	IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR000815. Hg_reductase. IPR004099. Pyr_nucl-diS_OxRdtase_dimer. IPR001327. Pyr_OxRdtase_NAD_bd. [Graphical view]
Gene3D	G3DSA:3.30.390.30. Pyr_redox_dim. 1 hit.
Pfam	PF00070. Pyr_redox. 1 hit. PF07992. Pyr_redox_2. 1 hit. PF02852. Pyr_redox_dim. 1 hit. [Graphical view]
PRINTS	PR00368. FADPNR. PR00945. HGRDTASE.
ProDom	PD000139. FAD_pyr_redox. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

STHA_VIBVU

Accession

Primary (citable) accession number: Q8DD46

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2003
Last sequence update:	March 1, 2003
Last modified:	June 16, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)