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Q8D3K3

- BETB_VIBVU

UniProt

Q8D3K3 - BETB_VIBVU

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Protein

NAD/NADP-dependent betaine aldehyde dehydrogenase

Gene
betB, VV2_1687
Organism
Vibrio vulnificus (strain CMCP6)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid By similarity.UniRule annotation

Catalytic activityi

Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

Binds 2 potassium ions per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi23 – 231Potassium 1 By similarity
Metal bindingi90 – 901Potassium 1 By similarity
Active sitei159 – 1591Charge relay system By similarity
Metal bindingi241 – 2411Potassium 2; via carbonyl oxygen By similarity
Active sitei247 – 2471Proton acceptor By similarity
Binding sitei281 – 2811NAD/NADP By similarity
Binding sitei382 – 3821NAD/NADP By similarity
Metal bindingi452 – 4521Potassium 2; via carbonyl oxygen By similarity
Metal bindingi455 – 4551Potassium 2; via carbonyl oxygen By similarity
Active sitei459 – 4591Charge relay system By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi147 – 1504NAD/NADP By similarity
Nucleotide bindingi173 – 1764NAD/NADP By similarity
Nucleotide bindingi225 – 2306NAD/NADP By similarity

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, NADP, Potassium

Enzyme and pathway databases

BioCyciVVUL216895:GIYM-4432-MONOMER.
UniPathwayiUPA00529; UER00386.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD/NADP-dependent betaine aldehyde dehydrogenase (EC:1.2.1.8)
Short name:
BADH
Gene namesi
Name:betB
Ordered Locus Names:VV2_1687
OrganismiVibrio vulnificus (strain CMCP6)
Taxonomic identifieri216895 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000002275: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 486486NAD/NADP-dependent betaine aldehyde dehydrogenaseUniRule annotationPRO_0000056556Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei281 – 2811Cysteine sulfenic acid (-SOH) By similarity

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Dimer of dimers By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi216895.VV2_1687.

Structurei

3D structure databases

ProteinModelPortaliQ8D3K3.
SMRiQ8D3K3. Positions 4-485.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
KOiK00130.
OMAiAYWECIS.
OrthoDBiEOG6BS8QW.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPiMF_00804. BADH.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8D3K3-1 [UniParc]FASTAAdd to Basket

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MEVTAHYIGG KPFVGDTGES FATLNPATGE VLAHIEQADE RVLGHAIESA    50
KLGFSVWSSM SAAERSRCLL KAAQLIRDHN DELAELEVRD TGKPIQEASV 100
VDIATGADVI EYFAGLVNGL GGEQQSLGSN QFFYTRREPL GICAGIGAWN 150
YPIQIAMWKA APALAAGNAM IFKPSEETPL SALKLAELFT QAGVPDGVFN 200
VVQGDYRVGQ MLTAHPEIDK VSFTGESGTG KKVMADSAAT LKPVTMELGG 250
KSPLIIFDDA DLDDAVSAAM VANFYTQGEV CTHGTRVYVQ RAMYDAFVEQ 300
LKERTEKLIV GDPMNMETQI GSLISKSHLE KVLGAISSAK ESGATLLTGG 350
FQVTERGLEK GCFVAPTVFV DCRDEMPHVQ NEIFGPVMSV LVFDDEDEVI 400
ARANNTQYGL AAGVFTQNLS KAHRVIHQLQ AGICWINTWG NSPAEMPVGG 450
YKLSGIGREN GQETLLHYTQ TKSVFVELGA FDSPYA 486
Length:486
Mass (Da):52,281
Last modified:March 1, 2003 - v1
Checksum:i26B432CE203BD763
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016796 Genomic DNA. Translation: AAO08543.1.
RefSeqiNP_763553.1. NC_004460.2.
WP_011082525.1. NC_004460.2.

Genome annotation databases

EnsemblBacteriaiAAO08543; AAO08543; VV2_1687.
GeneIDi1181605.
KEGGivvu:VV2_1687.
PATRICi20166716. VBIVibVul94426_4806.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016796 Genomic DNA. Translation: AAO08543.1 .
RefSeqi NP_763553.1. NC_004460.2.
WP_011082525.1. NC_004460.2.

3D structure databases

ProteinModelPortali Q8D3K3.
SMRi Q8D3K3. Positions 4-485.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 216895.VV2_1687.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO08543 ; AAO08543 ; VV2_1687 .
GeneIDi 1181605.
KEGGi vvu:VV2_1687.
PATRICi 20166716. VBIVibVul94426_4806.

Phylogenomic databases

eggNOGi COG1012.
HOGENOMi HOG000271505.
KOi K00130.
OMAi AYWECIS.
OrthoDBi EOG6BS8QW.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00386 .
BioCyci VVUL216895:GIYM-4432-MONOMER.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPi MF_00804. BADH.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
PROSITEi PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Vibrio vulnificus CMCP6."
    Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E.
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CMCP6.

Entry informationi

Entry nameiBETB_VIBVU
AccessioniPrimary (citable) accession number: Q8D3K3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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