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Q8D9M7

- NAGK_VIBVU

UniProt

Q8D9M7 - NAGK_VIBVU

Protein

N-acetyl-D-glucosamine kinase

Gene

nagK

Organism
Vibrio vulnificus (strain CMCP6)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P.UniRule annotation

    Catalytic activityi

    ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi157 – 1571ZincUniRule annotation
    Metal bindingi177 – 1771ZincUniRule annotation
    Metal bindingi179 – 1791ZincUniRule annotation
    Metal bindingi184 – 1841ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi4 – 118ATPUniRule annotation
    Nucleotide bindingi133 – 1408ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. N-acetylglucosamine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. N-acetylglucosamine metabolic process Source: UniProtKB-HAMAP
    2. peptidoglycan turnover Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Carbohydrate metabolism

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciVVUL216895:GIYM-2320-MONOMER.
    UniPathwayiUPA00544.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-acetyl-D-glucosamine kinaseUniRule annotation (EC:2.7.1.59UniRule annotation)
    Alternative name(s):
    GlcNAc kinaseUniRule annotation
    Gene namesi
    Name:nagKUniRule annotation
    Ordered Locus Names:VV1_2570
    OrganismiVibrio vulnificus (strain CMCP6)
    Taxonomic identifieri216895 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000002275: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 303303N-acetyl-D-glucosamine kinasePRO_0000270122Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi216895.VV1_2570.

    Structurei

    Secondary structure

    1
    303
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi2 – 76
    Beta strandi9 – 179
    Beta strandi23 – 308
    Helixi36 – 5419
    Beta strandi59 – 6810
    Turni70 – 723
    Beta strandi75 – 806
    Helixi81 – 833
    Helixi88 – 969
    Beta strandi101 – 1044
    Helixi105 – 11410
    Turni117 – 1215
    Beta strandi123 – 14018
    Helixi155 – 1573
    Helixi162 – 1676
    Beta strandi182 – 1843
    Helixi185 – 1873
    Helixi191 – 20212
    Helixi208 – 21710
    Helixi220 – 24425
    Beta strandi247 – 2537
    Helixi254 – 2574
    Helixi260 – 2689
    Helixi269 – 2724
    Beta strandi281 – 2844
    Helixi288 – 2903
    Helixi291 – 2988

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4DB3X-ray1.95A1-303[»]
    ProteinModelPortaliQ8D9M7.
    SMRiQ8D9M7. Positions 1-302.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ROK (NagC/XylR) family. NagK subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1940.
    HOGENOMiHOG000150087.
    KOiK00884.

    Family and domain databases

    HAMAPiMF_01271. GlcNAc_kinase.
    InterProiIPR023505. N-acetyl-D-glucosamine_kinase.
    IPR000600. ROK.
    [Graphical view]
    PfamiPF00480. ROK. 1 hit.
    [Graphical view]
    PROSITEiPS01125. ROK. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8D9M7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYYGFDVGGT KIEFGAFNEK LERVATERVP TPTDDYPLLL ETIAGLVAKY    50
    DQEFACEGKI GLGLPGMEDA DDATVLTVNV PAAKGKPLRA DLEAKIGRSV 100
    KIENDANCFA LSEAWDEELQ DAPSVMGLIL GTGFGGGLIY EGKVFSGRNN 150
    VAGELGHMRL PLDAWFHLGD NAPLLGCGCG KKGCLDSYLS GRGFELLYAH 200
    YYGEEKKAID IIKANAAGDE KAAEHVERFM ELLAICFGNI FTANDPHVVA 250
    LGGGLSNFEL IYEEMPKRVP KYLLSVAKCP KIIKAKHGDS GGVRGAAFLN 300
    IKG 303
    Length:303
    Mass (Da):32,570
    Last modified:July 27, 2011 - v2
    Checksum:iF1804F008B123B61
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016795 Genomic DNA. Translation: AAO10921.2.
    RefSeqiNP_761394.2. NC_004459.3.

    Genome annotation databases

    EnsemblBacteriaiAAO10921; AAO10921; VV1_2570.
    GeneIDi1179422.
    KEGGivvu:VV1_2570.
    PATRICi20162134. VBIVibVul94426_2545.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016795 Genomic DNA. Translation: AAO10921.2 .
    RefSeqi NP_761394.2. NC_004459.3.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4DB3 X-ray 1.95 A 1-303 [» ]
    ProteinModelPortali Q8D9M7.
    SMRi Q8D9M7. Positions 1-302.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 216895.VV1_2570.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO10921 ; AAO10921 ; VV1_2570 .
    GeneIDi 1179422.
    KEGGi vvu:VV1_2570.
    PATRICi 20162134. VBIVibVul94426_2545.

    Phylogenomic databases

    eggNOGi COG1940.
    HOGENOMi HOG000150087.
    KOi K00884.

    Enzyme and pathway databases

    UniPathwayi UPA00544 .
    BioCyci VVUL216895:GIYM-2320-MONOMER.

    Family and domain databases

    HAMAPi MF_01271. GlcNAc_kinase.
    InterProi IPR023505. N-acetyl-D-glucosamine_kinase.
    IPR000600. ROK.
    [Graphical view ]
    Pfami PF00480. ROK. 1 hit.
    [Graphical view ]
    PROSITEi PS01125. ROK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Vibrio vulnificus CMCP6."
      Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E.
      Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CMCP6.
    2. "Integrative genome-scale metabolic analysis of Vibrio vulnificus for drug targeting and discovery."
      Kim H.U., Kim S.Y., Jeong H., Kim T.Y., Kim J.J., Choy H.E., Yi K.Y., Rhee J.H., Lee S.Y.
      Mol. Syst. Biol. 7:460-460(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION TO 297.

    Entry informationi

    Entry nameiNAGK_VIBVU
    AccessioniPrimary (citable) accession number: Q8D9M7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 65 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3