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Q8DA54 (SPEA_VIBVU) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Biosynthetic arginine decarboxylase

Short name=ADC
EC=4.1.1.19
Gene names
Name:speA
Ordered Locus Names:VV1_2356
OrganismVibrio vulnificus (strain CMCP6) [Complete proteome] [HAMAP]
Taxonomic identifier216895 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length640 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the biosynthesis of agmatine from arginine By similarity. HAMAP-Rule MF_01417

Catalytic activity

L-arginine = agmatine + CO2. HAMAP-Rule MF_01417

Cofactor

Magnesium By similarity. HAMAP-Rule MF_01417

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01417

Sequence similarities

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 640640Biosynthetic arginine decarboxylase HAMAP-Rule MF_01417
PRO_0000149985

Regions

Region290 – 30011Substrate-binding Potential

Amino acid modifications

Modified residue1051N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8DA54 [UniParc].

Last modified July 27, 2011. Version 3.
Checksum: 3157EA5825FFF912

FASTA64072,493
        10         20         30         40         50         60 
MRLDVEQTSK LDRVRADYNV HYWSQGFYGI DDQGEMYVSP RSDNAHQIQL SKIVKQLEER 

        70         80         90        100        110        120 
QLNVPVLVRF PQILHQRVHS ICDAFNQAIE EYQYPNKYLL VYPIKVNQQR EVVDEILASQ 

       130        140        150        160        170        180 
AQLETKQLGL EAGSKPELLA VLAMAQHASS VIVCNGYKDR EYIRLALIGE KLGHKVFIVL 

       190        200        210        220        230        240 
EKMSELDLVL REAKSLGVTP RLGIRIRLAS QGAGKWQASG GEKSKFGLSA SQVLNVISRL 

       250        260        270        280        290        300 
KKENQLDTLQ LVHFHLGSQM ANIRDVRNGV NESARFYCEL RTLGANITYF DVGGGLAIDY 

       310        320        330        340        350        360 
DGTRSQSSNS MNYGLVEYAR NIVNTVGDVC KDYKQPMPVI ISESGRSLTA HHAVLISNVI 

       370        380        390        400        410        420 
GTETYKPETV TEPEEDFPLL LNNMWRSWLN LHNGTDARAL IEIYNDTQSD LAEVHSQFAT 

       430        440        450        460        470        480 
GVLTLEHRAW AEQTSLRIYY ELNRLMSTKN RFHRPILDEL SERLADKFFV NFSLFQSLPD 

       490        500        510        520        530        540 
SWGIDQVFPV LPLSGLQNAA DRRAVMLDIT CDSDGAIDAY VDGQGIESTL PVPAWNEDEP 

       550        560        570        580        590        600 
YLMGFFLVGA YQEILGDMHN LFGDTHSVVV NVGDQGEINI DFINEGDTVE DMMRYVHIDV 

       610        620        630        640 
DQIRKNYHSL VSQRVDQEEQ QQILAELEQG LSGYTYLEDF 

« Hide

References

« Hide 'large scale' references
[1]"Complete genome sequence of Vibrio vulnificus CMCP6."
Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E.
Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CMCP6.
[2]"Integrative genome-scale metabolic analysis of Vibrio vulnificus for drug targeting and discovery."
Kim H.U., Kim S.Y., Jeong H., Kim T.Y., Kim J.J., Choy H.E., Yi K.Y., Rhee J.H., Lee S.Y.
Mol. Syst. Biol. 7:460-460(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016795 Genomic DNA. Translation: AAO10730.2.
RefSeqNP_761203.2. NC_004459.3.

3D structure databases

ProteinModelPortalQ8DA54.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING216895.VV1_2356.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO10730; AAO10730; VV1_2356.
GeneID1179231.
KEGGvvu:VV1_2356.
PATRIC20161485. VBIVibVul94426_2221.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1166.
HOGENOMHOG000029191.
KOK01585.

Enzyme and pathway databases

BioCycVVUL216895:GIYM-2108-MONOMER.

Family and domain databases

Gene3D2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPMF_01417. SpeA.
InterProIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022644. De-COase2_N.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMSSF51419. SSF51419. 1 hit.
TIGRFAMsTIGR01273. speA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSPEA_VIBVU
AccessionPrimary (citable) accession number: Q8DA54
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: July 27, 2011
Last modified: June 11, 2014
This is version 74 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families