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Q8D9M7

- NAGK_VIBVU

UniProt

Q8D9M7 - NAGK_VIBVU

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Protein

N-acetyl-D-glucosamine kinase

Gene

nagK

Organism
Vibrio vulnificus (strain CMCP6)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P.UniRule annotation

Catalytic activityi

ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi157 – 1571ZincUniRule annotation
Metal bindingi177 – 1771ZincUniRule annotation
Metal bindingi179 – 1791ZincUniRule annotation
Metal bindingi184 – 1841ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi4 – 118ATPUniRule annotation
Nucleotide bindingi133 – 1408ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. N-acetylglucosamine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. N-acetylglucosamine metabolic process Source: UniProtKB-HAMAP
  2. peptidoglycan turnover Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciVVUL216895:GIYM-2320-MONOMER.
UniPathwayiUPA00544.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetyl-D-glucosamine kinaseUniRule annotation (EC:2.7.1.59UniRule annotation)
Alternative name(s):
GlcNAc kinaseUniRule annotation
Gene namesi
Name:nagKUniRule annotation
Ordered Locus Names:VV1_2570
OrganismiVibrio vulnificus (strain CMCP6)
Taxonomic identifieri216895 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000002275: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 303303N-acetyl-D-glucosamine kinasePRO_0000270122Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi216895.VV1_2570.

Structurei

Secondary structure

1
303
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 76
Beta strandi9 – 179
Beta strandi23 – 308
Helixi36 – 5419
Beta strandi59 – 6810
Turni70 – 723
Beta strandi75 – 806
Helixi81 – 833
Helixi88 – 969
Beta strandi101 – 1044
Helixi105 – 11410
Turni117 – 1215
Beta strandi123 – 14018
Helixi155 – 1573
Helixi162 – 1676
Beta strandi182 – 1843
Helixi185 – 1873
Helixi191 – 20212
Helixi208 – 21710
Helixi220 – 24425
Beta strandi247 – 2537
Helixi254 – 2574
Helixi260 – 2689
Helixi269 – 2724
Beta strandi281 – 2844
Helixi288 – 2903
Helixi291 – 2988

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4DB3X-ray1.95A1-303[»]
ProteinModelPortaliQ8D9M7.
SMRiQ8D9M7. Positions 1-302.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ROK (NagC/XylR) family. NagK subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1940.
HOGENOMiHOG000150087.
KOiK00884.

Family and domain databases

HAMAPiMF_01271. GlcNAc_kinase.
InterProiIPR023505. N-acetyl-D-glucosamine_kinase.
IPR000600. ROK.
[Graphical view]
PfamiPF00480. ROK. 1 hit.
[Graphical view]
PROSITEiPS01125. ROK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8D9M7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYYGFDVGGT KIEFGAFNEK LERVATERVP TPTDDYPLLL ETIAGLVAKY
60 70 80 90 100
DQEFACEGKI GLGLPGMEDA DDATVLTVNV PAAKGKPLRA DLEAKIGRSV
110 120 130 140 150
KIENDANCFA LSEAWDEELQ DAPSVMGLIL GTGFGGGLIY EGKVFSGRNN
160 170 180 190 200
VAGELGHMRL PLDAWFHLGD NAPLLGCGCG KKGCLDSYLS GRGFELLYAH
210 220 230 240 250
YYGEEKKAID IIKANAAGDE KAAEHVERFM ELLAICFGNI FTANDPHVVA
260 270 280 290 300
LGGGLSNFEL IYEEMPKRVP KYLLSVAKCP KIIKAKHGDS GGVRGAAFLN

IKG
Length:303
Mass (Da):32,570
Last modified:July 27, 2011 - v2
Checksum:iF1804F008B123B61
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016795 Genomic DNA. Translation: AAO10921.2.
RefSeqiNP_761394.2. NC_004459.3.
WP_011080420.1. NC_004459.3.

Genome annotation databases

EnsemblBacteriaiAAO10921; AAO10921; VV1_2570.
GeneIDi1179422.
KEGGivvu:VV1_2570.
PATRICi20162134. VBIVibVul94426_2545.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016795 Genomic DNA. Translation: AAO10921.2 .
RefSeqi NP_761394.2. NC_004459.3.
WP_011080420.1. NC_004459.3.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4DB3 X-ray 1.95 A 1-303 [» ]
ProteinModelPortali Q8D9M7.
SMRi Q8D9M7. Positions 1-302.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 216895.VV1_2570.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO10921 ; AAO10921 ; VV1_2570 .
GeneIDi 1179422.
KEGGi vvu:VV1_2570.
PATRICi 20162134. VBIVibVul94426_2545.

Phylogenomic databases

eggNOGi COG1940.
HOGENOMi HOG000150087.
KOi K00884.

Enzyme and pathway databases

UniPathwayi UPA00544 .
BioCyci VVUL216895:GIYM-2320-MONOMER.

Family and domain databases

HAMAPi MF_01271. GlcNAc_kinase.
InterProi IPR023505. N-acetyl-D-glucosamine_kinase.
IPR000600. ROK.
[Graphical view ]
Pfami PF00480. ROK. 1 hit.
[Graphical view ]
PROSITEi PS01125. ROK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete genome sequence of Vibrio vulnificus CMCP6."
    Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E.
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CMCP6.
  2. "Integrative genome-scale metabolic analysis of Vibrio vulnificus for drug targeting and discovery."
    Kim H.U., Kim S.Y., Jeong H., Kim T.Y., Kim J.J., Choy H.E., Yi K.Y., Rhee J.H., Lee S.Y.
    Mol. Syst. Biol. 7:460-460(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION TO 297.

Entry informationi

Entry nameiNAGK_VIBVU
AccessioniPrimary (citable) accession number: Q8D9M7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3