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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Vibrio vulnificus (strain CMCP6)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciVVUL216895:G1GJ4-3423-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:VV2_0186
OrganismiVibrio vulnificus (strain CMCP6)
Taxonomic identifieri216895 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001669461 – 954Glycine dehydrogenase (decarboxylating)Add BLAST954

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei704N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiQ8D7G7

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ8D7G7
SMRiQ8D7G7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CBI Bacteria
COG0403 LUCA
COG1003 LUCA
HOGENOMiHOG000239369
KOiK00281
OMAiIRVQVII
OrthoDBiPOG091H03O6

Family and domain databases

CDDicd00613 GDC-P, 2 hits
Gene3Di3.40.640.10, 2 hits
3.90.1150.10, 1 hit
HAMAPiMF_00711 GcvP, 1 hit
InterProiView protein in InterPro
IPR003437 GcvP
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11773 PTHR11773, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 2 hits
SUPFAMiSSF53383 SSF53383, 3 hits
TIGRFAMsiTIGR00461 gcvP, 1 hit

Sequencei

Sequence statusi: Complete.

Q8D7G7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTELLQSLNT QHEFVGRHNG PNHADQQKML STINAESLDA LIAQTVPAQI
60 70 80 90 100
RLEKPMQLAE AQSEADMLAS IKKFADLNQV KRTFIGQGYY NTFTPNVILR
110 120 130 140 150
NVLENPGWYT AYTPYQPEIS QGRLESLLNY QQMVMDLTGM DIANASLLDE
160 170 180 190 200
ATAAAEAMTL CQRAGKSKSK VFFVADDVHP QTIEVIKTRA KYFGFDVVIG
210 220 230 240 250
NVDSLPQTEA FGALLQYPST TGEVRDLTDV ITQAQANKTL VSVATDLLAS
260 270 280 290 300
ALVKPAGEMG ADVVIGSAQR FGVPMGYGGP HAAFMATREQ HKRTMPGRVI
310 320 330 340 350
GVSIDAKGNQ ALRMAMQTRE QHIRREKATS NICTAQALLA NMASFFAVYH
360 370 380 390 400
GEVGIRTIAR RTHHMTAILA AGLTKSGYEL AHNAFFDTIT INTGDNTQAL
410 420 430 440 450
YAKAQAADIN LRLLDGQIGI SFDETTTVAD IDALFAIFDV KESVNALSTD
460 470 480 490 500
IAGNEFAAIP EACRRTSRFL THPVFNTHHS ETQMMRYLKQ LENKDFSLTH
510 520 530 540 550
GMIPLGSCTM KLNAAAEMIP VTWPEFGALH PFAPIEQAAG YTALAEDLKA
560 570 580 590 600
KLCEITGYDA FSLQPNSGAS GEYAGLIAIQ RYHESRGEGH RNVCLIPSSA
610 620 630 640 650
HGTNPATAAM VSMKVVVVKC DENGNIDLVD LAAKIEKHQE NLSSIMITYP
660 670 680 690 700
STHGVYEEQV KEVCEMVHAA GGQVYLDGAN MNAQVGLTSP GFIGSDVSHL
710 720 730 740 750
NLHKTFCIPH GGGGPGMGPI GVKSHLAPFL PGHIENGVEG KEFAVSAADL
760 770 780 790 800
GSASILPISW AYIAMMGADG LTEATKVAIL NANYVMERLR PHYPVLYRGT
810 820 830 840 850
NGRVAHECII DIRPLKEETG ISEEDIAKRL MDYGFHAPTM SFPVAGTLMV
860 870 880 890 900
EPTESEDLEE LDRFCDAMIA IREEMTKVKN GEWPLENNPL VNAPHTQVDL
910 920 930 940 950
MEEQWDRPYP REIACFPSAA TKRSKYWPTV NRVDNVYGDR NLVCSCPGIE

NYEE
Length:954
Mass (Da):104,224
Last modified:March 1, 2003 - v1
Checksum:i29142058BA029E04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016796 Genomic DNA Translation: AAO07159.1
RefSeqiWP_011081166.1, NC_004460.2

Genome annotation databases

EnsemblBacteriaiAAO07159; AAO07159; VV2_0186
KEGGivvu:VV2_0186

Similar proteinsi

Entry informationi

Entry nameiGCSP_VIBVU
AccessioniPrimary (citable) accession number: Q8D7G7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

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