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Q8DCC3

- TRMB_VIBVU

UniProt

Q8DCC3 - TRMB_VIBVU

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Vibrio vulnificus (strain CMCP6)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei68 – 681S-adenosyl-L-methionineUniRule annotation
Binding sitei93 – 931S-adenosyl-L-methionineUniRule annotation
Binding sitei120 – 1201S-adenosyl-L-methionineUniRule annotation
Active sitei143 – 1431By similarity
Binding sitei143 – 1431S-adenosyl-L-methionineUniRule annotation
Binding sitei147 – 1471SubstrateUniRule annotation
Binding sitei180 – 1801SubstrateUniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciVVUL216895:GIYM-1334-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:VV1_1516
OrganismiVibrio vulnificus (strain CMCP6)
Taxonomic identifieri216895 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000002275: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 239239tRNA (guanine-N(7)-)-methyltransferasePRO_0000171420Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi216895.VV1_1516.

Structurei

3D structure databases

ProteinModelPortaliQ8DCC3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni217 – 2204Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000073968.
KOiK03439.
OMAiTSATNDY.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8DCC3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSEVTTNEYN EDGKLIRKIR SFVRREGRLT KGQENAMKEC WPTMGIDYQK
60 70 80 90 100
QLLDWKEVFG NDNPVVLEIG FGMGASLVEM AKNAPEKNFF GIEVHSPGVG
110 120 130 140 150
ACLSDAREAG ISNLRVMCHD AVEVFEHMIP NDSLATLQLF FPDPWHKKRH
160 170 180 190 200
HKRRIVQLEF AEMVRQKLIP NEGIFHMATD WENYAEHMIE IMNQAPGYRN
210 220 230
IAEAGDYIPR PEERPLTKFE ARGHRLGHGV WDIKFKRVS
Length:239
Mass (Da):27,594
Last modified:March 1, 2003 - v1
Checksum:i36C85E69178CD70A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016795 Genomic DNA. Translation: AAO09942.1.
RefSeqiNP_760415.1. NC_004459.3.
WP_011079452.1. NC_004459.3.

Genome annotation databases

EnsemblBacteriaiAAO09942; AAO09942; VV1_1516.
GeneIDi1178431.
KEGGivvu:VV1_1516.
PATRICi20159811. VBIVibVul94426_1399.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016795 Genomic DNA. Translation: AAO09942.1 .
RefSeqi NP_760415.1. NC_004459.3.
WP_011079452.1. NC_004459.3.

3D structure databases

ProteinModelPortali Q8DCC3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 216895.VV1_1516.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO09942 ; AAO09942 ; VV1_1516 .
GeneIDi 1178431.
KEGGi vvu:VV1_1516.
PATRICi 20159811. VBIVibVul94426_1399.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000073968.
KOi K03439.
OMAi TSATNDY.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci VVUL216895:GIYM-1334-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Vibrio vulnificus CMCP6."
    Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E.
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CMCP6.

Entry informationi

Entry nameiTRMB_VIBVU
AccessioniPrimary (citable) accession number: Q8DCC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3