Q8D7D8 (FTHS_VIBVU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Formate--tetrahydrofolate ligase
EC=6.3.4.3

Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS

Gene names

Name:	fhs
Ordered Locus Names:	VV2_0216
ORF Names:	VV2_0217

Organism

Vibrio vulnificus (strain CMCP6) [Complete proteome] [HAMAP]

Taxonomic identifier

216895 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio › Vibrio vulnificus

Protein attributes

Sequence length	582 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543
Sequence similarities	Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	folic acid-containing compound biosynthetic process Inferred from electronic annotation. Source: InterPro tetrahydrofolate interconversion Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP formate-tetrahydrofolate ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 582	582	Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543		PRO_0000199410
Regions
	Nucleotide binding	65 – 72	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8D7D8 [UniParc]. Last modified December 6, 2005. Version 2. Checksum: 25EDDDE568C8D299	FASTA	582	62,201
	10 20 30 40 50 60 MLSDIDICRT TPLKPIEQIA AKAGLLADEF ETHGLYKAKV SARCVKRLAE QQDGKLVLVT 70 80 90 100 110 120 AITPTPLGEG KTVTTIGLAQ GLQSLNQSVM ACIRQPSMGP VFGVKGGAAG GGYSQVAPMD 130 140 150 160 170 180 ELNLHLTGDI HAVTAAHNLA AAAIDARIYH EQRAGYQAFE ARTGLPALRI DPDRVVWKRV 190 200 210 220 230 240 MDHNDRALRK VRVGINDEGK TINGFEREEG FDISAASELM AILALSKNLQ DMRERIGKVV 250 260 270 280 290 300 LAYNLDSEPV SAEQLQVAGA MTVTLKEAIK PTLMQTLEGV PTLIHAGPFA NIAHGNSSII 310 320 330 340 350 360 ADEIALKLSS YVVTEAGFGS DMGLEKACNI KSSTSHKAPD CVVIVATLRG LKANSGLYDL 370 380 390 400 410 420 KPGMPLPDAL FQPDRAALES GFSNLKWHID NAQKYGLPVV VAINQFPQDS AEELGQLKLW 430 440 450 460 470 480 IQQLPLNVRV AISEGFAKGG KGMEAVAREV IEACDAPANF RPLYRAEQTL EEKIITVCTK 490 500 510 520 530 540 GYGCGEVQFS DTAKQQLALY QTLGFGELAV CMAKTPLSIS SDSSLKGAPS GFTIMVREVR 550 560 570 580 LCAGAGFVYA LTGNVMTMPG LPDIPAFMAL DIDENGDIVG LS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of Vibrio vulnificus CMCP6." Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E. Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CMCP6.
[2]	"Integrative genome-scale metabolic analysis of Vibrio vulnificus for drug targeting and discovery." Kim H.U., Kim S.Y., Jeong H., Kim T.Y., Kim J.J., Choy H.E., Yi K.Y., Rhee J.H., Lee S.Y. Mol. Syst. Biol. 7:460-460(2011) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016796 Genomic DNA. Translation: AAO07187.2.
RefSeq	NP_762197.2. NC_004460.2.
3D structure databases
ProteinModelPortal	Q8D7D8.
ModBase	Search...
Protein-protein interaction databases
STRING	216895.VV2_0216.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAO07187; AAO07187; VV2_0216.
GeneID	1180238.
KEGG	vvu:VV2_0216.
PATRIC	20163835. VBIVibVul94426_3380.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2759.
HOGENOM	HOG000040280.
KO	K01938.
Enzyme and pathway databases
UniPathway	UPA00193.
Family and domain databases
HAMAP	MF_01543. FTHFS.
InterPro	IPR000559. Formate_THF_ligase. IPR020628. Formate_THF_ligase_CS. [Graphical view]
Pfam	PF01268. FTHFS. 1 hit. [Graphical view]
PROSITE	PS00721. FTHFS_1. 1 hit. PS00722. FTHFS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FTHS_VIBVU

Accession

Primary (citable) accession number: Q8D7D8
Secondary accession number(s): Q8D7D9

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	December 6, 2005
Last modified:	May 1, 2013
This is version 61 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program