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Protein

Ribosomal RNA large subunit methyltransferase F

Gene

rlmF

Organism
Vibrio vulnificus (strain CMCP6)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Specifically methylates the adenine in position 1618 of 23S rRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + adenine(1618) in 23S rRNA = S-adenosyl-L-homocysteine + rRNA containing N(6)-methyladenine(1618) in 23S rRNA.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciVVUL216895:GIYM-2510-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA large subunit methyltransferase FUniRule annotation (EC:2.1.1.181UniRule annotation)
Alternative name(s):
23S rRNA mA1618 methyltransferaseUniRule annotation
rRNA adenine N-6-methyltransferaseUniRule annotation
Gene namesi
Name:rlmFUniRule annotation
Ordered Locus Names:VV1_2774
OrganismiVibrio vulnificus (strain CMCP6)
Taxonomic identifieri216895 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 364364Ribosomal RNA large subunit methyltransferase FPRO_0000349978Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi216895.VV1_2774.

Structurei

3D structure databases

ProteinModelPortaliQ8D935.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily. METTL16/RlmF family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EBA. Bacteria.
COG3129. LUCA.
HOGENOMiHOG000218605.
KOiK06970.
OMAiVTLCNPP.
OrthoDBiPOG091H05H4.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01848. 23SrRNA_methyltr_F. 1 hit.
InterProiIPR016909. rRNA_lsu_MeTfrase_F.
IPR010286. rRNA_lsu_MeTfrase_F-like.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR13393. PTHR13393. 2 hits.
PfamiPF05971. Methyltransf_10. 1 hit.
[Graphical view]
PIRSFiPIRSF029038. Mtase_YbiN_prd. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8D935-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNKRKSAKP LEPAKRAPKP RTKKSRDLSA SESNCDFVKV TRAGLHSRNK
60 70 80 90 100
HQGRYDFAKL TQALPSLAPF VIKNPKGEAS ISFSDSTAVK MLNKALLSAY
110 120 130 140 150
YQVANWDIPA GYLCPPIPGR ADYIHRLAEL LEGEVKGKFP HEKVQALDIG
160 170 180 190 200
VGANAIYPII AICDYRWRYT GSDVDPKSIE SAQRIADSNP VLQGQLELKL
210 220 230 240 250
QDQSQHIFQG IIGPTDYFHV TTCNPPFHAS AQEAAFGTQR KLDNLAANRL
260 270 280 290 300
KKGVTAKAGS QKISKNKPIL NFGGQNSELW CQGGESSFLK RMANESERFA
310 320 330 340 350
HQVLWFSTLV SKKDNVRPLR KQLEKLGVRS IRVVEMSQGQ KVSRFVAWSF
360
MDKQQRGEWI KLRG
Length:364
Mass (Da):40,722
Last modified:March 1, 2003 - v1
Checksum:i75B257B095EFA6C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016795 Genomic DNA. Translation: AAO11116.1.
RefSeqiWP_011080610.1. NC_004459.3.

Genome annotation databases

EnsemblBacteriaiAAO11116; AAO11116; VV1_2774.
KEGGivvu:VV1_2774.
PATRICi20162538. VBIVibVul94426_2744.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016795 Genomic DNA. Translation: AAO11116.1.
RefSeqiWP_011080610.1. NC_004459.3.

3D structure databases

ProteinModelPortaliQ8D935.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi216895.VV1_2774.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO11116; AAO11116; VV1_2774.
KEGGivvu:VV1_2774.
PATRICi20162538. VBIVibVul94426_2744.

Phylogenomic databases

eggNOGiENOG4105EBA. Bacteria.
COG3129. LUCA.
HOGENOMiHOG000218605.
KOiK06970.
OMAiVTLCNPP.
OrthoDBiPOG091H05H4.

Enzyme and pathway databases

BioCyciVVUL216895:GIYM-2510-MONOMER.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01848. 23SrRNA_methyltr_F. 1 hit.
InterProiIPR016909. rRNA_lsu_MeTfrase_F.
IPR010286. rRNA_lsu_MeTfrase_F-like.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR13393. PTHR13393. 2 hits.
PfamiPF05971. Methyltransf_10. 1 hit.
[Graphical view]
PIRSFiPIRSF029038. Mtase_YbiN_prd. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRLMF_VIBVU
AccessioniPrimary (citable) accession number: Q8D935
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.