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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Wigglesworthia glossinidia brevipalpis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Nucleophile; for GATase activityUniRule annotation1
Active sitei607For Fru-6P isomerization activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:WIGBR0110
OrganismiWigglesworthia glossinidia brevipalpis
Taxonomic identifieri36870 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeWigglesworthia
Proteomesi
  • UP000000562 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation
ChainiPRO_00001354132 – 612Glutamine--fructose-6-phosphate aminotransferase [isomerizing]Add BLAST611

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi36870.WGLp011.

Structurei

3D structure databases

ProteinModelPortaliQ8D3J0.
SMRiQ8D3J0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 221Glutamine amidotransferase type-2UniRule annotationAdd BLAST220
Domaini289 – 429SIS 1UniRule annotationAdd BLAST141
Domaini461 – 602SIS 2UniRule annotationAdd BLAST142

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiENOG4105C46. Bacteria.
COG0449. LUCA.
KOiK00820.
OMAiASEYRYA.
OrthoDBiPOG091H0061.

Family and domain databases

CDDicd05008. SIS_GlmS_GlmD_1. 1 hit.
cd05009. SIS_GlmS_GlmD_2. 1 hit.
Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS. 1 hit.
InterProiView protein in InterPro
IPR017932. GATase_2_dom.
IPR035466. GlmS/AgaS_SIS.
IPR035490. GlmS/FrlB_SIS.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiView protein in Pfam
PF01380. SIS. 2 hits.
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiView protein in PROSITE
PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8D3J0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGIVGIVSQ RNILKFLLTG LNHLEYRGYD SSGLAVIDNN NKLRCIKKVG
60 70 80 90 100
KVNVLEKAIL NKKMSFLGKT GVAHTRWATH GPPTENNAHP HISGNIAVVH
110 120 130 140 150
NGIIENHEHL RSKLKSYKYK FNSDTDTEVI AHLIHWEQNK NGGSLTEVVK
160 170 180 190 200
RVSRMLFGIY STVVMDSNNP NILIAECFGS PLIIGLGICE NSIASDQLAL
210 220 230 240 250
LNLSKNFIFL KNGDIAEITN SKIRIWDKFN NKINRDTVQT KISLDINKKG
260 270 280 290 300
NFKHFLKKEI FEQPKAIKNT LKNRIKKNYI YLSELSGKFN KTIKYIKHIK
310 320 330 340 350
LVACGSSYNS AMVSKYWFEK FAGLSCNIEI ASEFCYRKIV ICKNSLLIFL
360 370 380 390 400
SQSGETADIL SALRLIKKFN YVFSISICNT PESSLIRESE ISILTHAGVE
410 420 430 440 450
ISVASTKTFT TQLTALLMLI SHICYIRKIN EKSQTDIFNA IQILPNRIEQ
460 470 480 490 500
MLLVKNSVKK LVKNFSNKKN VIIIGRGELY PIAIEAALKL KETSYIHAEG
510 520 530 540 550
YAAGELKHGT LALIDTNTPV IVLVCKNKLL RKTLSNIEEI KSRGGQIYIF
560 570 580 590 600
SEKSIFFSKS SNVNITKLPF VEELLVPMAY IVPMQLLSYY IGIEKNVDVD
610
HPRNLAKTVT VE
Length:612
Mass (Da):68,922
Last modified:January 23, 2007 - v3
Checksum:i7EEFEF0DFA38FC9B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000021 Genomic DNA. Translation: BAC24157.1.
RefSeqiWP_011069815.1. NC_004344.2.

Genome annotation databases

EnsemblBacteriaiBAC24157; BAC24157; BAC24157.
KEGGiwbr:glmS.

Similar proteinsi

Entry informationi

Entry nameiGLMS_WIGBR
AccessioniPrimary (citable) accession number: Q8D3J0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2003
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 85 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome