Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Vibrio vulnificus (strain CMCP6)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathway:iglycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. ATP-dependent 6-phosphofructokinase (pfkA)
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei356 – 3561Proton donorUniRule annotation
Active sitei387 – 3871UniRule annotation
Active sitei515 – 5151UniRule annotation

GO - Molecular functioni

  • glucose-6-phosphate isomerase activity Source: CACAO

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciVVUL216895:GIYM-1252-MONOMER.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:VV1_1396
OrganismiVibrio vulnificus (strain CMCP6)
Taxonomic identifieri216895 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 550550Glucose-6-phosphate isomerasePRO_0000180765Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi216895.VV1_1396.

Structurei

3D structure databases

ProteinModelPortaliQ8DCK7.
SMRiQ8DCK7. Positions 21-546.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261370.
KOiK01810.
OMAiSHLIAPY.
OrthoDBiEOG64R61J.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8DCK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKTINPTQT QAWNALTAHF ESAQDMDLKD LFAQDAARFD KFSARFGSDI
60 70 80 90 100
LVDYSKNLIN EETLKHLFAL AKETELSAAI KAMFSGEAIN QTEGRAVLHT
110 120 130 140 150
ALRNRSNQPV LVDGEDVMPA VNAVLEKMKS FTDRVIGGEW KGYTGKAITD
160 170 180 190 200
IVNIGIGGSD LGPYMVTEAL APYKNHLNLH FVSNVDGTHI VETLKKVDPE
210 220 230 240 250
TTLFLIASKT FTTQETMTNA HTARDWFLAT AGDQAHVAKH FAALSTNAPA
260 270 280 290 300
VSEFGIDTDN MFEFWDWVGG RYSLWSAIGL SIALAVGYDN FIELLEGAHE
310 320 330 340 350
MDNHFVSTEL ESNIPVILAL IGIWYNNFHG AESEAILPYD QYMHRFAAYF
360 370 380 390 400
QQGNMESNGK YVDRNGNPVT YQTGPIIWGE PGTNGQHAFY QLIHQGTKLI
410 420 430 440 450
PCDFIAPAVS HNPAGDHHQK LMSNFFAQTE ALAFGKNEET VKAELVKAGK
460 470 480 490 500
NAEEVAAIAP FKVFEGNRPT NSILVKQITP RTLGNLIAMY EHKIFVQGVI
510 520 530 540 550
WNIFSFDQWG VELGKQLANQ ILPELADGSE ISSHDSSTNG LINAFKAFKA
Length:550
Mass (Da):60,758
Last modified:March 1, 2003 - v1
Checksum:iBFEF63D793997758
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016795 Genomic DNA. Translation: AAO09845.1.
RefSeqiWP_011079370.1. NC_004459.3.

Genome annotation databases

EnsemblBacteriaiAAO09845; AAO09845; VV1_1396.
KEGGivvu:VV1_1396.
PATRICi20159588. VBIVibVul94426_1312.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016795 Genomic DNA. Translation: AAO09845.1.
RefSeqiWP_011079370.1. NC_004459.3.

3D structure databases

ProteinModelPortaliQ8DCK7.
SMRiQ8DCK7. Positions 21-546.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi216895.VV1_1396.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO09845; AAO09845; VV1_1396.
KEGGivvu:VV1_1396.
PATRICi20159588. VBIVibVul94426_1312.

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261370.
KOiK01810.
OMAiSHLIAPY.
OrthoDBiEOG64R61J.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.
BioCyciVVUL216895:GIYM-1252-MONOMER.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Vibrio vulnificus CMCP6."
    Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E.
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CMCP6.

Entry informationi

Entry nameiG6PI_VIBVU
AccessioniPrimary (citable) accession number: Q8DCK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: March 1, 2003
Last modified: July 22, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.