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Q8DBW0 (IF2_VIBVU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Translation initiation factor IF-2
Gene names
Name:infB
Ordered Locus Names:VV1_1696
OrganismVibrio vulnificus (strain CMCP6) [Complete proteome] [HAMAP]
Taxonomic identifier216895 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length907 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex By similarity. HAMAP-Rule MF_00100

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00100.

Sequence similarities

Belongs to the IF-2 family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandGTP-binding
Nucleotide-binding
   Molecular functionInitiation factor
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

GTPase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

translation initiation factor activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 907907Translation initiation factor IF-2 HAMAP-Rule MF_00100
PRO_0000137281

Regions

Nucleotide binding415 – 4228GTP By similarity
Nucleotide binding461 – 4655GTP By similarity
Nucleotide binding515 – 5184GTP By similarity
Region409 – 557149G-domain HAMAP-Rule MF_00100

Sequences

Sequence LengthMass (Da)Tools
Q8DBW0 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: EDBEDE3C24F8705D

FASTA90799,590
        10         20         30         40         50         60 
MTQLTVKALS EEIGTPVDRL LEQLADAGMK KSSSDQVSDE EKQKLLTHLK KEHGDTSGDA 

        70         80         90        100        110        120 
EPTRLTLQRK TRSTLSVNAG GGKSKDVQIE VRKKRTYVKR SAIEDEAKRE AEEAAQREAE 

       130        140        150        160        170        180 
EAAKRAAEEA AKREAEEAAK REAEEKAKRE AEEAAKREAE KSVDRDAEEK AKRDAEGKAK 

       190        200        210        220        230        240 
RDAEEKVKQE AARKEAEELK RRQEEEAKRK AEEESQRKLE EAREMAEKNK ERWSAAEENK 

       250        260        270        280        290        300 
GDMEDTDYHV TTSQYAREAE DEADRKEEEA RRRKKKTKSS AKASENDERG GPRVQRGGKG 

       310        320        330        340        350        360 
GRKGKLSKPK SMQHGFDKSA VVAKSDVVIG ETIVVSELAN KMSVKATEVI KIMMKMGAMA 

       370        380        390        400        410        420 
TINQVIDQET AQLVAEEMGH KVVLRKENEL EEAVLSDRDN MFEAVPRAPV VTIMGHVDHG 

       430        440        450        460        470        480 
KTSTLDYIRR THVASGEAGG ITQHIGAYHV ETENGMITFL DTPGHAAFTA MRARGAQATD 

       490        500        510        520        530        540 
IVVLVVAADD GVMPQTVEAI QHAKAAGVPL IVAVNKIDKE EANPDNVKNE LSQYNVMPEE 

       550        560        570        580        590        600 
WGGENMFVHI SAKQGTNIDQ LLETILLQAE VLELTAVKDG MASGVVVESR LDKGRGPVAT 

       610        620        630        640        650        660 
VLVQSGTLRK GDIVLCGQEY GRVRAMRDEI GNEVNEAGPS IPVEILGLSG VPAAGDEATV 

       670        680        690        700        710        720 
VRDERKAREV ANYRAGKFRE VKLARQQKSK LENMFSNMAA GDVAELNIVL KADVQGSVEA 

       730        740        750        760        770        780 
IADSLTKLST EEVKVNIVGS GVGGITETDA VLAEASNAII LGFNVRADAS ARRAIEAASI 

       790        800        810        820        830        840 
DLRYYSIIYQ LIDEVKQAMS GMLAPEFKQE IIGLAEVRDV FKSPKLGAIA GCMVTEGLIK 

       850        860        870        880        890        900 
RNAPIRVLRD NVVIYEGELE SLRRFKDDVA EVKNGYECGI GVKNYNDVRV GDQIEVFETI 


EIKRTID 

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References

[1]"Complete genome sequence of Vibrio vulnificus CMCP6."
Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E.
Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CMCP6.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016795 Genomic DNA. Translation: AAO10112.1.
RefSeqNP_760585.1. NC_004459.3.

3D structure databases

ProteinModelPortalQ8DBW0.
SMRQ8DBW0. Positions 2-50.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING216895.VV1_1696.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO10112; AAO10112; VV1_1696.
GeneID1178611.
KEGGvvu:VV1_1696.
PATRIC20160183. VBIVibVul94426_1574.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0532.
HOGENOMHOG000076907.
KOK02519.
OMAIKFMFKM.
OrthoDBEOG67HJSV.
ProtClustDBPRK05306.

Enzyme and pathway databases

BioCycVVUL216895:GIYM-1498-MONOMER.

Family and domain databases

Gene3D3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPMF_00100_B. IF_2_B.
InterProIPR009061. DNA-bd_dom_put.
IPR000795. EF_GTP-bd_dom.
IPR013575. IF2_assoc_dom_bac.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF08364. IF2_assoc. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
SUPFAMSSF46955. SSF46955. 1 hit.
SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEPS01176. IF2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIF2_VIBVU
AccessionPrimary (citable) accession number: Q8DBW0
Entry history
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Translation initiation factors

List of translation initiation factor entries