Q8D6Q0 (ALR2_VIBVU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alanine racemase 2
EC=5.1.1.1

Gene names

Name:	alr2
Ordered Locus Names:	VV2_0478

Organism

Vibrio vulnificus [Complete proteome] [HAMAP]

Taxonomic identifier

672 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length	408 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Provides the D-alanine required for cell wall biosynthesis By similarity. HAMAP MF_01201
Catalytic activity	L-alanine = D-alanine. HAMAP MF_01201
Cofactor	Pyridoxal phosphate By similarity. HAMAP MF_01201
Pathway	Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP MF_01201 Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_01201
Sequence similarities	Belongs to the alanine racemase family.

Ontologies

Keywords
Biological process	Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Ligand	Pyridoxal phosphate
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	alanine metabolic process Inferred from electronic annotation. Source: InterPro cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alanine racemase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 408	408	Alanine racemase 2 HAMAP MF_01201		PRO_0000114596
Sites
	Active site	75	1	Proton acceptor; specific for D-alanine By similarity
	Active site	300	1	Proton acceptor; specific for L-alanine By similarity
Amino acid modifications
	Modified residue	75	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8D6Q0 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 3D8A964B40B670F4	FASTA	408	44,106
	10 20 30 40 50 60 MNFKKTLLSI AIASASLTPA FSYSAPLLLD NTVHQTSQIA GANAWLEISL GQFKSNIEQF 70 80 90 100 110 120 KSHIAPQTKI CAVMKADAYG NGIRGLMPTI LEQQIPCVAI ASNAEAKLVR ESGFEGELIR 130 140 150 160 170 180 VRSASTSEIE QALSLDIEEL IGSEQQAREL ASLAEKYSKT IKVHLALNDG GMGRNGIDMS 190 200 210 220 230 240 TERGPKEAVA IATHPSVAVV GIMTHFPNYN AEDVRTKLKS FNQHAQWLME SAGLKREEIT 250 260 270 280 290 300 LHVANSYTAL NVPEAQLDMV RPGGVLYGDL PTNPEYPSIV AFKTRVASLH SLPAGSTVGY 310 320 330 340 350 360 DSTFTTANDA VMANLTVGYS DGYPRKMGNK AQVLINGQRA NVVGVASMNT TMVDVSNIKG 370 380 390 400 VLPGDEVTLF GAQKNQHISV GEMEENAEVI FPELYTIWGT SNPRFYVK

References

[1]	"Complete genome sequence of Vibrio vulnificus CMCP6." Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E. Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CMCP6.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016796 Genomic DNA. Translation: AAO07429.1.
RefSeq	NP_762439.1. NC_004460.2.
3D structure databases
ProteinModelPortal	Q8D6Q0.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1180481.
GenomeReviews	Gene locus VV2_0478 in contig AE016796_GR.
KEGG	vvu:VV2_0478.
PATRIC	20164344. VBIVibVul94426_3633.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG291652.
OMA	NTVGYDR.
ProtClustDB	PRK13340.
Enzyme and pathway databases
BioCyc	VVUL216895:VV2_0478-MONOMER.
Family and domain databases
HAMAP	MF_01201. Ala_racemase. [Tree]
InterPro	IPR000821. Ala_racemase. IPR009006. Ala_racemase/Decarboxylase_C. IPR011079. Ala_racemase_C. IPR001608. Ala_racemase_N. IPR020622. Ala_racemase_pyridoxalP-BS. [Graphical view]
Gene3D	G3DSA:2.40.37.10. Ala_racemase/Decarboxylase_C. 1 hit.
KO	K01775.
Pfam	PF00842. Ala_racemase_C. 1 hit. PF01168. Ala_racemase_N. 1 hit. [Graphical view]
PRINTS	PR00992. ALARACEMASE.
SMART	SM01005. Ala_racemase_C. 1 hit. [Graphical view]
SUPFAM	SSF50621. Racem_decarbox_C. 1 hit.
TIGRFAMs	TIGR00492. Alr. 1 hit.
PROSITE	PS00395. ALANINE_RACEMASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALR2_VIBVU

Accession

Primary (citable) accession number: Q8D6Q0

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 15, 2003
Last sequence update:	March 1, 2003
Last modified:	January 25, 2012
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program