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Q8DA54

- SPEA_VIBVU

UniProt

Q8DA54 - SPEA_VIBVU

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Protein

Biosynthetic arginine decarboxylase

Gene

speA

Organism
Vibrio vulnificus (strain CMCP6)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the biosynthesis of agmatine from arginine.UniRule annotation

Catalytic activityi

L-arginine = agmatine + CO2.UniRule annotation

Cofactori

Magnesium.UniRule annotation
Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. arginine decarboxylase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. arginine catabolic process Source: InterPro
  2. spermidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Polyamine biosynthesis, Spermidine biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding, Pyridoxal phosphate

Enzyme and pathway databases

BioCyciVVUL216895:GIYM-2108-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Biosynthetic arginine decarboxylaseUniRule annotation (EC:4.1.1.19UniRule annotation)
Short name:
ADCUniRule annotation
Gene namesi
Name:speAUniRule annotation
Ordered Locus Names:VV1_2356
OrganismiVibrio vulnificus (strain CMCP6)
Taxonomic identifieri216895 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000002275: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 640640Biosynthetic arginine decarboxylasePRO_0000149985Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei105 – 1051N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi216895.VV1_2356.

Structurei

3D structure databases

ProteinModelPortaliQ8DA54.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni290 – 30011Substrate-bindingUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1166.
HOGENOMiHOG000029191.
KOiK01585.

Family and domain databases

Gene3Di2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPiMF_01417. SpeA.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022644. De-COase2_N.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSiPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMiSSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01273. speA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8DA54-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRLDVEQTSK LDRVRADYNV HYWSQGFYGI DDQGEMYVSP RSDNAHQIQL
60 70 80 90 100
SKIVKQLEER QLNVPVLVRF PQILHQRVHS ICDAFNQAIE EYQYPNKYLL
110 120 130 140 150
VYPIKVNQQR EVVDEILASQ AQLETKQLGL EAGSKPELLA VLAMAQHASS
160 170 180 190 200
VIVCNGYKDR EYIRLALIGE KLGHKVFIVL EKMSELDLVL REAKSLGVTP
210 220 230 240 250
RLGIRIRLAS QGAGKWQASG GEKSKFGLSA SQVLNVISRL KKENQLDTLQ
260 270 280 290 300
LVHFHLGSQM ANIRDVRNGV NESARFYCEL RTLGANITYF DVGGGLAIDY
310 320 330 340 350
DGTRSQSSNS MNYGLVEYAR NIVNTVGDVC KDYKQPMPVI ISESGRSLTA
360 370 380 390 400
HHAVLISNVI GTETYKPETV TEPEEDFPLL LNNMWRSWLN LHNGTDARAL
410 420 430 440 450
IEIYNDTQSD LAEVHSQFAT GVLTLEHRAW AEQTSLRIYY ELNRLMSTKN
460 470 480 490 500
RFHRPILDEL SERLADKFFV NFSLFQSLPD SWGIDQVFPV LPLSGLQNAA
510 520 530 540 550
DRRAVMLDIT CDSDGAIDAY VDGQGIESTL PVPAWNEDEP YLMGFFLVGA
560 570 580 590 600
YQEILGDMHN LFGDTHSVVV NVGDQGEINI DFINEGDTVE DMMRYVHIDV
610 620 630 640
DQIRKNYHSL VSQRVDQEEQ QQILAELEQG LSGYTYLEDF
Length:640
Mass (Da):72,493
Last modified:July 27, 2011 - v3
Checksum:i3157EA5825FFF912
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016795 Genomic DNA. Translation: AAO10730.2.
RefSeqiNP_761203.2. NC_004459.3.
WP_011080224.1. NC_004459.3.

Genome annotation databases

EnsemblBacteriaiAAO10730; AAO10730; VV1_2356.
GeneIDi1179231.
KEGGivvu:VV1_2356.
PATRICi20161485. VBIVibVul94426_2221.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016795 Genomic DNA. Translation: AAO10730.2 .
RefSeqi NP_761203.2. NC_004459.3.
WP_011080224.1. NC_004459.3.

3D structure databases

ProteinModelPortali Q8DA54.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 216895.VV1_2356.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO10730 ; AAO10730 ; VV1_2356 .
GeneIDi 1179231.
KEGGi vvu:VV1_2356.
PATRICi 20161485. VBIVibVul94426_2221.

Phylogenomic databases

eggNOGi COG1166.
HOGENOMi HOG000029191.
KOi K01585.

Enzyme and pathway databases

BioCyci VVUL216895:GIYM-2108-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPi MF_01417. SpeA.
InterProi IPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022644. De-COase2_N.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view ]
PIRSFi PIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSi PR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMi SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR01273. speA. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete genome sequence of Vibrio vulnificus CMCP6."
    Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E.
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CMCP6.
  2. "Integrative genome-scale metabolic analysis of Vibrio vulnificus for drug targeting and discovery."
    Kim H.U., Kim S.Y., Jeong H., Kim T.Y., Kim J.J., Choy H.E., Yi K.Y., Rhee J.H., Lee S.Y.
    Mol. Syst. Biol. 7:460-460(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.

Entry informationi

Entry nameiSPEA_VIBVU
AccessioniPrimary (citable) accession number: Q8DA54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 76 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3