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Protein

Translation initiation factor IF-2

Gene

infB

Organism
Vibrio vulnificus (strain CMCP6)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi415 – 422GTPUniRule annotation8
Nucleotide bindingi461 – 465GTPUniRule annotation5
Nucleotide bindingi515 – 518GTPUniRule annotation4

GO - Molecular functioni

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2UniRule annotation
Gene namesi
Name:infBUniRule annotation
Ordered Locus Names:VV1_1696
OrganismiVibrio vulnificus (strain CMCP6)
Taxonomic identifieri216895 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001372811 – 907Translation initiation factor IF-2Add BLAST907

Structurei

3D structure databases

ProteinModelPortaliQ8DBW0.
SMRiQ8DBW0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini406 – 575tr-type GAdd BLAST170

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni415 – 422G1By similarity8
Regioni440 – 444G2By similarity5
Regioni461 – 464G3By similarity4
Regioni515 – 518G4By similarity4
Regioni551 – 553G5By similarity3

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QHU. Bacteria.
COG0532. LUCA.
HOGENOMiHOG000076907.
KOiK02519.
OMAiDNRTGGY.
OrthoDBiPOG091H00EY.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
HAMAPiMF_00100_B. IF_2_B. 1 hit.
InterProiView protein in InterPro
IPR009061. DNA-bd_dom_put.
IPR013575. IF2_assoc_dom_bac.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
PANTHERiPTHR43381. PTHR43381. 1 hit.
PfamiView protein in Pfam
PF00009. GTP_EFTU. 1 hit.
PF11987. IF-2. 1 hit.
PF08364. IF2_assoc. 1 hit.
PF04760. IF2_N. 2 hits.
SUPFAMiSSF46955. SSF46955. 1 hit.
SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8DBW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQLTVKALS EEIGTPVDRL LEQLADAGMK KSSSDQVSDE EKQKLLTHLK
60 70 80 90 100
KEHGDTSGDA EPTRLTLQRK TRSTLSVNAG GGKSKDVQIE VRKKRTYVKR
110 120 130 140 150
SAIEDEAKRE AEEAAQREAE EAAKRAAEEA AKREAEEAAK REAEEKAKRE
160 170 180 190 200
AEEAAKREAE KSVDRDAEEK AKRDAEGKAK RDAEEKVKQE AARKEAEELK
210 220 230 240 250
RRQEEEAKRK AEEESQRKLE EAREMAEKNK ERWSAAEENK GDMEDTDYHV
260 270 280 290 300
TTSQYAREAE DEADRKEEEA RRRKKKTKSS AKASENDERG GPRVQRGGKG
310 320 330 340 350
GRKGKLSKPK SMQHGFDKSA VVAKSDVVIG ETIVVSELAN KMSVKATEVI
360 370 380 390 400
KIMMKMGAMA TINQVIDQET AQLVAEEMGH KVVLRKENEL EEAVLSDRDN
410 420 430 440 450
MFEAVPRAPV VTIMGHVDHG KTSTLDYIRR THVASGEAGG ITQHIGAYHV
460 470 480 490 500
ETENGMITFL DTPGHAAFTA MRARGAQATD IVVLVVAADD GVMPQTVEAI
510 520 530 540 550
QHAKAAGVPL IVAVNKIDKE EANPDNVKNE LSQYNVMPEE WGGENMFVHI
560 570 580 590 600
SAKQGTNIDQ LLETILLQAE VLELTAVKDG MASGVVVESR LDKGRGPVAT
610 620 630 640 650
VLVQSGTLRK GDIVLCGQEY GRVRAMRDEI GNEVNEAGPS IPVEILGLSG
660 670 680 690 700
VPAAGDEATV VRDERKAREV ANYRAGKFRE VKLARQQKSK LENMFSNMAA
710 720 730 740 750
GDVAELNIVL KADVQGSVEA IADSLTKLST EEVKVNIVGS GVGGITETDA
760 770 780 790 800
VLAEASNAII LGFNVRADAS ARRAIEAASI DLRYYSIIYQ LIDEVKQAMS
810 820 830 840 850
GMLAPEFKQE IIGLAEVRDV FKSPKLGAIA GCMVTEGLIK RNAPIRVLRD
860 870 880 890 900
NVVIYEGELE SLRRFKDDVA EVKNGYECGI GVKNYNDVRV GDQIEVFETI

EIKRTID
Length:907
Mass (Da):99,590
Last modified:March 1, 2003 - v1
Checksum:iEDBEDE3C24F8705D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016795 Genomic DNA. Translation: AAO10112.1.
RefSeqiWP_011079616.1. NC_004459.3.

Genome annotation databases

EnsemblBacteriaiAAO10112; AAO10112; VV1_1696.
KEGGivvu:VV1_1696.

Similar proteinsi

Entry informationi

Entry nameiIF2_VIBVU
AccessioniPrimary (citable) accession number: Q8DBW0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: March 1, 2003
Last modified: August 30, 2017
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families