ID   BETA_VIBVU              Reviewed;         560 AA.
AC   Q8D3K2;
DT   16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   16-JUN-2009, entry version 38.
DE   RecName: Full=Choline dehydrogenase;
DE            Short=CHD;
DE            Short=CDH;
DE            EC=1.1.99.1;
GN   Name=betA; OrderedLocusNames=VV2_1688;
OS   Vibrio vulnificus.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales;
OC   Vibrionaceae; Vibrio.
OX   NCBI_TaxID=672;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CMCP6;
RA   Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H.,
RA   Choy H.E.;
RT   "Complete genome sequence of Vibrio vulnificus CMCP6.";
RL   Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Can catalyze the oxidation of choline to betaine
CC       aldehyde and betaine aldehyde to glycine betaine (By similarity).
CC   -!- CATALYTIC ACTIVITY: Choline + acceptor = betaine aldehyde +
CC       reduced acceptor.
CC   -!- COFACTOR: FAD (By similarity).
CC   -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis
CC       via choline pathway; betaine aldehyde from choline (cytochrome c
CC       reductase route): step 1/1.
CC   -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
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DR   EMBL; AE016796; AAO08544.1; -; Genomic_DNA.
DR   RefSeq; NP_763554.1; -.
DR   GeneID; 1181606; -.
DR   GenomeReviews; AE016796_GR; VV2_1688.
DR   KEGG; vvu:VV2_1688; -.
DR   HOGENOM; Q8D3K2; -.
DR   OMA; Q8D3K2; HMTVKNG.
DR   BioCyc; VVUL216895:VV2_1688-MON; -.
DR   BRENDA; 1.1.99.1; 277169.
DR   GO; GO:0008812; F:choline dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0050660; F:FAD binding; IEA:InterPro.
DR   GO; GO:0006066; P:cellular alcohol metabolic process; IEA:InterPro.
DR   GO; GO:0019285; P:glycine betaine biosynthetic process from c...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00750; -; 1.
DR   InterPro; IPR011533; Choline_dehydrogenase.
DR   InterPro; IPR012132; GMC_OxRdtase.
DR   InterPro; IPR000172; GMC_OxRdtase_N.
DR   InterPro; IPR007867; GMC_OxRtase_C.
DR   Pfam; PF05199; GMC_oxred_C; 1.
DR   Pfam; PF00732; GMC_oxred_N; 1.
DR   PIRSF; PIRSF000137; Alcohol_oxidase; 1.
DR   TIGRFAMs; TIGR01810; betA; 1.
DR   PROSITE; PS00623; GMC_OXRED_1; 1.
DR   PROSITE; PS00624; GMC_OXRED_2; FALSE_NEG.
PE   3: Inferred from homology;
KW   Complete proteome; FAD; Flavoprotein; Oxidoreductase.
FT   CHAIN         1    560       Choline dehydrogenase.
FT                                /FTId=PRO_0000205606.
FT   NP_BIND       6     35       FAD (Probable).
FT   ACT_SITE    470    470       By similarity.
SQ   SEQUENCE   560 AA;  62277 MW;  CD7AA79E8B358748 CRC64;
     MQQHYDYIIV GAGSAGCVLA DRLSESGDHS VLLLEAGGSD KSIFIQMPTA LSYPMNSEKY
     AWQFETDAEA DLDGRRLHCP RGKVLGGSSS INGMVYVRGH ACDFDEWEEQ GAKGWNYQAC
     LPYFRRAENW IDGEDEYRGG DGPLSTCAGN KMTLNPLYRA FIDAGKEAGY PETSDYNGYQ
     QEGFGPMHMT VKNGVRASTS NAYLSRAKKR SNFKLIKGVV VQRILLEEKR AVGVEFELAG
     ELRTCFAKNE VISSAGSIGS VQLLQLSGIG PKTVLEKAGV TPVHHLPGVG QNLQDHLEVY
     FQYHCQKPIT LNGKLDWFSK GLIGAEWILT RKGLGATNHF ESCAFIRSRA GLKWPNIQYH
     FLPAAMRYDG QAAFDGHGFQ VHVGPNKPES RGRVEIVSAN PSDKPKIQFN YLSTERDRQD
     WRDCIRLTRE ILAQPAMDEF RGEEIQPGIN VATDAEIDQW VKENVESAYH PSCSCKMGAD
     DDPMAVLDEE CRVRGITNLR VVDSSVFPTI PNGNLNAPTI MVAERAADLI LHKQPLPPQR
     SKVWLAPSWE TQQRTGEPMR
//