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Q8D3K3 (BETB_VIBVU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NAD/NADP-dependent betaine aldehyde dehydrogenase

Short name=BADH
EC=1.2.1.8
Gene names
Name:betB
Ordered Locus Names:VV2_1687
OrganismVibrio vulnificus (strain CMCP6) [Complete proteome] [HAMAP]
Taxonomic identifier216895 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length486 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid By similarity. HAMAP-Rule MF_00804

Catalytic activity

Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP-Rule MF_00804

Cofactor

Binds 2 potassium ions per subunit By similarity. HAMAP-Rule MF_00804

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. HAMAP-Rule MF_00804

Subunit structure

Dimer of dimers By similarity. HAMAP-Rule MF_00804

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   LigandMetal-binding
NAD
NADP
Potassium
   Molecular functionOxidoreductase
   PTMOxidation
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycine betaine biosynthetic process from choline

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionbetaine-aldehyde dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 486486NAD/NADP-dependent betaine aldehyde dehydrogenase HAMAP-Rule MF_00804
PRO_0000056556

Regions

Nucleotide binding147 – 1504NAD/NADP By similarity
Nucleotide binding173 – 1764NAD/NADP By similarity
Nucleotide binding225 – 2306NAD/NADP By similarity

Sites

Active site1591Charge relay system By similarity
Active site2471Proton acceptor By similarity
Active site4591Charge relay system By similarity
Metal binding231Potassium 1 By similarity
Metal binding901Potassium 1 By similarity
Metal binding2411Potassium 2; via carbonyl oxygen By similarity
Metal binding4521Potassium 2; via carbonyl oxygen By similarity
Metal binding4551Potassium 2; via carbonyl oxygen By similarity
Binding site2811NAD/NADP By similarity
Binding site3821NAD/NADP By similarity

Amino acid modifications

Modified residue2811Cysteine sulfenic acid (-SOH) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8D3K3 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 26B432CE203BD763

FASTA48652,281
        10         20         30         40         50         60 
MEVTAHYIGG KPFVGDTGES FATLNPATGE VLAHIEQADE RVLGHAIESA KLGFSVWSSM 

        70         80         90        100        110        120 
SAAERSRCLL KAAQLIRDHN DELAELEVRD TGKPIQEASV VDIATGADVI EYFAGLVNGL 

       130        140        150        160        170        180 
GGEQQSLGSN QFFYTRREPL GICAGIGAWN YPIQIAMWKA APALAAGNAM IFKPSEETPL 

       190        200        210        220        230        240 
SALKLAELFT QAGVPDGVFN VVQGDYRVGQ MLTAHPEIDK VSFTGESGTG KKVMADSAAT 

       250        260        270        280        290        300 
LKPVTMELGG KSPLIIFDDA DLDDAVSAAM VANFYTQGEV CTHGTRVYVQ RAMYDAFVEQ 

       310        320        330        340        350        360 
LKERTEKLIV GDPMNMETQI GSLISKSHLE KVLGAISSAK ESGATLLTGG FQVTERGLEK 

       370        380        390        400        410        420 
GCFVAPTVFV DCRDEMPHVQ NEIFGPVMSV LVFDDEDEVI ARANNTQYGL AAGVFTQNLS 

       430        440        450        460        470        480 
KAHRVIHQLQ AGICWINTWG NSPAEMPVGG YKLSGIGREN GQETLLHYTQ TKSVFVELGA 


FDSPYA 

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References

[1]"Complete genome sequence of Vibrio vulnificus CMCP6."
Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E.
Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CMCP6.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016796 Genomic DNA. Translation: AAO08543.1.
RefSeqNP_763553.1. NC_004460.2.

3D structure databases

ProteinModelPortalQ8D3K3.
SMRQ8D3K3. Positions 4-485.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING216895.VV2_1687.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO08543; AAO08543; VV2_1687.
GeneID1181605.
KEGGvvu:VV2_1687.
PATRIC20166716. VBIVibVul94426_4806.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1012.
HOGENOMHOG000271505.
KOK00130.
OMAHIMKQAA.
OrthoDBEOG6BS8QW.
ProtClustDBPRK13252.

Enzyme and pathway databases

BioCycVVUL216895:GIYM-4432-MONOMER.
UniPathwayUPA00529; UER00386.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPMF_00804. BADH.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view]
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. SSF53720. 1 hit.
PROSITEPS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBETB_VIBVU
AccessionPrimary (citable) accession number: Q8D3K3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: March 1, 2003
Last modified: February 19, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways