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Q8DC12

- PANC_VIBVU

UniProt

Q8DC12 - PANC_VIBVU

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Protein
Pantothenate synthetase
Gene
panC, VV1_1642
Organism
Vibrio vulnificus (strain CMCP6)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate By similarity.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei37 – 371Proton donor By similarity
Binding sitei61 – 611Beta-alanine By similarity
Binding sitei61 – 611Pantoate By similarity
Binding sitei155 – 1551Pantoate By similarity
Binding sitei178 – 1781ATP; via amide nitrogen and carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi30 – 378ATP By similarity
Nucleotide bindingi149 – 1524ATP By similarity
Nucleotide bindingi186 – 1894ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciVVUL216895:GIYM-1446-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetase (EC:6.3.2.1)
Short name:
PS
Alternative name(s):
Pantoate--beta-alanine ligase
Pantoate-activating enzyme
Gene namesi
Name:panC
Ordered Locus Names:VV1_1642
OrganismiVibrio vulnificus (strain CMCP6)
Taxonomic identifieri216895 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000002275: Chromosome 1

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 301301Pantothenate synthetaseUniRule annotation
PRO_0000128287Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi216895.VV1_1642.

Structurei

3D structure databases

ProteinModelPortaliQ8DC12.
SMRiQ8DC12. Positions 1-282.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0414.
HOGENOMiHOG000175516.
KOiK01918.
OMAiIHTIREL.
OrthoDBiEOG6Z6FZ4.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR004821. Cyt_trans-like.
IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
TIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8DC12-1 [UniParc]FASTAAdd to Basket

« Hide

MQTFAEISAL REQIKTFKRE GRRIAFVPTM GNLHEGHLTL VRKAREHADI    50
VVVSIFVNPM QFDRADDLNN YPRTLEDDLS KLNGEAVELV FTPTPEMIYP 100
EGLDKQTLVE VPGLSTMLEG ASRPGHFRGV ATVVTKLFNI VQPDVACFGE 150
KDFQQLAIIR KMTTDLAMDI EIIGVPTVRE MDGLAMSSRN GLLTIDERQR 200
APVLARTMRW ISSAIRGGRD DFASIIEDAS DQLRAAGLHP DEIFIRDART 250
LQVVNAESTQ AVILMSAFLG KARLIDNQVV ELVKDSKEEV DSAESESENS 300
H 301
Length:301
Mass (Da):33,534
Last modified:March 1, 2003 - v1
Checksum:i2D31ABBC162D8285
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016795 Genomic DNA. Translation: AAO10059.1.
RefSeqiNP_760532.1. NC_004459.3.
WP_011079564.1. NC_004459.3.

Genome annotation databases

EnsemblBacteriaiAAO10059; AAO10059; VV1_1642.
GeneIDi1178556.
KEGGivvu:VV1_1642.
PATRICi20160068. VBIVibVul94426_1519.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016795 Genomic DNA. Translation: AAO10059.1 .
RefSeqi NP_760532.1. NC_004459.3.
WP_011079564.1. NC_004459.3.

3D structure databases

ProteinModelPortali Q8DC12.
SMRi Q8DC12. Positions 1-282.
ModBasei Search...

Protein-protein interaction databases

STRINGi 216895.VV1_1642.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO10059 ; AAO10059 ; VV1_1642 .
GeneIDi 1178556.
KEGGi vvu:VV1_1642.
PATRICi 20160068. VBIVibVul94426_1519.

Phylogenomic databases

eggNOGi COG0414.
HOGENOMi HOG000175516.
KOi K01918.
OMAi IHTIREL.
OrthoDBi EOG6Z6FZ4.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .
BioCyci VVUL216895:GIYM-1446-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
InterProi IPR004821. Cyt_trans-like.
IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR21299:SF1. PTHR21299:SF1. 1 hit.
Pfami PF02569. Pantoate_ligase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00125. cyt_tran_rel. 1 hit.
TIGR00018. panC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Vibrio vulnificus CMCP6."
    Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E.
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CMCP6.

Entry informationi

Entry nameiPANC_VIBVU
AccessioniPrimary (citable) accession number: Q8DC12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2003
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism By similarity.

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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