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Q8DCN0

- ASSY_VIBVU

UniProt

Q8DCN0 - ASSY_VIBVU

Protein

Argininosuccinate synthase

Gene

argG

Organism
Vibrio vulnificus (strain CMCP6)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 2 (01 Mar 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei39 – 391ATP; via amide nitrogen and carbonyl oxygenUniRule annotation
    Binding sitei91 – 911CitrullineUniRule annotation
    Binding sitei96 – 961CitrullineUniRule annotation
    Binding sitei121 – 1211ATP; via amide nitrogenUniRule annotation
    Binding sitei123 – 1231AspartateUniRule annotation
    Binding sitei127 – 1271AspartateUniRule annotation
    Binding sitei127 – 1271CitrullineUniRule annotation
    Binding sitei128 – 1281AspartateUniRule annotation
    Binding sitei131 – 1311CitrullineUniRule annotation
    Binding sitei180 – 1801CitrullineUniRule annotation
    Binding sitei189 – 1891CitrullineUniRule annotation
    Binding sitei265 – 2651CitrullineUniRule annotation
    Binding sitei277 – 2771CitrullineUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi12 – 209ATPUniRule annotation

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciVVUL216895:GIYM-1228-MONOMER.
    UniPathwayiUPA00068; UER00113.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
    Alternative name(s):
    Citrulline--aspartate ligaseUniRule annotation
    Gene namesi
    Name:argGUniRule annotation
    Ordered Locus Names:VV1_1373
    OrganismiVibrio vulnificus (strain CMCP6)
    Taxonomic identifieri216895 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000002275: Chromosome 1

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 403403Argininosuccinate synthasePRO_0000148663Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi216895.VV1_1373.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8DCN0.
    SMRiQ8DCN0. Positions 8-401.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0137.
    HOGENOMiHOG000230093.
    KOiK01940.
    OMAiPECEYIR.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00005. Arg_succ_synth_type1.
    InterProiIPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8DCN0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKLNVNKVV VAYSGGLDTS VIIPWLKENY DCEVVAFVAD VGQGEEELVG    50
    IEEKAKASGA SECYVVDLKE ELVADYIYPT LKTGAYYEGK YLLGTSMARP 100
    VIAKAQVEIA RKVGADALCH GCTGKGNDQV RFEGAFAALA PDLKVIAPWR 150
    EWDLVSREQC LDYLAERNIP CAASLTKIYS RDANAWHIST EGGVLESTWN 200
    APNEDCWVWT VDPEQAPNEA EYVTLQVEKG EVVAVDGEQM TPYNALVYLN 250
    EKGAKHGVGR IDIVENRLVG MKSRGCYETP GGTIMMEALR AVEQLVLDKT 300
    SFEFREELGL KASHLVYDGR WFTPLRKSIM AAADELAQDV NGEVVVKLYK 350
    GMATVTQKRS ENSLYSEAFA TFGEDEVYDQ SHAGGFIRLY SLSSRIRALN 400
    SQK 403
    Length:403
    Mass (Da):44,504
    Last modified:March 1, 2004 - v2
    Checksum:iDCB3370FB012F31E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016795 Genomic DNA. Translation: AAO09822.2.
    RefSeqiNP_760295.2. NC_004459.3.
    WP_011079347.1. NC_004459.3.

    Genome annotation databases

    EnsemblBacteriaiAAO09822; AAO09822; VV1_1373.
    GeneIDi1178294.
    KEGGivvu:VV1_1373.
    PATRICi20159540. VBIVibVul94426_1288.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016795 Genomic DNA. Translation: AAO09822.2 .
    RefSeqi NP_760295.2. NC_004459.3.
    WP_011079347.1. NC_004459.3.

    3D structure databases

    ProteinModelPortali Q8DCN0.
    SMRi Q8DCN0. Positions 8-401.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 216895.VV1_1373.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO09822 ; AAO09822 ; VV1_1373 .
    GeneIDi 1178294.
    KEGGi vvu:VV1_1373.
    PATRICi 20159540. VBIVibVul94426_1288.

    Phylogenomic databases

    eggNOGi COG0137.
    HOGENOMi HOG000230093.
    KOi K01940.
    OMAi PECEYIR.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .
    BioCyci VVUL216895:GIYM-1228-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00005. Arg_succ_synth_type1.
    InterProi IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Vibrio vulnificus CMCP6."
      Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E.
      Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CMCP6.

    Entry informationi

    Entry nameiASSY_VIBVU
    AccessioniPrimary (citable) accession number: Q8DCN0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2003
    Last sequence update: March 1, 2004
    Last modified: October 1, 2014
    This is version 85 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3