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Protein

Purine nucleoside phosphorylase DeoD-type 2

Gene

deoD2

Organism
Vibrio vulnificus (strain CMCP6)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.UniRule annotation
Purine deoxynucleoside + phosphate = purine + 2'-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei5Purine nucleoside; shared with dimeric partnerBy similarity1
Binding sitei21Phosphate; via amide nitrogenBy similarity1
Binding sitei25PhosphateBy similarity1
Binding sitei44Phosphate; shared with dimeric partnerBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Purine nucleoside phosphorylase DeoD-type 2UniRule annotation (EC:2.4.2.1UniRule annotation)
Short name:
PNP 2UniRule annotation
Gene namesi
Name:deoD2UniRule annotation
Ordered Locus Names:VV2_1540
OrganismiVibrio vulnificus (strain CMCP6)
Taxonomic identifieri216895 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000631771 – 236Purine nucleoside phosphorylase DeoD-type 2Add BLAST236

Interactioni

Subunit structurei

Homohexamer.UniRule annotation

Protein-protein interaction databases

STRINGi216895.VV2_1540.

Structurei

3D structure databases

ProteinModelPortaliQ8D3Z2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni88 – 91Phosphate bindingBy similarity4
Regioni180 – 182Purine nucleoside bindingBy similarity3
Regioni204 – 205Purine nucleoside bindingBy similarity2

Sequence similaritiesi

Belongs to the PNP/UDP phosphorylase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D3A. Bacteria.
COG0813. LUCA.
HOGENOMiHOG000274896.
KOiK03784.
OMAiQYNSIRN.
OrthoDBiPOG091H02M1.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
HAMAPiMF_01627. Pur_nucleosid_phosp. 1 hit.
InterProiIPR004402. DeoD-type.
IPR018017. Nucleoside_phosphorylase.
IPR000845. Nucleoside_phosphorylase_d.
[Graphical view]
PANTHERiPTHR21234. PTHR21234. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR00107. deoD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8D3Z2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATPHINAQP GDFAETVLMP GDPLRAKYIA ETFLEDVKQV CDVRNMFGFT
60 70 80 90 100
GTYKGKKVSV MGHGMGIPSA CIYVHELIAE YGVKNVIRVG SCGAVRDDVN
110 120 130 140 150
LMDVVIGMGA STDSKVNRIR FNDHDFAALA DYGLLEEAVK QARAQNVPVK
160 170 180 190 200
VGNVFSADLF YTPEADIFEK MEKLGILGVD MEAAGIYGVA ADLKAKALTI
210 220 230
LTVSDHIIRG EKLSSEDRQK SFNDMMKVAL ETAINL
Length:236
Mass (Da):25,668
Last modified:March 1, 2003 - v1
Checksum:i50AA3F3DE816C2E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016796 Genomic DNA. Translation: AAO08404.1.
RefSeqiWP_011082389.1. NC_004460.2.

Genome annotation databases

EnsemblBacteriaiAAO08404; AAO08404; VV2_1540.
GeneIDi2621360.
KEGGivvu:VV2_1540.
PATRICi20166426. VBIVibVul94426_4662.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016796 Genomic DNA. Translation: AAO08404.1.
RefSeqiWP_011082389.1. NC_004460.2.

3D structure databases

ProteinModelPortaliQ8D3Z2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi216895.VV2_1540.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO08404; AAO08404; VV2_1540.
GeneIDi2621360.
KEGGivvu:VV2_1540.
PATRICi20166426. VBIVibVul94426_4662.

Phylogenomic databases

eggNOGiENOG4105D3A. Bacteria.
COG0813. LUCA.
HOGENOMiHOG000274896.
KOiK03784.
OMAiQYNSIRN.
OrthoDBiPOG091H02M1.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
HAMAPiMF_01627. Pur_nucleosid_phosp. 1 hit.
InterProiIPR004402. DeoD-type.
IPR018017. Nucleoside_phosphorylase.
IPR000845. Nucleoside_phosphorylase_d.
[Graphical view]
PANTHERiPTHR21234. PTHR21234. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR00107. deoD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDEOD2_VIBVU
AccessioniPrimary (citable) accession number: Q8D3Z2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.