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Q8D391

- NADK_WIGBR

UniProt

Q8D391 - NADK_WIGBR

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Protein

NAD kinase

Gene

nadK

Organism
Wigglesworthia glossinidia brevipalpis
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei73 – 731Proton acceptorUniRule annotation
Binding sitei78 – 781NADUniRule annotation
Binding sitei157 – 1571NADUniRule annotation
Binding sitei174 – 1741NADUniRule annotation
Binding sitei176 – 1761NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi73 – 742NADUniRule annotation
Nucleotide bindingi146 – 1472NADUniRule annotation
Nucleotide bindingi187 – 1926NADUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:WIGBR1100
OrganismiWigglesworthia glossinidia brevipalpis
Taxonomic identifieri36870 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeWigglesworthia
ProteomesiUP000000562: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 295295NAD kinasePRO_0000120690Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi36870.WGLp110.

Structurei

3D structure databases

ProteinModelPortaliQ8D391.
SMRiQ8D391. Positions 5-291.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061.
KOiK00858.
OMAiTHEMLYH.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8D391-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNYVFCIIGI IGYRLCLEQL SIYNNLYNWL IKKGYSVILE NNIAQALNLN
60 70 80 90 100
NVISGSTFDI GEKADLAIII GGDGSMLRIA KILSNYPIKV IGINTGNLGF
110 120 130 140 150
LTDLNPKSAL STLNYILNGN FYEEKRFLLN VITIKNNIKS KKHILNEVVV
160 170 180 190 200
HSNNVAKMIE FKVYIDDVFS FFQRADGLII STPTGSTAYS LSAGGPILMP
210 220 230 240 250
LLNAIIIIPM FPHGLYSRPL VISAKSKIKI KFSKKILNLS ISCDGTSPFK
260 270 280 290
VYRNNEIVIK KSKKFLKLIH SNNYNYFNVL RKKLGWSKKF FKKIK
Length:295
Mass (Da):33,258
Last modified:March 1, 2003 - v1
Checksum:i301A6C2D58C02DB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000021 Genomic DNA. Translation: BAC24256.1.
RefSeqiNP_871113.1. NC_004344.2.

Genome annotation databases

EnsemblBacteriaiBAC24256; BAC24256; BAC24256.
GeneIDi1257544.
KEGGiwbr:WGLp110.
PATRICi24024347. VBIWigGlo15804_0126.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000021 Genomic DNA. Translation: BAC24256.1 .
RefSeqi NP_871113.1. NC_004344.2.

3D structure databases

ProteinModelPortali Q8D391.
SMRi Q8D391. Positions 5-291.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 36870.WGLp110.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC24256 ; BAC24256 ; BAC24256 .
GeneIDi 1257544.
KEGGi wbr:WGLp110.
PATRICi 24024347. VBIWigGlo15804_0126.

Phylogenomic databases

eggNOGi COG0061.
KOi K00858.
OMAi THEMLYH.
OrthoDBi EOG6PZXDR.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the endocellular obligate symbiont of tsetse flies, Wigglesworthia glossinidia."
    Akman L., Yamashita A., Watanabe H., Oshima K., Shiba T., Hattori M., Aksoy S.
    Nat. Genet. 32:402-407(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiNADK_WIGBR
AccessioniPrimary (citable) accession number: Q8D391
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2003
Last sequence update: March 1, 2003
Last modified: November 26, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3