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Protein

Catalase-peroxidase

Gene

katG

Organism
Vibrio vulnificus (strain CMCP6)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei95 – 951Transition state stabilizerUniRule annotation
Active sitei99 – 991Proton acceptorUniRule annotation
Metal bindingi267 – 2671Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciVVUL216895:GIYM-2493-MONOMER.

Protein family/group databases

PeroxiBasei2651. VvuCP_CMPCP6.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:VV1_2755
OrganismiVibrio vulnificus (strain CMCP6)
Taxonomic identifieri216895 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 723723Catalase-peroxidasePRO_0000354952Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki98 ↔ 226Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-252)UniRule annotation
Cross-linki226 ↔ 252Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-98)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiQ8D951.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi216895.VV1_2755.

Structurei

3D structure databases

ProteinModelPortaliQ8D951.
SMRiQ8D951. Positions 25-723.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiQPEEMML.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8D951-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHKPTHTSG QCPVMHGGAT SSNSSNVAWW PKALNLDILH QHDRKSNPMG
60 70 80 90 100
ADFSYREELK KLDVEALKRD LKTLMTDSQD WWPADWGHYG GLMIRMAWHS
110 120 130 140 150
AGSYRVGDGR GGADTGNQRF APLNSWPDNA NLDKARRLLW PIKQKYGNKI
160 170 180 190 200
SWADLMILAG NMAYESMGLK TFGFAFGRED IWHPEKDIYW GAEQEWLAPS
210 220 230 240 250
GAENSRYSGE RDLENPLAAV MMGLIYVNPE GVDGNPDPLK TAKDMRVTFA
260 270 280 290 300
RMGMNDEETV ALTAGGHTVG KAHGNGNAAN LGADPESADL EEQGLGWNNH
310 320 330 340 350
KSRGIGRDTV TSGIEGAWTT NPTQWDNGFF HLLFSYDWWL QKSPAGAWQW
360 370 380 390 400
EPVNIKEEDK PVDVEDPTIR HNPIMTDADM ALKLDPEYRK ISERFHKDPA
410 420 430 440 450
YFSETFARAW FKLTHRDMGP KARYFGPDVP AETLIWQDPV PTGRKDYDVD
460 470 480 490 500
AVKAKIIASG LSIGEMVSTA WDSARTFRNS DKRGGANGAR IRLAPQKDWL
510 520 530 540 550
GNEPEKLAKV LNVLEAIASE FNISVADTIV LAGNVGVEQA AKAAGIAITV
560 570 580 590 600
PFAAGRGDAT IEQTDVESFD VLEPIADGFR NWQKQHYAVN PEELLLDRAQ
610 620 630 640 650
LLGLSAPEMT VLIGGLRVLG TNHGGTKHGV FTDNVGALSN DFFVNLTDMR
660 670 680 690 700
YTWKPTGRNS YDIVERNSGN VKWTATRVDL VFGSNSILRA YAEVYAQDDN
710 720
KEKFVKDFVA AWTKVMNADR FDI
Length:723
Mass (Da):80,425
Last modified:March 1, 2003 - v1
Checksum:iD714DD48FD7073FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016795 Genomic DNA. Translation: AAO11099.1.
RefSeqiWP_011080593.1. NC_004459.3.

Genome annotation databases

EnsemblBacteriaiAAO11099; AAO11099; VV1_2755.
KEGGivvu:VV1_2755.
PATRICi20162497. VBIVibVul94426_2726.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016795 Genomic DNA. Translation: AAO11099.1.
RefSeqiWP_011080593.1. NC_004459.3.

3D structure databases

ProteinModelPortaliQ8D951.
SMRiQ8D951. Positions 25-723.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi216895.VV1_2755.

Protein family/group databases

PeroxiBasei2651. VvuCP_CMPCP6.

Proteomic databases

PRIDEiQ8D951.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO11099; AAO11099; VV1_2755.
KEGGivvu:VV1_2755.
PATRICi20162497. VBIVibVul94426_2726.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiQPEEMML.
OrthoDBiPOG091H05R1.

Enzyme and pathway databases

BioCyciVVUL216895:GIYM-2493-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_VIBVU
AccessioniPrimary (citable) accession number: Q8D951
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.