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Protein

Chemotaxis response regulator protein-glutamate methylesterase of group 2 operon

Gene

cheB2

Organism
Vibrio vulnificus (strain CMCP6)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in the modulation of the chemotaxis system; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR.By similarity

Catalytic activityi

Protein L-glutamate O5-methyl ester + H2O = protein L-glutamate + methanol.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei165By similarity1
Active sitei191By similarity1
Active sitei288By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processChemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis response regulator protein-glutamate methylesterase of group 2 operon (EC:3.1.1.61)
Gene namesi
Name:cheB2
Ordered Locus Names:VV2_1161
OrganismiVibrio vulnificus (strain CMCP6)
Taxonomic identifieri216895 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001580401 – 344Chemotaxis response regulator protein-glutamate methylesterase of group 2 operonAdd BLAST344

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei574-aspartylphosphateBy similarity1

Post-translational modificationi

Phosphorylated by CheA. Phosphorylation suppresses the inhibitory activity of the N-terminal domain (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliQ8D4X6.
SMRiQ8D4X6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 123Response regulatoryPROSITE-ProRule annotationAdd BLAST118
Domaini153 – 344CheB-type methylesteraseAdd BLAST192

Domaini

The N-terminal regulatory domain inhibits the activity of the C-terminal effector domain.By similarity

Phylogenomic databases

eggNOGiENOG4105CMP. Bacteria.
COG2201. LUCA.
HOGENOMiHOG000151423.
KOiK03412.
OMAiAMVKIRQ.
OrthoDBiPOG091H045J.

Family and domain databases

CDDicd16432. CheB_Rec. 1 hit.
cd00156. REC. 1 hit.
Gene3Di3.40.50.180. 1 hit.
HAMAPiMF_00099. CheB_methylest. 1 hit.
InterProiView protein in InterPro
IPR035909. CheB_C.
IPR011006. CheY-like_superfamily.
IPR008248. Sig_transdc_resp-reg_CheB.
IPR000673. Sig_transdc_resp-reg_Me-estase.
IPR001789. Sig_transdc_resp-reg_receiver.
PfamiView protein in Pfam
PF01339. CheB_methylest. 1 hit.
PF00072. Response_reg. 1 hit.
PIRSFiPIRSF000876. RR_chemtxs_CheB. 1 hit.
SMARTiView protein in SMART
SM00448. REC. 1 hit.
SUPFAMiSSF52172. SSF52172. 1 hit.
SSF52738. SSF52738. 1 hit.
PROSITEiView protein in PROSITE
PS50122. CHEB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8D4X6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKKIKVLVV DDSPVFRALL SEIINSDPQL EVIGAAEDPY QAREMIKALK
60 70 80 90 100
PDVLTLDIEM PKMNGVQFLK NLMRLHPLPV VMISTLTQHG ADATLMALEL
110 120 130 140 150
GAVDYFPKPS VANTADMLGY RSLVNEKIRM AAQAQVGANQ SMSPAVASSS
160 170 180 190 200
AVSTSQYQLI AIGASTGGTE AVKHLLSALP ASMPPIVITQ HISAMFSGPF
210 220 230 240 250
ASRLDASCAL SVSELTQGEV ALKTNHAYVA PGDKHLMVFR RGGQLYAHLD
260 270 280 290 300
DSPAVNRHKP SVDVMFGSVA ESLKGKAIGV ILTGMGKDGA QGMLQMKQQG
310 320 330 340
AITVAQDEQS CVVYGMPRAA VECGAAMHIK PLNKLPQFLC DLLS
Length:344
Mass (Da):36,608
Last modified:March 1, 2003 - v1
Checksum:i404300A9AC50AB8F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016796 Genomic DNA. Translation: AAO08060.1.

Genome annotation databases

EnsemblBacteriaiAAO08060; AAO08060; VV2_1161.
KEGGivvu:VV2_1161.

Similar proteinsi

Entry informationi

Entry nameiCHEB2_VIBVU
AccessioniPrimary (citable) accession number: Q8D4X6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: March 1, 2003
Last modified: November 22, 2017
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program