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Q8D7G7

- GCSP_VIBVU

UniProt

Q8D7G7 - GCSP_VIBVU

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Vibrio vulnificus (strain CMCP6)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciVVUL216895:GIYM-3069-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:VV2_0186
    OrganismiVibrio vulnificus (strain CMCP6)
    Taxonomic identifieri216895 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000002275: Chromosome 2

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 954954Glycine dehydrogenase (decarboxylating)PRO_0000166946Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei704 – 7041N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi216895.VV2_0186.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8D7G7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiIRVQVII.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8D7G7-1 [UniParc]FASTAAdd to Basket

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    MTELLQSLNT QHEFVGRHNG PNHADQQKML STINAESLDA LIAQTVPAQI    50
    RLEKPMQLAE AQSEADMLAS IKKFADLNQV KRTFIGQGYY NTFTPNVILR 100
    NVLENPGWYT AYTPYQPEIS QGRLESLLNY QQMVMDLTGM DIANASLLDE 150
    ATAAAEAMTL CQRAGKSKSK VFFVADDVHP QTIEVIKTRA KYFGFDVVIG 200
    NVDSLPQTEA FGALLQYPST TGEVRDLTDV ITQAQANKTL VSVATDLLAS 250
    ALVKPAGEMG ADVVIGSAQR FGVPMGYGGP HAAFMATREQ HKRTMPGRVI 300
    GVSIDAKGNQ ALRMAMQTRE QHIRREKATS NICTAQALLA NMASFFAVYH 350
    GEVGIRTIAR RTHHMTAILA AGLTKSGYEL AHNAFFDTIT INTGDNTQAL 400
    YAKAQAADIN LRLLDGQIGI SFDETTTVAD IDALFAIFDV KESVNALSTD 450
    IAGNEFAAIP EACRRTSRFL THPVFNTHHS ETQMMRYLKQ LENKDFSLTH 500
    GMIPLGSCTM KLNAAAEMIP VTWPEFGALH PFAPIEQAAG YTALAEDLKA 550
    KLCEITGYDA FSLQPNSGAS GEYAGLIAIQ RYHESRGEGH RNVCLIPSSA 600
    HGTNPATAAM VSMKVVVVKC DENGNIDLVD LAAKIEKHQE NLSSIMITYP 650
    STHGVYEEQV KEVCEMVHAA GGQVYLDGAN MNAQVGLTSP GFIGSDVSHL 700
    NLHKTFCIPH GGGGPGMGPI GVKSHLAPFL PGHIENGVEG KEFAVSAADL 750
    GSASILPISW AYIAMMGADG LTEATKVAIL NANYVMERLR PHYPVLYRGT 800
    NGRVAHECII DIRPLKEETG ISEEDIAKRL MDYGFHAPTM SFPVAGTLMV 850
    EPTESEDLEE LDRFCDAMIA IREEMTKVKN GEWPLENNPL VNAPHTQVDL 900
    MEEQWDRPYP REIACFPSAA TKRSKYWPTV NRVDNVYGDR NLVCSCPGIE 950
    NYEE 954
    Length:954
    Mass (Da):104,224
    Last modified:March 1, 2003 - v1
    Checksum:i29142058BA029E04
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016796 Genomic DNA. Translation: AAO07159.1.
    RefSeqiNP_762169.1. NC_004460.2.

    Genome annotation databases

    EnsemblBacteriaiAAO07159; AAO07159; VV2_0186.
    GeneIDi1180210.
    KEGGivvu:VV2_0186.
    PATRICi20163775. VBIVibVul94426_3350.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016796 Genomic DNA. Translation: AAO07159.1 .
    RefSeqi NP_762169.1. NC_004460.2.

    3D structure databases

    ProteinModelPortali Q8D7G7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 216895.VV2_0186.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO07159 ; AAO07159 ; VV2_0186 .
    GeneIDi 1180210.
    KEGGi vvu:VV2_0186.
    PATRICi 20163775. VBIVibVul94426_3350.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi IRVQVII.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci VVUL216895:GIYM-3069-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Vibrio vulnificus CMCP6."
      Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E.
      Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CMCP6.

    Entry informationi

    Entry nameiGCSP_VIBVU
    AccessioniPrimary (citable) accession number: Q8D7G7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3