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Q8DCT6

- SYW_VIBVU

UniProt

Q8DCT6 - SYW_VIBVU

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Protein
Tryptophan--tRNA ligase
Gene
trpS, VV1_1307
Organism
Vibrio vulnificus (strain CMCP6)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei201 – 2011ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciVVUL216895:GIYM-1170-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligase (EC:6.1.1.2)
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name:
TrpRS
Gene namesi
Name:trpS
Ordered Locus Names:VV1_1307
OrganismiVibrio vulnificus (strain CMCP6)
Taxonomic identifieri216895 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000002275: Chromosome 1

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 338338Tryptophan--tRNA ligaseUniRule annotation
PRO_0000136708Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi216895.VV1_1307.

Structurei

3D structure databases

ProteinModelPortaliQ8DCT6.
SMRiQ8DCT6. Positions 5-335.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi12 – 209"HIGH" regionUniRule annotation
Motifi198 – 2025"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0180.
HOGENOMiHOG000059940.
KOiK01867.
OMAiLLNCYTY.
OrthoDBiEOG686NJQ.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00140_B. Trp_tRNA_synth_B.
InterProiIPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.
TIGRFAMsiTIGR00233. trpS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8DCT6-1 [UniParc]FASTAAdd to Basket

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MSKPIVLSGV QPSGELSIGN YLGALRQWQQ MQDDYDCQYC VVDLHAITVR    50
QDPKALHEAT LDALAICLAV GVDPKKSTLF VQSHVPEHAQ LGWLLNCYTQ 100
MGELSRMTQF KDKSARYAND VNVGLFGYPV LMAADILLYG AHQVPVGSDQ 150
KQHLELARDI ATRFNNIYSP ENPIFTIPEP YIPTVNARVM SLQDATKKMS 200
KSDDNRKNVI TLLEDPKSII KKINKAQTDT ETPPRIAHDW DNKAGISNLM 250
GLYSAATGMS FEEIEAKYQG VEMYGPFKKD VGEALVSMLE PIQAEYHRIR 300
EDRGYMNEVM RQGADKASAR AAETLKKVYE VVGFVGRP 338
Length:338
Mass (Da):37,772
Last modified:March 1, 2003 - v1
Checksum:i33C473E9D5F57F01
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016795 Genomic DNA. Translation: AAO09762.1.
RefSeqiNP_760235.1. NC_004459.3.
WP_011079289.1. NC_004459.3.

Genome annotation databases

EnsemblBacteriaiAAO09762; AAO09762; VV1_1307.
GeneIDi1178234.
KEGGivvu:VV1_1307.
PATRICi20159422. VBIVibVul94426_1229.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016795 Genomic DNA. Translation: AAO09762.1 .
RefSeqi NP_760235.1. NC_004459.3.
WP_011079289.1. NC_004459.3.

3D structure databases

ProteinModelPortali Q8DCT6.
SMRi Q8DCT6. Positions 5-335.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 216895.VV1_1307.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO09762 ; AAO09762 ; VV1_1307 .
GeneIDi 1178234.
KEGGi vvu:VV1_1307.
PATRICi 20159422. VBIVibVul94426_1229.

Phylogenomic databases

eggNOGi COG0180.
HOGENOMi HOG000059940.
KOi K01867.
OMAi LLNCYTY.
OrthoDBi EOG686NJQ.

Enzyme and pathway databases

BioCyci VVUL216895:GIYM-1170-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00140_B. Trp_tRNA_synth_B.
InterProi IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view ]
PANTHERi PTHR10055. PTHR10055. 1 hit.
Pfami PF00579. tRNA-synt_1b. 1 hit.
[Graphical view ]
PRINTSi PR01039. TRNASYNTHTRP.
TIGRFAMsi TIGR00233. trpS. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Vibrio vulnificus CMCP6."
    Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E.
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CMCP6.

Entry informationi

Entry nameiSYW_VIBVU
AccessioniPrimary (citable) accession number: Q8DCT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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