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Q8D7G7 (GCSP_VIBVU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:VV2_0186
OrganismVibrio vulnificus (strain CMCP6) [Complete proteome] [HAMAP]
Taxonomic identifier216895 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length954 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 954954Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_0000166946

Amino acid modifications

Modified residue7041N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8D7G7 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 29142058BA029E04

FASTA954104,224
        10         20         30         40         50         60 
MTELLQSLNT QHEFVGRHNG PNHADQQKML STINAESLDA LIAQTVPAQI RLEKPMQLAE 

        70         80         90        100        110        120 
AQSEADMLAS IKKFADLNQV KRTFIGQGYY NTFTPNVILR NVLENPGWYT AYTPYQPEIS 

       130        140        150        160        170        180 
QGRLESLLNY QQMVMDLTGM DIANASLLDE ATAAAEAMTL CQRAGKSKSK VFFVADDVHP 

       190        200        210        220        230        240 
QTIEVIKTRA KYFGFDVVIG NVDSLPQTEA FGALLQYPST TGEVRDLTDV ITQAQANKTL 

       250        260        270        280        290        300 
VSVATDLLAS ALVKPAGEMG ADVVIGSAQR FGVPMGYGGP HAAFMATREQ HKRTMPGRVI 

       310        320        330        340        350        360 
GVSIDAKGNQ ALRMAMQTRE QHIRREKATS NICTAQALLA NMASFFAVYH GEVGIRTIAR 

       370        380        390        400        410        420 
RTHHMTAILA AGLTKSGYEL AHNAFFDTIT INTGDNTQAL YAKAQAADIN LRLLDGQIGI 

       430        440        450        460        470        480 
SFDETTTVAD IDALFAIFDV KESVNALSTD IAGNEFAAIP EACRRTSRFL THPVFNTHHS 

       490        500        510        520        530        540 
ETQMMRYLKQ LENKDFSLTH GMIPLGSCTM KLNAAAEMIP VTWPEFGALH PFAPIEQAAG 

       550        560        570        580        590        600 
YTALAEDLKA KLCEITGYDA FSLQPNSGAS GEYAGLIAIQ RYHESRGEGH RNVCLIPSSA 

       610        620        630        640        650        660 
HGTNPATAAM VSMKVVVVKC DENGNIDLVD LAAKIEKHQE NLSSIMITYP STHGVYEEQV 

       670        680        690        700        710        720 
KEVCEMVHAA GGQVYLDGAN MNAQVGLTSP GFIGSDVSHL NLHKTFCIPH GGGGPGMGPI 

       730        740        750        760        770        780 
GVKSHLAPFL PGHIENGVEG KEFAVSAADL GSASILPISW AYIAMMGADG LTEATKVAIL 

       790        800        810        820        830        840 
NANYVMERLR PHYPVLYRGT NGRVAHECII DIRPLKEETG ISEEDIAKRL MDYGFHAPTM 

       850        860        870        880        890        900 
SFPVAGTLMV EPTESEDLEE LDRFCDAMIA IREEMTKVKN GEWPLENNPL VNAPHTQVDL 

       910        920        930        940        950 
MEEQWDRPYP REIACFPSAA TKRSKYWPTV NRVDNVYGDR NLVCSCPGIE NYEE 

« Hide

References

[1]"Complete genome sequence of Vibrio vulnificus CMCP6."
Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E.
Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CMCP6.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016796 Genomic DNA. Translation: AAO07159.1.
RefSeqNP_762169.1. NC_004460.2.

3D structure databases

ProteinModelPortalQ8D7G7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING216895.VV2_0186.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO07159; AAO07159; VV2_0186.
GeneID1180210.
KEGGvvu:VV2_0186.
PATRIC20163775. VBIVibVul94426_3350.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAHTQVDLM.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Enzyme and pathway databases

BioCycVVUL216895:GIYM-3069-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_VIBVU
AccessionPrimary (citable) accession number: Q8D7G7
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: March 1, 2003
Last modified: February 19, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families