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Q8D7D8

- FTHS_VIBVU

UniProt

Q8D7D8 - FTHS_VIBVU

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Vibrio vulnificus (strain CMCP6)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 2 (06 Dec 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciVVUL216895:GIYM-3097-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:VV2_0216
    ORF Names:VV2_0217
    OrganismiVibrio vulnificus (strain CMCP6)
    Taxonomic identifieri216895 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000002275: Chromosome 2

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 582582Formate--tetrahydrofolate ligasePRO_0000199410Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi216895.VV2_0216.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8D7D8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8D7D8-1 [UniParc]FASTAAdd to Basket

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    MLSDIDICRT TPLKPIEQIA AKAGLLADEF ETHGLYKAKV SARCVKRLAE    50
    QQDGKLVLVT AITPTPLGEG KTVTTIGLAQ GLQSLNQSVM ACIRQPSMGP 100
    VFGVKGGAAG GGYSQVAPMD ELNLHLTGDI HAVTAAHNLA AAAIDARIYH 150
    EQRAGYQAFE ARTGLPALRI DPDRVVWKRV MDHNDRALRK VRVGINDEGK 200
    TINGFEREEG FDISAASELM AILALSKNLQ DMRERIGKVV LAYNLDSEPV 250
    SAEQLQVAGA MTVTLKEAIK PTLMQTLEGV PTLIHAGPFA NIAHGNSSII 300
    ADEIALKLSS YVVTEAGFGS DMGLEKACNI KSSTSHKAPD CVVIVATLRG 350
    LKANSGLYDL KPGMPLPDAL FQPDRAALES GFSNLKWHID NAQKYGLPVV 400
    VAINQFPQDS AEELGQLKLW IQQLPLNVRV AISEGFAKGG KGMEAVAREV 450
    IEACDAPANF RPLYRAEQTL EEKIITVCTK GYGCGEVQFS DTAKQQLALY 500
    QTLGFGELAV CMAKTPLSIS SDSSLKGAPS GFTIMVREVR LCAGAGFVYA 550
    LTGNVMTMPG LPDIPAFMAL DIDENGDIVG LS 582
    Length:582
    Mass (Da):62,201
    Last modified:December 6, 2005 - v2
    Checksum:i25EDDDE568C8D299
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016796 Genomic DNA. Translation: AAO07187.2.
    RefSeqiNP_762197.2. NC_004460.2.
    WP_011081194.1. NC_004460.2.

    Genome annotation databases

    EnsemblBacteriaiAAO07187; AAO07187; VV2_0216.
    GeneIDi1180238.
    KEGGivvu:VV2_0216.
    PATRICi20163835. VBIVibVul94426_3380.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016796 Genomic DNA. Translation: AAO07187.2 .
    RefSeqi NP_762197.2. NC_004460.2.
    WP_011081194.1. NC_004460.2.

    3D structure databases

    ProteinModelPortali Q8D7D8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 216895.VV2_0216.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO07187 ; AAO07187 ; VV2_0216 .
    GeneIDi 1180238.
    KEGGi vvu:VV2_0216.
    PATRICi 20163835. VBIVibVul94426_3380.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci VVUL216895:GIYM-3097-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Vibrio vulnificus CMCP6."
      Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E.
      Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CMCP6.
    2. "Integrative genome-scale metabolic analysis of Vibrio vulnificus for drug targeting and discovery."
      Kim H.U., Kim S.Y., Jeong H., Kim T.Y., Kim J.J., Choy H.E., Yi K.Y., Rhee J.H., Lee S.Y.
      Mol. Syst. Biol. 7:460-460(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.

    Entry informationi

    Entry nameiFTHS_VIBVU
    AccessioniPrimary (citable) accession number: Q8D7D8
    Secondary accession number(s): Q8D7D9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 67 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3