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Protein

Pantothenate kinase

Gene

coaA

Organism
Vibrio vulnificus (strain CMCP6)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate.UniRule annotation

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CoA from (R)-pantothenate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Pantothenate kinase (coaA)
  2. Coenzyme A biosynthesis bifunctional protein CoaBC (coaBC)
  3. Coenzyme A biosynthesis bifunctional protein CoaBC (coaBC)
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi87 – 948ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Coenzyme A biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciVVUL216895:GIYM-1073-MONOMER.
UniPathwayiUPA00241; UER00352.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate kinaseUniRule annotation (EC:2.7.1.33UniRule annotation)
Alternative name(s):
Pantothenic acid kinaseUniRule annotation
Gene namesi
Name:coaAUniRule annotation
Ordered Locus Names:VV1_1200
OrganismiVibrio vulnificus (strain CMCP6)
Taxonomic identifieri216895 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307Pantothenate kinasePRO_0000194461Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi216895.VV1_1200.

Structurei

3D structure databases

ProteinModelPortaliQ8DD30.
SMRiQ8DD30. Positions 1-307.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prokaryotic pantothenate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CS9. Bacteria.
COG1072. LUCA.
HOGENOMiHOG000248571.
KOiK00867.
OMAiLMQRKGF.
OrthoDBiPOG091H073G.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00215. Pantothen_kinase_1. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR004566. PanK_bact.
IPR006083. PRK/URK.
[Graphical view]
PANTHERiPTHR10285:SF7. PTHR10285:SF7. 2 hits.
PfamiPF00485. PRK. 1 hit.
[Graphical view]
PIRSFiPIRSF000545. Pantothenate_kin. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00554. panK_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8DD30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPFLSFSRA TWSELRNSVP MTLSEEDLKA LQGINENLTM QEAVEVYLPL
60 70 80 90 100
SRLLNLYVQA RQSRNSVLHQ FLNNDEHAPP FVIGIAGSVA VGKSTTARVL
110 120 130 140 150
CALLSRWENH PKVELVTTDG FLYPKKELDQ RGIMHKKGFP ESYDMKKLVQ
160 170 180 190 200
FVSDVKAGKP ELEVPVYSHI TYDITEEVKK VDRPDVLIIE GLNVLQSGMD
210 220 230 240 250
YPHDPHRVFV SDFLDFSIYV DAESNTIEQW YVERFLKFRK GAFTQPGSYF
260 270 280 290 300
SHYTQLSEQQ AIEKAQQIWR DINGINLTEN ILPTKERAQL ILRKGPNHLV

EEILLRK
Length:307
Mass (Da):35,278
Last modified:March 1, 2003 - v1
Checksum:iE4B5D76166C8F81D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016795 Genomic DNA. Translation: AAO09661.1.
RefSeqiWP_011079193.1. NC_004459.3.

Genome annotation databases

EnsemblBacteriaiAAO09661; AAO09661; VV1_1200.
KEGGivvu:VV1_1200.
PATRICi20159191. VBIVibVul94426_1127.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016795 Genomic DNA. Translation: AAO09661.1.
RefSeqiWP_011079193.1. NC_004459.3.

3D structure databases

ProteinModelPortaliQ8DD30.
SMRiQ8DD30. Positions 1-307.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi216895.VV1_1200.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO09661; AAO09661; VV1_1200.
KEGGivvu:VV1_1200.
PATRICi20159191. VBIVibVul94426_1127.

Phylogenomic databases

eggNOGiENOG4105CS9. Bacteria.
COG1072. LUCA.
HOGENOMiHOG000248571.
KOiK00867.
OMAiLMQRKGF.
OrthoDBiPOG091H073G.

Enzyme and pathway databases

UniPathwayiUPA00241; UER00352.
BioCyciVVUL216895:GIYM-1073-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00215. Pantothen_kinase_1. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR004566. PanK_bact.
IPR006083. PRK/URK.
[Graphical view]
PANTHERiPTHR10285:SF7. PTHR10285:SF7. 2 hits.
PfamiPF00485. PRK. 1 hit.
[Graphical view]
PIRSFiPIRSF000545. Pantothenate_kin. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00554. panK_bact. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOAA_VIBVU
AccessioniPrimary (citable) accession number: Q8DD30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.