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Q8D372 (SYR_WIGBR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:WIGBR1290
OrganismWigglesworthia glossinidia brevipalpis [Complete proteome] [HAMAP]
Taxonomic identifier36870 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeWigglesworthia

Protein attributes

Sequence length576 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 576576Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_0000151636

Regions

Motif123 – 13311"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
Q8D372 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 71AD4F8A8E87C8CA

FASTA57667,095
        10         20         30         40         50         60 
MNIKNILLKN VKNALKPSNL DLRNLKIKKT KFKKFGNYQI DGIFSILNKN KINLNELLNK 

        70         80         90        100        110        120 
ILPIINMKLI NVSEKIEFVK PGYINIFLKK SWIEDNLLKI YHSNKLGISK LKKKTIIIDY 

       130        140        150        160        170        180 
SSPNIGKEMH VGHMRSTIIG DSISLILELL GHKVIRANHI GDWGNQFGML LAYFNEKQNL 

       190        200        210        220        230        240 
KFSEITCTDL ENYYINAKKK YDKDLEFKKK SQFFTLKLQK KEKDCINIWK KITNLSIENN 

       250        260        270        280        290        300 
QKIYDQLNIK LNKTHIMGES LYNDFVPYII SDLPKKNLAI NKSGNIMVIL NNFKNKQGKS 

       310        320        330        340        350        360 
MGVILKKRNG TYLYSVIDIA CIKYRYDFFK AQKIIYYTDS RQSQHLLQVF DIVRKAKYIP 

       370        380        390        400        410        420 
NFVKLEHHKF GMVLKKDKTP FKTRSGDTIK LSDLLKKSKE KAKKLIIKKN PNTSIDEIES 

       430        440        450        460        470        480 
LSQAIGIGSI KYFELSKNRE TDYIFNWDNI LSFNGNTAPY IQYAYTRVIS LIKKNKLKNK 

       490        500        510        520        530        540 
NNVKFLLKKE EEIDLSICLL QFEEIINDVS KLGTPHILCN YLYDLSKTFS VFYENCSIIK 

       550        560        570 
TKEESVKNSR LFLSILTSRT LKVGLELLGI PMVEKM 

« Hide

References

[1]"Genome sequence of the endocellular obligate symbiont of tsetse flies, Wigglesworthia glossinidia."
Akman L., Yamashita A., Watanabe H., Oshima K., Shiba T., Hattori M., Aksoy S.
Nat. Genet. 32:402-407(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000021 Genomic DNA. Translation: BAC24275.1.
RefSeqNP_871132.1. NC_004344.2.

3D structure databases

ProteinModelPortalQ8D372.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING36870.WGLp129.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC24275; BAC24275; BAC24275.
GeneID1256923.
KEGGwbr:WGLp129.
PATRIC24024407. VBIWigGlo15804_0147.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0018.
KOK01887.
OMAYVKFHDE.
OrthoDBEOG6JB13C.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_WIGBR
AccessionPrimary (citable) accession number: Q8D372
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2003
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries