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Q8D915 (PUR7_VIBVU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
EC=6.3.2.6
Alternative name(s):
SAICAR synthetase
Gene names
Name:purC
Ordered Locus Names:VV1_2797
OrganismVibrio vulnificus [Complete proteome] [HAMAP]
Taxonomic identifier672 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length367 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. HAMAP MF_00137

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. HAMAP MF_00137

Sequence similarities

Belongs to the SAICAR synthetase family.

Ontologies

Keywords
   Biological processPurine biosynthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpurine nucleotide biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoribosylaminoimidazolesuccinocarboxamide synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 367367Phosphoribosylaminoimidazole-succinocarboxamide synthase HAMAP MF_00137
PRO_0000100897

Sequences

Sequence LengthMass (Da)Tools
Q8D915 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 14EF20EB7B9BFE9E

FASTA36740,817
        10         20         30         40         50         60 
MSLADQVLAV NDDLPIRTDK PVHSGKVRSV YWLTEEDSAR LIKEKGYNVA PDAPLAIMVI 

        70         80         90        100        110        120 
SDRISAFDCI WHGEHGLNGV PGKGAALNAI SNHWFGLFKE NGLADSHILD IPHPFVWIVQ 

       130        140        150        160        170        180 
KAKPVKIEAI CRKYITGSMW RAYEKGEREF CGIQLPEGLE KDKALPDLLM TPSTKGILKG 

       190        200        210        220        230        240 
IPGVPEADDV NITRQNIADN FAAFNFSSAD DIALYEKLLK DGFGVISEAL ANVGQIFVDT 

       250        260        270        280        290        300 
KFEFGYVTDA AGNEKLIYMD EVGTPDSSRI WDAQEYQAGK IVENSKEGFR QFLLNYFPDP 

       310        320        330        340        350        360 
DILLNKDRMP EREALARDNE LPEEALMAVS RTYINIAEKI TGSAIVLSDN PKQEIIDILG 


REYGLID

« Hide

References

[1]"Complete genome sequence of Vibrio vulnificus CMCP6."
Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E.
Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CMCP6.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE016795 Genomic DNA. Translation: AAO11136.1.
RefSeqNP_761609.1. NC_004459.3.

3D structure databases

ProteinModelPortalQ8D915.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1179639.
GenomeReviewsGene locus VV1_2797 in contig AE016795_GR.
KEGGvvu:VV1_2797.
PATRIC20162580. VBIVibVul94426_2765.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG555040.
OMASSRIWDG.
ProtClustDBPRK13960.

Enzyme and pathway databases

BioCycVVUL216895:VV1_2797-MONOMER.

Family and domain databases

HAMAPMF_00137. SAICAR_synth.
[Tree]
InterProIPR013816. ATP_grasp_subdomain_2.
IPR014106. PurC_vibrio.
IPR001636. SAICAR_synth.
IPR018236. SAICAR_synthetase_CS.
[Graphical view]
Gene3DG3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
KOK01923.
PANTHERPTHR11609. SAICAR_synt. 1 hit.
PfamPF01259. SAICAR_synt. 1 hit.
[Graphical view]
TIGRFAMsTIGR02735. PurC_vibrio. 1 hit.
PROSITEPS01057. SAICAR_SYNTHETASE_1. 1 hit.
PS01058. SAICAR_SYNTHETASE_2. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePUR7_VIBVU
AccessionPrimary (citable) accession number: Q8D915
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: March 1, 2003
Last modified: January 25, 2012
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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