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Protein

Ubiquinone biosynthesis O-methyltransferase

Gene

ubiG

Organism
Vibrio vulnificus (strain CMCP6)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + 3-demethylubiquinone-n = S-adenosyl-L-homocysteine + ubiquinone-n.UniRule annotation
S-adenosyl-L-methionine + 3-(all-trans-polyprenyl)benzene-1,2-diol = S-adenosyl-L-homocysteine + 2-methoxy-6-(all-trans-polyprenyl)phenol.UniRule annotation

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391S-adenosyl-L-methionineUniRule annotation
Binding sitei59 – 591S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
Binding sitei80 – 801S-adenosyl-L-methionineUniRule annotation
Binding sitei124 – 1241S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Ubiquinone biosynthesis

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciVVUL216895:GIYM-2745-MONOMER.
UniPathwayiUPA00232.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquinone biosynthesis O-methyltransferaseUniRule annotation
Alternative name(s):
2-polyprenyl-6-hydroxyphenol methylaseUniRule annotation (EC:2.1.1.222UniRule annotation)
3-demethylubiquinone 3-O-methyltransferaseUniRule annotation (EC:2.1.1.64UniRule annotation)
Gene namesi
Name:ubiGUniRule annotation
Ordered Locus Names:VV1_3040
OrganismiVibrio vulnificus (strain CMCP6)
Taxonomic identifieri216895 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 235235Ubiquinone biosynthesis O-methyltransferasePRO_0000193407Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi216895.VV1_3040.

Structurei

3D structure databases

ProteinModelPortaliQ8D8E0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily. UbiG/COQ3 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RFD. Bacteria.
COG2227. LUCA.
HOGENOMiHOG000278065.
KOiK00568.
OMAiHDWEKFV.
OrthoDBiPOG091H064Z.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00472. UbiG. 1 hit.
InterProiIPR029063. SAM-dependent_MTases.
IPR010233. UbiG_MeTrfase.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR01983. UbiG. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8D8E0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKTQNVDPN EIKKFEDMAS RWWDLEGEFK PLHQINPLRL DYVLSKADGL
60 70 80 90 100
FGKKVLDVGC GGGILAESMA KEGAVVTGLD MGKEPLEVAR LHALETGTKL
110 120 130 140 150
TYIQSTIEDH AAENAQMYDV VTCMEMLEHV PDPLSVIRSC AALVKPGGHV
160 170 180 190 200
FFSTLNRNIK SYLFAIVGAE KLLKIVPEGT HDHDKFIRPS ELIKMIDQTD
210 220 230
LCEQGITGLH YNPLSDTYKL GRNVDVNYIV HTQKF
Length:235
Mass (Da):26,244
Last modified:March 1, 2003 - v1
Checksum:iA89B7E1F8613F2B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016795 Genomic DNA. Translation: AAO11364.1.
RefSeqiWP_011080845.1. NC_004459.3.

Genome annotation databases

EnsemblBacteriaiAAO11364; AAO11364; VV1_3040.
GeneIDi2624050.
KEGGivvu:VV1_3040.
PATRICi20163053. VBIVibVul94426_3001.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016795 Genomic DNA. Translation: AAO11364.1.
RefSeqiWP_011080845.1. NC_004459.3.

3D structure databases

ProteinModelPortaliQ8D8E0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi216895.VV1_3040.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO11364; AAO11364; VV1_3040.
GeneIDi2624050.
KEGGivvu:VV1_3040.
PATRICi20163053. VBIVibVul94426_3001.

Phylogenomic databases

eggNOGiENOG4107RFD. Bacteria.
COG2227. LUCA.
HOGENOMiHOG000278065.
KOiK00568.
OMAiHDWEKFV.
OrthoDBiPOG091H064Z.

Enzyme and pathway databases

UniPathwayiUPA00232.
BioCyciVVUL216895:GIYM-2745-MONOMER.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00472. UbiG. 1 hit.
InterProiIPR029063. SAM-dependent_MTases.
IPR010233. UbiG_MeTrfase.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR01983. UbiG. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUBIG_VIBVU
AccessioniPrimary (citable) accession number: Q8D8E0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.