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Protein

Lipid A export ATP-binding/permease protein MsbA

Gene

msbA

Organism
Vibrio vulnificus (strain CMCP6)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi376 – 383ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processLipid transport, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid A export ATP-binding/permease protein MsbAUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:msbAUniRule annotation
Ordered Locus Names:VV1_2085
OrganismiVibrio vulnificus (strain CMCP6)
Taxonomic identifieri216895 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Subcellular locationi

Q8DAV2:
  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei27 – 47HelicalUniRule annotationAdd BLAST21
Transmembranei69 – 89HelicalUniRule annotationAdd BLAST21
Transmembranei142 – 162HelicalUniRule annotationAdd BLAST21
Transmembranei165 – 185HelicalUniRule annotationAdd BLAST21
Transmembranei249 – 269HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000926031 – 583Lipid A export ATP-binding/permease protein MsbAAdd BLAST583

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ8DAV2.
SMRiQ8DAV2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 310ABC transmembrane type-1UniRule annotationAdd BLAST284
Domaini342 – 578ABC transporterUniRule annotationAdd BLAST237

Domaini

In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ1. Bacteria.
COG1132. LUCA.
KOiK11085.
OMAiSPLMEFL.
OrthoDBiPOG091H00DB.

Family and domain databases

Gene3Di1.20.1560.10. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR036640. ABC1_TM_sf.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR011917. ABC_transpr_lipidA.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR02203. MsbA_lipidA. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51239. MSBA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8DAV2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSINTDESTW RTFKRLWTFI RLYKSGLAVA VVALIINAVS DTYMVSLLKP
60 70 80 90 100
LLDEGFGSAE SDFLRTLPLL VFGLMFIRGI SSFVSTYCLS WVSGNVVMQV
110 120 130 140 150
RRMVFNHYMQ MPVSYFDKEK SGSLLSRITY DSEQVSAATS QALVSIVREG
160 170 180 190 200
TSIIGLLVLM FYNSWQLSLV LILVAPVVAW AIGFVSKRFR KISKNMQTTM
210 220 230 240 250
GIVTSSAEQM LKGHKVVLSY GGQEVEKSRF DVVSNQMRQQ SMKLITAQAA
260 270 280 290 300
ANPIIQMIAS IAIVVVLYLA SVDTIKDQLT PGTFTVVFSA MFGLMRPLKA
310 320 330 340 350
LTNVTSQFQR GMAAAQTLFA LVDLEPEKNT GTYSVERAKG EVNVKDISFT
360 370 380 390 400
YEGAEKPALS HVSFDIPRGK TVALVGRSGS GKSTIANLFT RFYDVDSGEI
410 420 430 440 450
QLDGVDVRDY ELKNLRTQFA LVSQNVHLFN DTIANNIAYA AGDKYSREDI
460 470 480 490 500
ERAAELAHAM EFISKMENGL DTMVGENGAS LSGGQRQRVA IARALLRDAP
510 520 530 540 550
VLILDEATSA LDTESERAIQ SALDELQKNK TVLVIAHRLS TIEKADQILV
560 570 580
IDDGSVVERG SHSELIEKDG AYAQLHRIQF GEG
Length:583
Mass (Da):64,255
Last modified:March 1, 2003 - v1
Checksum:i98C480C776C83DF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016795 Genomic DNA. Translation: AAO10473.1.
RefSeqiWP_011079971.1. NC_004459.3.

Genome annotation databases

EnsemblBacteriaiAAO10473; AAO10473; VV1_2085.
KEGGivvu:VV1_2085.

Similar proteinsi

Entry informationi

Entry nameiMSBA_VIBVU
AccessioniPrimary (citable) accession number: Q8DAV2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2003
Last modified: October 25, 2017
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families