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Q8D7D8

- FTHS_VIBVU

UniProt

Q8D7D8 - FTHS_VIBVU

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Protein

Formate--tetrahydrofolate ligase

Gene
fhs, VV2_0216, VV2_0217
Organism
Vibrio vulnificus (strain CMCP6)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciVVUL216895:GIYM-3097-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:VV2_0216
ORF Names:VV2_0217
OrganismiVibrio vulnificus (strain CMCP6)
Taxonomic identifieri216895 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000002275: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 582582Formate--tetrahydrofolate ligaseUniRule annotationPRO_0000199410Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi216895.VV2_0216.

Structurei

3D structure databases

ProteinModelPortaliQ8D7D8.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8D7D8-1 [UniParc]FASTAAdd to Basket

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MLSDIDICRT TPLKPIEQIA AKAGLLADEF ETHGLYKAKV SARCVKRLAE    50
QQDGKLVLVT AITPTPLGEG KTVTTIGLAQ GLQSLNQSVM ACIRQPSMGP 100
VFGVKGGAAG GGYSQVAPMD ELNLHLTGDI HAVTAAHNLA AAAIDARIYH 150
EQRAGYQAFE ARTGLPALRI DPDRVVWKRV MDHNDRALRK VRVGINDEGK 200
TINGFEREEG FDISAASELM AILALSKNLQ DMRERIGKVV LAYNLDSEPV 250
SAEQLQVAGA MTVTLKEAIK PTLMQTLEGV PTLIHAGPFA NIAHGNSSII 300
ADEIALKLSS YVVTEAGFGS DMGLEKACNI KSSTSHKAPD CVVIVATLRG 350
LKANSGLYDL KPGMPLPDAL FQPDRAALES GFSNLKWHID NAQKYGLPVV 400
VAINQFPQDS AEELGQLKLW IQQLPLNVRV AISEGFAKGG KGMEAVAREV 450
IEACDAPANF RPLYRAEQTL EEKIITVCTK GYGCGEVQFS DTAKQQLALY 500
QTLGFGELAV CMAKTPLSIS SDSSLKGAPS GFTIMVREVR LCAGAGFVYA 550
LTGNVMTMPG LPDIPAFMAL DIDENGDIVG LS 582
Length:582
Mass (Da):62,201
Last modified:December 6, 2005 - v2
Checksum:i25EDDDE568C8D299
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016796 Genomic DNA. Translation: AAO07187.2.
RefSeqiNP_762197.2. NC_004460.2.
WP_011081194.1. NC_004460.2.

Genome annotation databases

EnsemblBacteriaiAAO07187; AAO07187; VV2_0216.
GeneIDi1180238.
KEGGivvu:VV2_0216.
PATRICi20163835. VBIVibVul94426_3380.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016796 Genomic DNA. Translation: AAO07187.2 .
RefSeqi NP_762197.2. NC_004460.2.
WP_011081194.1. NC_004460.2.

3D structure databases

ProteinModelPortali Q8D7D8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 216895.VV2_0216.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO07187 ; AAO07187 ; VV2_0216 .
GeneIDi 1180238.
KEGGi vvu:VV2_0216.
PATRICi 20163835. VBIVibVul94426_3380.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci VVUL216895:GIYM-3097-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete genome sequence of Vibrio vulnificus CMCP6."
    Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E.
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CMCP6.
  2. "Integrative genome-scale metabolic analysis of Vibrio vulnificus for drug targeting and discovery."
    Kim H.U., Kim S.Y., Jeong H., Kim T.Y., Kim J.J., Choy H.E., Yi K.Y., Rhee J.H., Lee S.Y.
    Mol. Syst. Biol. 7:460-460(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.

Entry informationi

Entry nameiFTHS_VIBVU
AccessioniPrimary (citable) accession number: Q8D7D8
Secondary accession number(s): Q8D7D9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: September 3, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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