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Protein

tRNA pseudouridine synthase D

Gene

truD

Organism
Vibrio vulnificus (strain CMCP6)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.UniRule annotation

Catalytic activityi

tRNA uridine(13) = tRNA pseudouridine(13).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei81NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

tRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA pseudouridine synthase DUniRule annotation (EC:5.4.99.27UniRule annotation)
Alternative name(s):
tRNA pseudouridine(13) synthaseUniRule annotation
tRNA pseudouridylate synthase DUniRule annotation
tRNA-uridine isomerase DUniRule annotation
Gene namesi
Name:truDUniRule annotation
Ordered Locus Names:VV1_1584
OrganismiVibrio vulnificus (strain CMCP6)
Taxonomic identifieri216895 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001525281 – 347tRNA pseudouridine synthase DAdd BLAST347

Interactioni

Protein-protein interaction databases

STRINGi216895.VV1_1584.

Structurei

3D structure databases

ProteinModelPortaliQ8DC58.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini158 – 304TRUDUniRule annotationAdd BLAST147

Sequence similaritiesi

Belongs to the pseudouridine synthase TruD family.UniRule annotation
Contains 1 TRUD domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4106NZV. Bacteria.
COG0585. LUCA.
HOGENOMiHOG000224848.
KOiK06176.
OMAiLWLWVEK.
OrthoDBiPOG091H03KK.

Family and domain databases

HAMAPiMF_01082. TruD. 1 hit.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR001656. PsdUridine_synth_TruD.
IPR020119. PsdUridine_synth_TruD_CS.
IPR011760. PsdUridine_synth_TruD_insert.
[Graphical view]
PANTHERiPTHR13326. PTHR13326. 1 hit.
PfamiPF01142. TruD. 2 hits.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
TIGRFAMsiTIGR00094. tRNA_TruD_broad. 1 hit.
PROSITEiPS50984. TRUD. 1 hit.
PS01268. UPF0024. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8DC58-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDTLASLAY LAGKPTAQAK IKAKPEHFQV REDLGFEFTG SGEHLMVRIR
60 70 80 90 100
KTGENTSFVA NELAKACGVK SKDVSWAGLK DRHAVTEQWL SVHLPKAETP
110 120 130 140 150
DFSAFLAQYP SIEILTTARH NKKLRPGDLV GNDFVVTLSE VSDVDDVLKR
160 170 180 190 200
LETVAKLGVP NYFGNQRFGN NGNNLQEAKR WGRDNVRSRN QNQRSLYLSA
210 220 230 240 250
ARSWIFNLIV SARLEQSLFD KVLLGDILFK GDEQLLVSAE NHADLQSQYD
260 270 280 290 300
AGDLVISGAL AGDNALPTQD DALALEQVFL DAEPDLMALI RGNRMRHDRR
310 320 330 340
AIALKPANLS WQVDGNNIIL TFSLDAGSFA TSIIRELVQE IAFEREF
Length:347
Mass (Da):38,554
Last modified:March 1, 2003 - v1
Checksum:i5B5B3ED1F99C1D59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016795 Genomic DNA. Translation: AAO10007.1.
RefSeqiWP_011079517.1. NC_004459.3.

Genome annotation databases

EnsemblBacteriaiAAO10007; AAO10007; VV1_1584.
KEGGivvu:VV1_1584.
PATRICi20159949. VBIVibVul94426_1468.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016795 Genomic DNA. Translation: AAO10007.1.
RefSeqiWP_011079517.1. NC_004459.3.

3D structure databases

ProteinModelPortaliQ8DC58.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi216895.VV1_1584.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO10007; AAO10007; VV1_1584.
KEGGivvu:VV1_1584.
PATRICi20159949. VBIVibVul94426_1468.

Phylogenomic databases

eggNOGiENOG4106NZV. Bacteria.
COG0585. LUCA.
HOGENOMiHOG000224848.
KOiK06176.
OMAiLWLWVEK.
OrthoDBiPOG091H03KK.

Family and domain databases

HAMAPiMF_01082. TruD. 1 hit.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR001656. PsdUridine_synth_TruD.
IPR020119. PsdUridine_synth_TruD_CS.
IPR011760. PsdUridine_synth_TruD_insert.
[Graphical view]
PANTHERiPTHR13326. PTHR13326. 1 hit.
PfamiPF01142. TruD. 2 hits.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
TIGRFAMsiTIGR00094. tRNA_TruD_broad. 1 hit.
PROSITEiPS50984. TRUD. 1 hit.
PS01268. UPF0024. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRUD_VIBVU
AccessioniPrimary (citable) accession number: Q8DC58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.