Reviewed, UniProtKB/Swiss-Prot Q8DCL0 (ALR1_VIBVU)

Names and origin

Protein names

Recommended name:
    Alanine racemase 1
    EC=5.1.1.1

Gene names

Name:	alr1
Ordered Locus Names:	VV1_1393

Organism

Vibrio vulnificus [Complete proteome] [HAMAP]

Taxonomic identifier

672 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length	358 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Provides the D-alanine required for cell wall biosynthesis By similarity.
Catalytic activity	L-alanine = D-alanine. HAMAP MF_01201
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP MF_01201 Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_01201
Sequence similarities	Belongs to the alanine racemase family.

Ontologies

Keywords
Biological process	Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Ligand	Pyridoxal phosphate
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	alanine metabolic process Inferred from electronic annotation. Source: HAMAP cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: HAMAP regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alanine racemase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 358	358	Alanine racemase 1 HAMAP MF_01201		PRO_0000114595
Sites
	Active site	34	1	Proton acceptor; specific for D-alanine By similarity
	Active site	254	1	Proton acceptor; specific for L-alanine By similarity
Amino acid modifications
	Modified residue	34	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8DCL0-1 [UniParc]. Last modified August 15, 2003. Version 2. Checksum: 94F6F244084610C9	FASTA	358	38,990
	10 20 30 40 50 60 MKAATACIDL VALQHNLQLI KQQAPHSKLM AVVKANGYGH GLRHVAKHAV GADAFGVARI 70 80 90 100 110 120 EEALQLRACG VVKPILLLEG FYSSGDLPVL VTNNIQTVVH CEEQLRDLEN AELETPVVVW 130 140 150 160 170 180 LKIDSGMHRL GVRPEQYQAF VERLHQCPNV AKPLRYMSHF GCADEMNNEM TPKQIELFLS 190 200 210 220 230 240 LTRGCKGERS LAASAGLLAW QESQLEWVRP GIIMYGVSPF GDKTASELGY KPVMTLKSHL 250 260 270 280 290 300 IAVRDVKAGE SVGYGATWIS ERDTKVGVIA IGYGDGYPRT APNGTPVLVN GRKVPIAGRV 310 320 330 340 350 SMDMLTVDLG PDATDHVGDE AILWGADLPA EDVAQHIGTI AYELVTKLTS RVEMSYSE

References

[1]	"Complete genome sequence of Vibrio vulnificus CMCP6." Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E. Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CMCP6.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE016795 Genomic DNA. Translation: AAO09842.1. Different initiation.
RefSeq	NP_760315.1.
3D structure databases
HSSP	HSSP built from PDB template 1BD0 based on UniProtKB P10724.
ModBase	Search...
Genome annotation databases
GeneID	1178314.
GenomeReviews	Gene locus VV1_1393 in contig AE016795_GR.
KEGG	vvu:VV1_1393.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8DCL0.
Enzyme and pathway databases
BioCyc	VVUL216895:VV1_1393-MON.
BRENDA	5.1.1.1. 277169.
Family and domain databases
HAMAP	MF_01201. [Tree]
InterPro	IPR011079. Ala_racemase_C. IPR001608. Ala_racemase_N. IPR000821. Ala_racemase_reg. [Graphical view]
Pfam	PF00842. Ala_racemase_C. 1 hit. PF01168. Ala_racemase_N. 1 hit. [Graphical view]
PRINTS	PR00992. ALARACEMASE.
TIGRFAMs	TIGR00492. alr. 1 hit.
PROSITE	PS00395. ALANINE_RACEMASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALR1_VIBVU

Accession

Primary (citable) accession number: Q8DCL0

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 15, 2003
Last sequence update:	August 15, 2003
Last modified:	May 26, 2009
This is version 45 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)