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Q8D3K2

- BETA_VIBVU

UniProt

Q8D3K2 - BETA_VIBVU

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Protein

Oxygen-dependent choline dehydrogenase

Gene
betA, VV2_1688
Organism
Vibrio vulnificus (strain CMCP6)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate By similarity.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FAD By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei470 – 4701 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi6 – 3530FAD By similarityAdd
BLAST

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
  2. choline dehydrogenase activity Source: UniProtKB-HAMAP
  3. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciVVUL216895:GIYM-4433-MONOMER.
UniPathwayiUPA00529; UER00385.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenase (EC:1.1.99.1)
Short name:
CDH
Short name:
CHD
Alternative name(s):
Betaine aldehyde dehydrogenase (EC:1.2.1.8)
Short name:
BADH
Gene namesi
Name:betA
Ordered Locus Names:VV2_1688
OrganismiVibrio vulnificus (strain CMCP6)
Taxonomic identifieri216895 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000002275: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 560560Oxygen-dependent choline dehydrogenaseUniRule annotationPRO_0000205606Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi216895.VV2_1688.

Structurei

3D structure databases

ProteinModelPortaliQ8D3K2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2303.
HOGENOMiHOG000139600.
KOiK00108.
OMAiREMHCPR.
OrthoDBiEOG67HJQP.

Family and domain databases

HAMAPiMF_00750. Choline_dehydrogen.
InterProiIPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8D3K2-1 [UniParc]FASTAAdd to Basket

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MQQHYDYIIV GAGSAGCVLA DRLSESGDHS VLLLEAGGSD KSIFIQMPTA    50
LSYPMNSEKY AWQFETDAEA DLDGRRLHCP RGKVLGGSSS INGMVYVRGH 100
ACDFDEWEEQ GAKGWNYQAC LPYFRRAENW IDGEDEYRGG DGPLSTCAGN 150
KMTLNPLYRA FIDAGKEAGY PETSDYNGYQ QEGFGPMHMT VKNGVRASTS 200
NAYLSRAKKR SNFKLIKGVV VQRILLEEKR AVGVEFELAG ELRTCFAKNE 250
VISSAGSIGS VQLLQLSGIG PKTVLEKAGV TPVHHLPGVG QNLQDHLEVY 300
FQYHCQKPIT LNGKLDWFSK GLIGAEWILT RKGLGATNHF ESCAFIRSRA 350
GLKWPNIQYH FLPAAMRYDG QAAFDGHGFQ VHVGPNKPES RGRVEIVSAN 400
PSDKPKIQFN YLSTERDRQD WRDCIRLTRE ILAQPAMDEF RGEEIQPGIN 450
VATDAEIDQW VKENVESAYH PSCSCKMGAD DDPMAVLDEE CRVRGITNLR 500
VVDSSVFPTI PNGNLNAPTI MVAERAADLI LHKQPLPPQR SKVWLAPSWE 550
TQQRTGEPMR 560
Length:560
Mass (Da):62,277
Last modified:March 1, 2003 - v1
Checksum:iCD7AA79E8B358748
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016796 Genomic DNA. Translation: AAO08544.1.
RefSeqiNP_763554.1. NC_004460.2.

Genome annotation databases

EnsemblBacteriaiAAO08544; AAO08544; VV2_1688.
GeneIDi1181606.
KEGGivvu:VV2_1688.
PATRICi20166718. VBIVibVul94426_4807.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016796 Genomic DNA. Translation: AAO08544.1 .
RefSeqi NP_763554.1. NC_004460.2.

3D structure databases

ProteinModelPortali Q8D3K2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 216895.VV2_1688.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO08544 ; AAO08544 ; VV2_1688 .
GeneIDi 1181606.
KEGGi vvu:VV2_1688.
PATRICi 20166718. VBIVibVul94426_4807.

Phylogenomic databases

eggNOGi COG2303.
HOGENOMi HOG000139600.
KOi K00108.
OMAi REMHCPR.
OrthoDBi EOG67HJQP.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00385 .
BioCyci VVUL216895:GIYM-4433-MONOMER.

Family and domain databases

HAMAPi MF_00750. Choline_dehydrogen.
InterProi IPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view ]
Pfami PF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsi TIGR01810. betA. 1 hit.
PROSITEi PS00623. GMC_OXRED_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Vibrio vulnificus CMCP6."
    Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E.
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CMCP6.

Entry informationi

Entry nameiBETA_VIBVU
AccessioniPrimary (citable) accession number: Q8D3K2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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