Q8D740 (MODC_VIBVU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Molybdenum import ATP-binding protein ModC
EC=3.6.3.29

Gene names

Name:	modC
Ordered Locus Names:	VV2_0327

Organism

Vibrio vulnificus (strain CMCP6) [Complete proteome] [HAMAP]

Taxonomic identifier

216895 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio › Vibrio vulnificus

Protein attributes

Sequence length	368 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system By similarity.
Catalytic activity	ATP + H2O + molybdate(Out) = ADP + phosphate + molybdate(In).
Subunit structure	The complex is composed of two ATP-binding proteins (ModC), two transmembrane proteins (ModB) and a solute-binding protein (ModA) Potential.
Subcellular location	Cell inner membrane; Peripheral membrane protein By similarity.
Sequence similarities	Belongs to the ABC transporter superfamily. Molybdate importer (TC 3.A.1.8) family. [View classification] Contains 1 ABC transporter domain.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Ligand	ATP-binding Molybdenum Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	ATP catabolic process Inferred from electronic annotation. Source: GOC
Cellular_component	ATP-binding cassette (ABC) transporter complex Inferred from electronic annotation. Source: InterPro plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW molybdate transmembrane-transporting ATPase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 368	368	Molybdenum import ATP-binding protein ModC		PRO_0000092561
Regions
	Domain	1 – 231	231	ABC transporter
	Nucleotide binding	33 – 40	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8D740 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 34630224037E0AE8	FASTA	368	40,963
	10 20 30 40 50 60 MKGLQVAFKQ TLGHVVFDIE LQLPSKGVSA IFGRSGAGKT SIINVISGLT QPEQGRIALN 70 80 90 100 110 120 SDVLFDSVLG INVPVHQRNI GYVFQDSRLF PHYHVEGNLK YGVKQYDAEM FDKVVTLLAL 130 140 150 160 170 180 QPLLKRYPAS LSGGEKQRVA IGRALLSSPK ILLMDEPLAS LDMPRKKEVL PFLEKLSESF 190 200 210 220 230 240 EIPIVYVTHS LQEILRLADH LTVLDRGQIV ASGLLSEVWS SQAMRPWQSF SEQSTLFNAN 250 260 270 280 290 300 IAEQHPQYAL TRVMLSSTAS LWVQKIDAPL GSDIRLQVRA NDVSITLVQP QKTSIRNIIE 310 320 330 340 350 360 AKVERVEKRH PAEDKESIAV KLALTQDCFL WATITPWALA DLNLKQGDRV FAQIKGVSVT QRDIALTH

References

[1]	"Complete genome sequence of Vibrio vulnificus CMCP6." Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E. Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CMCP6.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016796 Genomic DNA. Translation: AAO07287.1.
RefSeq	NP_762297.1. NC_004460.2.
3D structure databases
ProteinModelPortal	Q8D740.
ModBase	Search...
Protein-protein interaction databases
STRING	216895.VV2_0327.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAO07287; AAO07287; VV2_0327.
GeneID	1180338.
KEGG	vvu:VV2_0327.
PATRIC	20164054. VBIVibVul94426_3489.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG4148.
KO	K02017.
OMA	TTCLRCI.
ProtClustDB	PRK11144.
Enzyme and pathway databases
BioCyc	VVUL216895:GIYM-3191-MONOMER.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR008995. Mo/tungstate-bd_C_term_dom. IPR011868. ModC_ABC_ATP-bd. IPR027417. P-loop_NTPase. IPR005116. Transp-assoc_OB_typ1. [Graphical view]
Pfam	PF00005. ABC_tran. 1 hit. PF03459. TOBE. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
SUPFAM	SSF50331. MOP_like. 1 hit. SSF52540. SSF52540. 1 hit.
TIGRFAMs	TIGR02142. modC_ABC. 1 hit.
PROSITE	PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. PS51241. MODC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MODC_VIBVU

Accession

Primary (citable) accession number: Q8D740

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	March 1, 2003
Last modified:	May 29, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program