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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Wigglesworthia glossinidia brevipalpis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
Active sitei607 – 6071For Fru-6P isomerization activityUniRule annotation

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:WIGBR0110
OrganismiWigglesworthia glossinidia brevipalpis
Taxonomic identifieri36870 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeWigglesworthia
ProteomesiUP000000562 Componenti: Chromosome

Subcellular locationi

  1. Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedUniRule annotation
Chaini2 – 612611Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135413Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi36870.WGLp011.

Structurei

3D structure databases

ProteinModelPortaliQ8D3J0.
SMRiQ8D3J0. Positions 2-612.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 221220Glutamine amidotransferase type-2UniRule annotationAdd
BLAST
Domaini289 – 429141SIS 1UniRule annotationAdd
BLAST
Domaini461 – 602142SIS 2UniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
Contains 2 SIS domains.UniRule annotation

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
KOiK00820.
OMAiSEFRYAP.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8D3J0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGIVGIVSQ RNILKFLLTG LNHLEYRGYD SSGLAVIDNN NKLRCIKKVG
60 70 80 90 100
KVNVLEKAIL NKKMSFLGKT GVAHTRWATH GPPTENNAHP HISGNIAVVH
110 120 130 140 150
NGIIENHEHL RSKLKSYKYK FNSDTDTEVI AHLIHWEQNK NGGSLTEVVK
160 170 180 190 200
RVSRMLFGIY STVVMDSNNP NILIAECFGS PLIIGLGICE NSIASDQLAL
210 220 230 240 250
LNLSKNFIFL KNGDIAEITN SKIRIWDKFN NKINRDTVQT KISLDINKKG
260 270 280 290 300
NFKHFLKKEI FEQPKAIKNT LKNRIKKNYI YLSELSGKFN KTIKYIKHIK
310 320 330 340 350
LVACGSSYNS AMVSKYWFEK FAGLSCNIEI ASEFCYRKIV ICKNSLLIFL
360 370 380 390 400
SQSGETADIL SALRLIKKFN YVFSISICNT PESSLIRESE ISILTHAGVE
410 420 430 440 450
ISVASTKTFT TQLTALLMLI SHICYIRKIN EKSQTDIFNA IQILPNRIEQ
460 470 480 490 500
MLLVKNSVKK LVKNFSNKKN VIIIGRGELY PIAIEAALKL KETSYIHAEG
510 520 530 540 550
YAAGELKHGT LALIDTNTPV IVLVCKNKLL RKTLSNIEEI KSRGGQIYIF
560 570 580 590 600
SEKSIFFSKS SNVNITKLPF VEELLVPMAY IVPMQLLSYY IGIEKNVDVD
610
HPRNLAKTVT VE
Length:612
Mass (Da):68,922
Last modified:January 23, 2007 - v3
Checksum:i7EEFEF0DFA38FC9B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000021 Genomic DNA. Translation: BAC24157.1.
RefSeqiNP_871014.1. NC_004344.2.

Genome annotation databases

EnsemblBacteriaiBAC24157; BAC24157; BAC24157.
KEGGiwbr:WGLp011.
PATRICi24024131. VBIWigGlo15804_0018.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000021 Genomic DNA. Translation: BAC24157.1.
RefSeqiNP_871014.1. NC_004344.2.

3D structure databases

ProteinModelPortaliQ8D3J0.
SMRiQ8D3J0. Positions 2-612.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi36870.WGLp011.

Protein family/group databases

MEROPSiC44.971.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC24157; BAC24157; BAC24157.
KEGGiwbr:WGLp011.
PATRICi24024131. VBIWigGlo15804_0018.

Phylogenomic databases

eggNOGiCOG0449.
KOiK00820.
OMAiSEFRYAP.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the endocellular obligate symbiont of tsetse flies, Wigglesworthia glossinidia."
    Akman L., Yamashita A., Watanabe H., Oshima K., Shiba T., Hattori M., Aksoy S.
    Nat. Genet. 32:402-407(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiGLMS_WIGBR
AccessioniPrimary (citable) accession number: Q8D3J0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2003
Last sequence update: January 23, 2007
Last modified: April 1, 2015
This is version 71 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.