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Q8D3J0

- GLMS_WIGBR

UniProt

Q8D3J0 - GLMS_WIGBR

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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene
glmS, WIGBR0110
Organism
Wigglesworthia glossinidia brevipalpis
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source By similarity.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activity By similarity
Active sitei607 – 6071For Fru-6P isomerization activity By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene namesi
Name:glmS
Ordered Locus Names:WIGBR0110
OrganismiWigglesworthia glossinidia brevipalpis
Taxonomic identifieri36870 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeWigglesworthia
ProteomesiUP000000562: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 612611Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotationPRO_0000135413Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi36870.WGLp011.

Structurei

3D structure databases

ProteinModelPortaliQ8D3J0.
SMRiQ8D3J0. Positions 2-612.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 221220Glutamine amidotransferase type-2Add
BLAST
Domaini289 – 429141SIS 1Add
BLAST
Domaini461 – 602142SIS 2Add
BLAST

Sequence similaritiesi

Contains 2 SIS domains.

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
KOiK00820.
OMAiPVTRRFM.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8D3J0-1 [UniParc]FASTAAdd to Basket

« Hide

MCGIVGIVSQ RNILKFLLTG LNHLEYRGYD SSGLAVIDNN NKLRCIKKVG    50
KVNVLEKAIL NKKMSFLGKT GVAHTRWATH GPPTENNAHP HISGNIAVVH 100
NGIIENHEHL RSKLKSYKYK FNSDTDTEVI AHLIHWEQNK NGGSLTEVVK 150
RVSRMLFGIY STVVMDSNNP NILIAECFGS PLIIGLGICE NSIASDQLAL 200
LNLSKNFIFL KNGDIAEITN SKIRIWDKFN NKINRDTVQT KISLDINKKG 250
NFKHFLKKEI FEQPKAIKNT LKNRIKKNYI YLSELSGKFN KTIKYIKHIK 300
LVACGSSYNS AMVSKYWFEK FAGLSCNIEI ASEFCYRKIV ICKNSLLIFL 350
SQSGETADIL SALRLIKKFN YVFSISICNT PESSLIRESE ISILTHAGVE 400
ISVASTKTFT TQLTALLMLI SHICYIRKIN EKSQTDIFNA IQILPNRIEQ 450
MLLVKNSVKK LVKNFSNKKN VIIIGRGELY PIAIEAALKL KETSYIHAEG 500
YAAGELKHGT LALIDTNTPV IVLVCKNKLL RKTLSNIEEI KSRGGQIYIF 550
SEKSIFFSKS SNVNITKLPF VEELLVPMAY IVPMQLLSYY IGIEKNVDVD 600
HPRNLAKTVT VE 612
Length:612
Mass (Da):68,922
Last modified:January 23, 2007 - v3
Checksum:i7EEFEF0DFA38FC9B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000021 Genomic DNA. Translation: BAC24157.1.
RefSeqiNP_871014.1. NC_004344.2.

Genome annotation databases

EnsemblBacteriaiBAC24157; BAC24157; BAC24157.
GeneIDi1257467.
KEGGiwbr:WGLp011.
PATRICi24024131. VBIWigGlo15804_0018.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000021 Genomic DNA. Translation: BAC24157.1 .
RefSeqi NP_871014.1. NC_004344.2.

3D structure databases

ProteinModelPortali Q8D3J0.
SMRi Q8D3J0. Positions 2-612.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 36870.WGLp011.

Protein family/group databases

MEROPSi C44.971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC24157 ; BAC24157 ; BAC24157 .
GeneIDi 1257467.
KEGGi wbr:WGLp011.
PATRICi 24024131. VBIWigGlo15804_0018.

Phylogenomic databases

eggNOGi COG0449.
KOi K00820.
OMAi PVTRRFM.
OrthoDBi EOG6KT2Q1.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the endocellular obligate symbiont of tsetse flies, Wigglesworthia glossinidia."
    Akman L., Yamashita A., Watanabe H., Oshima K., Shiba T., Hattori M., Aksoy S.
    Nat. Genet. 32:402-407(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiGLMS_WIGBR
AccessioniPrimary (citable) accession number: Q8D3J0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2003
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 67 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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