Reviewed, UniProtKB/Swiss-Prot Q8D3K2 (BETA_VIBVU)

Names and origin

Protein names

Recommended name:
    Choline dehydrogenase
      Short name=CHD
      Short name=CDH
    EC=1.1.99.1

Gene names

Name:	betA
Ordered Locus Names:	VV2_1688

Organism

Vibrio vulnificus [Complete proteome] [HAMAP]

Taxonomic identifier

672 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length	560 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine By similarity.
Catalytic activity	Choline + acceptor = betaine aldehyde + reduced acceptor. HAMAP MF_00750
Cofactor	FAD By similarity.
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. HAMAP MF_00750
Sequence similarities	Belongs to the GMC oxidoreductase family.

Ontologies

Keywords
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular alcohol metabolic process Inferred from electronic annotation. Source: InterPro glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro choline dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 560	560	Choline dehydrogenase HAMAP MF_00750		PRO_0000205606
Regions
	Nucleotide binding	6 – 35	30	FAD Probable
Sites
	Active site	470	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8D3K2-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: CD7AA79E8B358748	FASTA	560	62,277
	10 20 30 40 50 60 MQQHYDYIIV GAGSAGCVLA DRLSESGDHS VLLLEAGGSD KSIFIQMPTA LSYPMNSEKY 70 80 90 100 110 120 AWQFETDAEA DLDGRRLHCP RGKVLGGSSS INGMVYVRGH ACDFDEWEEQ GAKGWNYQAC 130 140 150 160 170 180 LPYFRRAENW IDGEDEYRGG DGPLSTCAGN KMTLNPLYRA FIDAGKEAGY PETSDYNGYQ 190 200 210 220 230 240 QEGFGPMHMT VKNGVRASTS NAYLSRAKKR SNFKLIKGVV VQRILLEEKR AVGVEFELAG 250 260 270 280 290 300 ELRTCFAKNE VISSAGSIGS VQLLQLSGIG PKTVLEKAGV TPVHHLPGVG QNLQDHLEVY 310 320 330 340 350 360 FQYHCQKPIT LNGKLDWFSK GLIGAEWILT RKGLGATNHF ESCAFIRSRA GLKWPNIQYH 370 380 390 400 410 420 FLPAAMRYDG QAAFDGHGFQ VHVGPNKPES RGRVEIVSAN PSDKPKIQFN YLSTERDRQD 430 440 450 460 470 480 WRDCIRLTRE ILAQPAMDEF RGEEIQPGIN VATDAEIDQW VKENVESAYH PSCSCKMGAD 490 500 510 520 530 540 DDPMAVLDEE CRVRGITNLR VVDSSVFPTI PNGNLNAPTI MVAERAADLI LHKQPLPPQR 550 560 SKVWLAPSWE TQQRTGEPMR

References

[1]	"Complete genome sequence of Vibrio vulnificus CMCP6." Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E. Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CMCP6.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE016796 Genomic DNA. Translation: AAO08544.1.
RefSeq	NP_763554.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1181606.
GenomeReviews	Gene locus VV2_1688 in contig AE016796_GR.
KEGG	vvu:VV2_1688.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8D3K2.
OMA	Q8D3K2. HMTVKNG.
Enzyme and pathway databases
BioCyc	VVUL216895:VV2_1688-MON.
BRENDA	1.1.99.1. 277169.
Family and domain databases
HAMAP	MF_00750. [Tree]
InterPro	IPR011533. Choline_dehydrogenase. IPR012132. GMC_OxRdtase. IPR000172. GMC_OxRdtase_N. IPR007867. GMC_OxRtase_C. [Graphical view]
Pfam	PF05199. GMC_oxred_C. 1 hit. PF00732. GMC_oxred_N. 1 hit. [Graphical view]
PIRSF	PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMs	TIGR01810. betA. 1 hit.
PROSITE	PS00623. GMC_OXRED_1. 1 hit. PS00624. GMC_OXRED_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BETA_VIBVU

Accession

Primary (citable) accession number: Q8D3K2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 16, 2004
Last sequence update:	March 1, 2003
Last modified:	June 16, 2009
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)