ID   BETB_VIBVU              Reviewed;         486 AA.
AC   Q8D3K3;
DT   01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   16-JUN-2009, entry version 42.
DE   RecName: Full=Betaine aldehyde dehydrogenase;
DE            Short=BADH;
DE            EC=1.2.1.8;
GN   Name=betB; OrderedLocusNames=VV2_1687;
OS   Vibrio vulnificus.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales;
OC   Vibrionaceae; Vibrio.
OX   NCBI_TaxID=672;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CMCP6;
RA   Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H.,
RA   Choy H.E.;
RT   "Complete genome sequence of Vibrio vulnificus CMCP6.";
RL   Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Betaine aldehyde + NAD(+) + H(2)O = betaine +
CC       NADH.
CC   -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis
CC       via choline pathway; betaine from betaine aldehyde: step 1/1.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AE016796; AAO08543.1; -; Genomic_DNA.
DR   RefSeq; NP_763553.1; -.
DR   HSSP; P56533; 1A4S.
DR   GeneID; 1181605; -.
DR   GenomeReviews; AE016796_GR; VV2_1687.
DR   KEGG; vvu:VV2_1687; -.
DR   HOGENOM; Q8D3K3; -.
DR   OMA; Q8D3K3; APNGYFV.
DR   BioCyc; VVUL216895:VV2_1687-MON; -.
DR   BRENDA; 1.2.1.8; 277169.
DR   GO; GO:0008802; F:betaine-aldehyde dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0019285; P:glycine betaine biosynthetic process from c...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00804; -; 1.
DR   InterPro; IPR016160; Ald_DH_CS.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH.
DR   Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; FALSE_NEG.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Complete proteome; NAD; Oxidoreductase.
FT   CHAIN         1    486       Betaine aldehyde dehydrogenase.
FT                                /FTId=PRO_0000056556.
FT   NP_BIND     225    230       NAD (By similarity).
FT   ACT_SITE    247    247       By similarity.
FT   ACT_SITE    281    281       By similarity.
SQ   SEQUENCE   486 AA;  52281 MW;  26B432CE203BD763 CRC64;
     MEVTAHYIGG KPFVGDTGES FATLNPATGE VLAHIEQADE RVLGHAIESA KLGFSVWSSM
     SAAERSRCLL KAAQLIRDHN DELAELEVRD TGKPIQEASV VDIATGADVI EYFAGLVNGL
     GGEQQSLGSN QFFYTRREPL GICAGIGAWN YPIQIAMWKA APALAAGNAM IFKPSEETPL
     SALKLAELFT QAGVPDGVFN VVQGDYRVGQ MLTAHPEIDK VSFTGESGTG KKVMADSAAT
     LKPVTMELGG KSPLIIFDDA DLDDAVSAAM VANFYTQGEV CTHGTRVYVQ RAMYDAFVEQ
     LKERTEKLIV GDPMNMETQI GSLISKSHLE KVLGAISSAK ESGATLLTGG FQVTERGLEK
     GCFVAPTVFV DCRDEMPHVQ NEIFGPVMSV LVFDDEDEVI ARANNTQYGL AAGVFTQNLS
     KAHRVIHQLQ AGICWINTWG NSPAEMPVGG YKLSGIGREN GQETLLHYTQ TKSVFVELGA
     FDSPYA
//