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Q8D8P9

- HIS1_VIBVU

UniProt

Q8D8P9 - HIS1_VIBVU

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Protein

ATP phosphoribosyltransferase

Gene
hisG, VV1_2920
Organism
Vibrio vulnificus (strain CMCP6)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity By similarity.UniRule annotation

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Enzyme regulationi

Feedback inhibited by histidine By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATP phosphoribosyltransferase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciVVUL216895:GIYM-2640-MONOMER.
UniPathwayiUPA00031; UER00006.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP phosphoribosyltransferase (EC:2.4.2.17)
Short name:
ATP-PRT
Short name:
ATP-PRTase
Gene namesi
Name:hisG
Ordered Locus Names:VV1_2920
OrganismiVibrio vulnificus (strain CMCP6)
Taxonomic identifieri216895 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000002275: Chromosome 1

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 298298ATP phosphoribosyltransferaseUniRule annotationPRO_0000151871Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi216895.VV1_2920.

Structurei

3D structure databases

ProteinModelPortaliQ8D8P9.
SMRiQ8D8P9. Positions 5-298.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0040.
HOGENOMiHOG000223247.
KOiK00765.
OMAiTRMQGVI.
OrthoDBiEOG66MQT3.

Family and domain databases

Gene3Di3.30.70.120. 1 hit.
HAMAPiMF_00079. HisG_Long.
InterProiIPR013820. ATP_PRibTrfase_cat.
IPR018198. ATP_PRibTrfase_CS.
IPR001348. ATP_PRibTrfase_HisG.
IPR020621. ATP_PRibTrfase_HisG_long.
IPR013115. HisG_C.
IPR011322. N-reg_PII-like_a/b.
IPR015867. N-reg_PII/ATP_PRibTrfase_C.
[Graphical view]
PANTHERiPTHR21403. PTHR21403. 1 hit.
PfamiPF01634. HisG. 1 hit.
PF08029. HisG_C. 1 hit.
[Graphical view]
SUPFAMiSSF54913. SSF54913. 1 hit.
TIGRFAMsiTIGR00070. hisG. 1 hit.
TIGR03455. HisG_C-term. 1 hit.
PROSITEiPS01316. ATP_P_PHORIBOSYLTR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8D8P9-1 [UniParc]FASTAAdd to Basket

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MQTQRLRIAI QKKGRLSEEC QGLLKKCGVK FNIMGERLVV HSENMPIDLL    50
LVRDDDIPGL IMDGVVDLGF IGENVLEEVR LERKATGDAC QFETLSRLDF 100
GGCRLSIAID KDEKYNGPQD LAGKRIATTY PQLLKAYMDR QGVPFSTCML 150
TGSVEVAPRA GLADAIADLV STGATLEANG LKEAEVIFQS KATLIQRSGE 200
FAQDKQALIE KLLTRMQGVQ QAKESKYIML HAPVDKLEQI KALLPGAEDP 250
TVLPLSAEKQ RVAVHLVSTE NLFWETMEQL KELGASSILV LPIEKMME 298
Length:298
Mass (Da):32,911
Last modified:April 30, 2003 - v2
Checksum:i3B3B975B9CE8B5E7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016795 Genomic DNA. Translation: AAO11253.2.
RefSeqiNP_761726.2. NC_004459.3.

Genome annotation databases

EnsemblBacteriaiAAO11253; AAO11253; VV1_2920.
GeneIDi1179756.
KEGGivvu:VV1_2920.
PATRICi20162817. VBIVibVul94426_2883.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016795 Genomic DNA. Translation: AAO11253.2 .
RefSeqi NP_761726.2. NC_004459.3.

3D structure databases

ProteinModelPortali Q8D8P9.
SMRi Q8D8P9. Positions 5-298.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 216895.VV1_2920.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO11253 ; AAO11253 ; VV1_2920 .
GeneIDi 1179756.
KEGGi vvu:VV1_2920.
PATRICi 20162817. VBIVibVul94426_2883.

Phylogenomic databases

eggNOGi COG0040.
HOGENOMi HOG000223247.
KOi K00765.
OMAi TRMQGVI.
OrthoDBi EOG66MQT3.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00006 .
BioCyci VVUL216895:GIYM-2640-MONOMER.

Family and domain databases

Gene3Di 3.30.70.120. 1 hit.
HAMAPi MF_00079. HisG_Long.
InterProi IPR013820. ATP_PRibTrfase_cat.
IPR018198. ATP_PRibTrfase_CS.
IPR001348. ATP_PRibTrfase_HisG.
IPR020621. ATP_PRibTrfase_HisG_long.
IPR013115. HisG_C.
IPR011322. N-reg_PII-like_a/b.
IPR015867. N-reg_PII/ATP_PRibTrfase_C.
[Graphical view ]
PANTHERi PTHR21403. PTHR21403. 1 hit.
Pfami PF01634. HisG. 1 hit.
PF08029. HisG_C. 1 hit.
[Graphical view ]
SUPFAMi SSF54913. SSF54913. 1 hit.
TIGRFAMsi TIGR00070. hisG. 1 hit.
TIGR03455. HisG_C-term. 1 hit.
PROSITEi PS01316. ATP_P_PHORIBOSYLTR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Vibrio vulnificus CMCP6."
    Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E.
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CMCP6.

Entry informationi

Entry nameiHIS1_VIBVU
AccessioniPrimary (citable) accession number: Q8D8P9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: April 30, 2003
Last modified: June 11, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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