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Q8DBW0

- IF2_VIBVU

UniProt

Q8DBW0 - IF2_VIBVU

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Protein

Translation initiation factor IF-2

Gene

infB

Organism
Vibrio vulnificus (strain CMCP6)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi415 – 4228GTPUniRule annotation
Nucleotide bindingi461 – 4655GTPUniRule annotation
Nucleotide bindingi515 – 5184GTPUniRule annotation

GO - Molecular functioni

  1. GTPase activity Source: UniProtKB-HAMAP
  2. GTP binding Source: UniProtKB-KW
  3. translation initiation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciVVUL216895:GIYM-1498-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2UniRule annotation
Gene namesi
Name:infBUniRule annotation
Ordered Locus Names:VV1_1696
OrganismiVibrio vulnificus (strain CMCP6)
Taxonomic identifieri216895 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000002275: Chromosome 1

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 907907Translation initiation factor IF-2PRO_0000137281Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi216895.VV1_1696.

Structurei

3D structure databases

ProteinModelPortaliQ8DBW0.
SMRiQ8DBW0. Positions 2-50.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini406 – 575170tr-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni415 – 4228G1By similarity
Regioni440 – 4445G2By similarity
Regioni461 – 4644G3By similarity
Regioni515 – 5184G4By similarity
Regioni551 – 5533G5By similarity

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0532.
HOGENOMiHOG000076907.
KOiK02519.
OMAiCTIDIDY.
OrthoDBiEOG67HJSV.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B.
InterProiIPR009061. DNA-bd_dom_put.
IPR000795. EF_GTP-bd_dom.
IPR013575. IF2_assoc_dom_bac.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF08364. IF2_assoc. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8DBW0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTQLTVKALS EEIGTPVDRL LEQLADAGMK KSSSDQVSDE EKQKLLTHLK
60 70 80 90 100
KEHGDTSGDA EPTRLTLQRK TRSTLSVNAG GGKSKDVQIE VRKKRTYVKR
110 120 130 140 150
SAIEDEAKRE AEEAAQREAE EAAKRAAEEA AKREAEEAAK REAEEKAKRE
160 170 180 190 200
AEEAAKREAE KSVDRDAEEK AKRDAEGKAK RDAEEKVKQE AARKEAEELK
210 220 230 240 250
RRQEEEAKRK AEEESQRKLE EAREMAEKNK ERWSAAEENK GDMEDTDYHV
260 270 280 290 300
TTSQYAREAE DEADRKEEEA RRRKKKTKSS AKASENDERG GPRVQRGGKG
310 320 330 340 350
GRKGKLSKPK SMQHGFDKSA VVAKSDVVIG ETIVVSELAN KMSVKATEVI
360 370 380 390 400
KIMMKMGAMA TINQVIDQET AQLVAEEMGH KVVLRKENEL EEAVLSDRDN
410 420 430 440 450
MFEAVPRAPV VTIMGHVDHG KTSTLDYIRR THVASGEAGG ITQHIGAYHV
460 470 480 490 500
ETENGMITFL DTPGHAAFTA MRARGAQATD IVVLVVAADD GVMPQTVEAI
510 520 530 540 550
QHAKAAGVPL IVAVNKIDKE EANPDNVKNE LSQYNVMPEE WGGENMFVHI
560 570 580 590 600
SAKQGTNIDQ LLETILLQAE VLELTAVKDG MASGVVVESR LDKGRGPVAT
610 620 630 640 650
VLVQSGTLRK GDIVLCGQEY GRVRAMRDEI GNEVNEAGPS IPVEILGLSG
660 670 680 690 700
VPAAGDEATV VRDERKAREV ANYRAGKFRE VKLARQQKSK LENMFSNMAA
710 720 730 740 750
GDVAELNIVL KADVQGSVEA IADSLTKLST EEVKVNIVGS GVGGITETDA
760 770 780 790 800
VLAEASNAII LGFNVRADAS ARRAIEAASI DLRYYSIIYQ LIDEVKQAMS
810 820 830 840 850
GMLAPEFKQE IIGLAEVRDV FKSPKLGAIA GCMVTEGLIK RNAPIRVLRD
860 870 880 890 900
NVVIYEGELE SLRRFKDDVA EVKNGYECGI GVKNYNDVRV GDQIEVFETI

EIKRTID
Length:907
Mass (Da):99,590
Last modified:March 1, 2003 - v1
Checksum:iEDBEDE3C24F8705D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016795 Genomic DNA. Translation: AAO10112.1.
RefSeqiNP_760585.1. NC_004459.3.

Genome annotation databases

EnsemblBacteriaiAAO10112; AAO10112; VV1_1696.
GeneIDi1178611.
KEGGivvu:VV1_1696.
PATRICi20160183. VBIVibVul94426_1574.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016795 Genomic DNA. Translation: AAO10112.1 .
RefSeqi NP_760585.1. NC_004459.3.

3D structure databases

ProteinModelPortali Q8DBW0.
SMRi Q8DBW0. Positions 2-50.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 216895.VV1_1696.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO10112 ; AAO10112 ; VV1_1696 .
GeneIDi 1178611.
KEGGi vvu:VV1_1696.
PATRICi 20160183. VBIVibVul94426_1574.

Phylogenomic databases

eggNOGi COG0532.
HOGENOMi HOG000076907.
KOi K02519.
OMAi CTIDIDY.
OrthoDBi EOG67HJSV.

Enzyme and pathway databases

BioCyci VVUL216895:GIYM-1498-MONOMER.

Family and domain databases

Gene3Di 3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_00100_B. IF_2_B.
InterProi IPR009061. DNA-bd_dom_put.
IPR000795. EF_GTP-bd_dom.
IPR013575. IF2_assoc_dom_bac.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view ]
PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF08364. IF2_assoc. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view ]
SUPFAMi SSF46955. SSF46955. 1 hit.
SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Vibrio vulnificus CMCP6."
    Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E.
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CMCP6.

Entry informationi

Entry nameiIF2_VIBVU
AccessioniPrimary (citable) accession number: Q8DBW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: March 1, 2003
Last modified: November 26, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3