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Q8DBW0

- IF2_VIBVU

UniProt

Q8DBW0 - IF2_VIBVU

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Protein
Translation initiation factor IF-2
Gene
infB, VV1_1696
Organism
Vibrio vulnificus (strain CMCP6)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi415 – 4228GTP By similarity
Nucleotide bindingi461 – 4655GTP By similarity
Nucleotide bindingi515 – 5184GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. GTPase activity Source: UniProtKB-HAMAP
  3. translation initiation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciVVUL216895:GIYM-1498-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2
Gene namesi
Name:infB
Ordered Locus Names:VV1_1696
OrganismiVibrio vulnificus (strain CMCP6)
Taxonomic identifieri216895 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000002275: Chromosome 1

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 907907Translation initiation factor IF-2UniRule annotation
PRO_0000137281Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi216895.VV1_1696.

Structurei

3D structure databases

ProteinModelPortaliQ8DBW0.
SMRiQ8DBW0. Positions 2-50.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini406 – 575170tr-type G
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni415 – 4228G1 By similarity
Regioni440 – 4445G2 By similarity
Regioni461 – 4644G3 By similarity
Regioni515 – 5184G4 By similarity
Regioni551 – 5533G5 By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0532.
HOGENOMiHOG000076907.
KOiK02519.
OMAiCTIDIDY.
OrthoDBiEOG67HJSV.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B.
InterProiIPR009061. DNA-bd_dom_put.
IPR000795. EF_GTP-bd_dom.
IPR013575. IF2_assoc_dom_bac.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF08364. IF2_assoc. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8DBW0-1 [UniParc]FASTAAdd to Basket

« Hide

MTQLTVKALS EEIGTPVDRL LEQLADAGMK KSSSDQVSDE EKQKLLTHLK    50
KEHGDTSGDA EPTRLTLQRK TRSTLSVNAG GGKSKDVQIE VRKKRTYVKR 100
SAIEDEAKRE AEEAAQREAE EAAKRAAEEA AKREAEEAAK REAEEKAKRE 150
AEEAAKREAE KSVDRDAEEK AKRDAEGKAK RDAEEKVKQE AARKEAEELK 200
RRQEEEAKRK AEEESQRKLE EAREMAEKNK ERWSAAEENK GDMEDTDYHV 250
TTSQYAREAE DEADRKEEEA RRRKKKTKSS AKASENDERG GPRVQRGGKG 300
GRKGKLSKPK SMQHGFDKSA VVAKSDVVIG ETIVVSELAN KMSVKATEVI 350
KIMMKMGAMA TINQVIDQET AQLVAEEMGH KVVLRKENEL EEAVLSDRDN 400
MFEAVPRAPV VTIMGHVDHG KTSTLDYIRR THVASGEAGG ITQHIGAYHV 450
ETENGMITFL DTPGHAAFTA MRARGAQATD IVVLVVAADD GVMPQTVEAI 500
QHAKAAGVPL IVAVNKIDKE EANPDNVKNE LSQYNVMPEE WGGENMFVHI 550
SAKQGTNIDQ LLETILLQAE VLELTAVKDG MASGVVVESR LDKGRGPVAT 600
VLVQSGTLRK GDIVLCGQEY GRVRAMRDEI GNEVNEAGPS IPVEILGLSG 650
VPAAGDEATV VRDERKAREV ANYRAGKFRE VKLARQQKSK LENMFSNMAA 700
GDVAELNIVL KADVQGSVEA IADSLTKLST EEVKVNIVGS GVGGITETDA 750
VLAEASNAII LGFNVRADAS ARRAIEAASI DLRYYSIIYQ LIDEVKQAMS 800
GMLAPEFKQE IIGLAEVRDV FKSPKLGAIA GCMVTEGLIK RNAPIRVLRD 850
NVVIYEGELE SLRRFKDDVA EVKNGYECGI GVKNYNDVRV GDQIEVFETI 900
EIKRTID 907
Length:907
Mass (Da):99,590
Last modified:March 1, 2003 - v1
Checksum:iEDBEDE3C24F8705D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016795 Genomic DNA. Translation: AAO10112.1.
RefSeqiNP_760585.1. NC_004459.3.

Genome annotation databases

EnsemblBacteriaiAAO10112; AAO10112; VV1_1696.
GeneIDi1178611.
KEGGivvu:VV1_1696.
PATRICi20160183. VBIVibVul94426_1574.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016795 Genomic DNA. Translation: AAO10112.1 .
RefSeqi NP_760585.1. NC_004459.3.

3D structure databases

ProteinModelPortali Q8DBW0.
SMRi Q8DBW0. Positions 2-50.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 216895.VV1_1696.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO10112 ; AAO10112 ; VV1_1696 .
GeneIDi 1178611.
KEGGi vvu:VV1_1696.
PATRICi 20160183. VBIVibVul94426_1574.

Phylogenomic databases

eggNOGi COG0532.
HOGENOMi HOG000076907.
KOi K02519.
OMAi CTIDIDY.
OrthoDBi EOG67HJSV.

Enzyme and pathway databases

BioCyci VVUL216895:GIYM-1498-MONOMER.

Family and domain databases

Gene3Di 3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_00100_B. IF_2_B.
InterProi IPR009061. DNA-bd_dom_put.
IPR000795. EF_GTP-bd_dom.
IPR013575. IF2_assoc_dom_bac.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view ]
PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF08364. IF2_assoc. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view ]
SUPFAMi SSF46955. SSF46955. 1 hit.
SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Vibrio vulnificus CMCP6."
    Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E.
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CMCP6.

Entry informationi

Entry nameiIF2_VIBVU
AccessioniPrimary (citable) accession number: Q8DBW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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