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Q8D3K3

- BETB_VIBVU

UniProt

Q8D3K3 - BETB_VIBVU

Protein

NAD/NADP-dependent betaine aldehyde dehydrogenase

Gene

betB

Organism
Vibrio vulnificus (strain CMCP6)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    • Comment

    Functioni

    Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid.UniRule annotation

    Catalytic activityi

    Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

    Cofactori

    Binds 2 potassium ions per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi23 – 231Potassium 1UniRule annotation
    Metal bindingi90 – 901Potassium 1UniRule annotation
    Active sitei159 – 1591Charge relay systemUniRule annotation
    Metal bindingi241 – 2411Potassium 2; via carbonyl oxygenUniRule annotation
    Active sitei247 – 2471Proton acceptorUniRule annotation
    Binding sitei281 – 2811NAD/NADPUniRule annotation
    Binding sitei382 – 3821NAD/NADPUniRule annotation
    Metal bindingi452 – 4521Potassium 2; via carbonyl oxygenUniRule annotation
    Metal bindingi455 – 4551Potassium 2; via carbonyl oxygenUniRule annotation
    Active sitei459 – 4591Charge relay systemUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi147 – 1504NAD/NADPUniRule annotation
    Nucleotide bindingi173 – 1764NAD/NADPUniRule annotation
    Nucleotide bindingi225 – 2306NAD/NADPUniRule annotation

    GO - Molecular functioni

    1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Metal-binding, NAD, NADP, Potassium

    Enzyme and pathway databases

    BioCyciVVUL216895:GIYM-4432-MONOMER.
    UniPathwayiUPA00529; UER00386.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD/NADP-dependent betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
    Short name:
    BADHUniRule annotation
    Gene namesi
    Name:betBUniRule annotation
    Ordered Locus Names:VV2_1687
    OrganismiVibrio vulnificus (strain CMCP6)
    Taxonomic identifieri216895 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000002275: Chromosome 2

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 486486NAD/NADP-dependent betaine aldehyde dehydrogenasePRO_0000056556Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei281 – 2811Cysteine sulfenic acid (-SOH)UniRule annotation

    Keywords - PTMi

    Oxidation

    Interactioni

    Subunit structurei

    Dimer of dimers.UniRule annotation

    Protein-protein interaction databases

    STRINGi216895.VV2_1687.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8D3K3.
    SMRiQ8D3K3. Positions 4-485.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1012.
    HOGENOMiHOG000271505.
    KOiK00130.
    OMAiAYWECIS.
    OrthoDBiEOG6BS8QW.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    HAMAPiMF_00804. BADH.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR011264. BADH.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8D3K3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEVTAHYIGG KPFVGDTGES FATLNPATGE VLAHIEQADE RVLGHAIESA    50
    KLGFSVWSSM SAAERSRCLL KAAQLIRDHN DELAELEVRD TGKPIQEASV 100
    VDIATGADVI EYFAGLVNGL GGEQQSLGSN QFFYTRREPL GICAGIGAWN 150
    YPIQIAMWKA APALAAGNAM IFKPSEETPL SALKLAELFT QAGVPDGVFN 200
    VVQGDYRVGQ MLTAHPEIDK VSFTGESGTG KKVMADSAAT LKPVTMELGG 250
    KSPLIIFDDA DLDDAVSAAM VANFYTQGEV CTHGTRVYVQ RAMYDAFVEQ 300
    LKERTEKLIV GDPMNMETQI GSLISKSHLE KVLGAISSAK ESGATLLTGG 350
    FQVTERGLEK GCFVAPTVFV DCRDEMPHVQ NEIFGPVMSV LVFDDEDEVI 400
    ARANNTQYGL AAGVFTQNLS KAHRVIHQLQ AGICWINTWG NSPAEMPVGG 450
    YKLSGIGREN GQETLLHYTQ TKSVFVELGA FDSPYA 486
    Length:486
    Mass (Da):52,281
    Last modified:March 1, 2003 - v1
    Checksum:i26B432CE203BD763
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016796 Genomic DNA. Translation: AAO08543.1.
    RefSeqiNP_763553.1. NC_004460.2.
    WP_011082525.1. NC_004460.2.

    Genome annotation databases

    EnsemblBacteriaiAAO08543; AAO08543; VV2_1687.
    GeneIDi1181605.
    KEGGivvu:VV2_1687.
    PATRICi20166716. VBIVibVul94426_4806.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016796 Genomic DNA. Translation: AAO08543.1 .
    RefSeqi NP_763553.1. NC_004460.2.
    WP_011082525.1. NC_004460.2.

    3D structure databases

    ProteinModelPortali Q8D3K3.
    SMRi Q8D3K3. Positions 4-485.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 216895.VV2_1687.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO08543 ; AAO08543 ; VV2_1687 .
    GeneIDi 1181605.
    KEGGi vvu:VV2_1687.
    PATRICi 20166716. VBIVibVul94426_4806.

    Phylogenomic databases

    eggNOGi COG1012.
    HOGENOMi HOG000271505.
    KOi K00130.
    OMAi AYWECIS.
    OrthoDBi EOG6BS8QW.

    Enzyme and pathway databases

    UniPathwayi UPA00529 ; UER00386 .
    BioCyci VVUL216895:GIYM-4432-MONOMER.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    HAMAPi MF_00804. BADH.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR011264. BADH.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Vibrio vulnificus CMCP6."
      Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E.
      Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CMCP6.

    Entry informationi

    Entry nameiBETB_VIBVU
    AccessioniPrimary (citable) accession number: Q8D3K3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3